Seen it long ago, but everyone was at Simpsons house, Krusty pulls out a crack pipe and smoked something. Forget exacly what it was though lol.
when sideshow bob ran for mayor at the beginning there is a rush limbaugh-esque radio guy who says that Joe Quimby is a "wife-swapping, pot-smoking illiterate" while Joe is watering a weed plant in his closet, to which he replies "I am, eh, no longer illiterate." Homer gets addicted to painkillers in "behind the laughter".
Man i cant believe noone mentioned the one were he gets trapped on a island and licks a frog and trips
the episode where the simpsons get their kids taken away, Marge tests positive for crack and PCP (I think). When she gets a clear retest, she says "the only thing I'm high on is love. Love for my son and daughters. Yes, a little LSD is all I need."