It plays a part in the particulars of our experience and it is absolutely essential that we act in self interest. Self interest becomes a beneficial dynamic when we see that our fundamental needs and interests are one in the same.
The ego as you describe it, affects nothing other than our ability to appreciate. It does not change the shape of reality. We are spirit reaching toward spirit in all things. In it's simplest form, spirit is breath. Consider we take a breath and our first desire is to have another.