i probably don't pay enough attention, but i haven't had many adverse side-effects. admittedly, your sex drive does become slightly diminished. i have had bad depression & anxiety for years, but i don't think that is related to the pill. if it was more feesable, i would be off the pill tomorrow. i really don't like messing with my body. thing is it keeps my skin & periods in check...without i have bad break outs and totally unmanagable periods. as everyone has said, it's a matter of finding one that suits you. i took monofeme for 6 months and turned quite sour! i was on edge, i fell apart at the drop of a hat, i was a mad, screaming bitch.