Cross tolerance

I cant parachute, like its almost impossible for me to swollow that type of paper its a horrible gag reflex, yet i can snort like a champ. But i will try it next time its not the first time ive been told that

 

EAT it

 

Parachute along with a drink to wash it down with!


And right, I'm gonna hi-jack this thread a bit..

Been trying to educate myself on why the tolerance between LSD and MDMA, and other such combinations. I'm certainly no neuroscientist, so I've just pieced together my interpretation of a shit ton of different web-sources..

In nice basic terms, I've gathered that MDMA is an agonist of the 5-HT receptors. Through various dark arts and black magic, this then stimulates the rate that serotonin is released in to your synapses and consequently your serotonin receptors go apeshit and you feel really really good.. but most of your serotonin is gone by the time you're done - cue the "comedown"(right?).
LSD is also an agonist of the 5-HT's, but only a few of them and doesn't actually release serotonin - it just mimics it.

That's where I get confused, since LSD doesn't actually deplete your serotonin - why do you get a tolerance? I've seen shit saying that it acts as an antagonist as well as an agonist which would make sense since it's blocking the agonist reaction.. but how the fuck can it be both? Does it "agonise" and then just chill in that receptor for a few days?

Or have I completely mis-interpreted things..

 

For no other reason that I'm aware of except that some things taste like crap in a drink.

 

meatymushroom, i'm not so sure of LSD's mechanism of action (whether it releases serotonin, or maybe prevents re-uptake of serotonin which has basically the same effect, or like you said, it might just mimic serotonin in the receptor site.

but i'm thinking a normal dose of LSD, even though it's sub milligram levels, is a higher concentration than endogenous (naturally in the body) serotonin. so your receptors get "flooded" and because of this over stimulation, some of the receptors are internalized. when you flood your brain with serotonin or a serotonin mimicking drug, your brain deals with this by getting rid of some of the spots for serotonin to bind to. say you usually have 100 receptors, of which 10 are normally bound by serotonin at a given time. now with an LSD dose, now 60 more are bound by LSD (or with MDMA, 70 of them are bound with serotonin that the mdma released). after awhile your neurons start taking in the receptors so that maybe there are only 65 left on the surface of the neuron cell. now it doesn't matter if there are 100 molecules of serotonin or LSD in the synapse, because there is only a spot for 65 of them.

put in one word - downregulation

 

Done that also, idk if its just this mdma doesnt work on me or what, i mean snorting gets me buzzed but never rolling. Last time i swallowed it didnt even hit me. Ill try my hardest to parachute with a shot of oj

 

Yeah I hear what you're saying, man. The trip that I was waiting 8 days for has already passed (it was the 16.5mg experiment I was mentioning in other spots on the forums--last Friday). It was a great trip, and with even more retrospect than I had when I wrote my TR, I would actually say it was hugely therapeutic.

I MAY have an acid trip toward the end of this month, if not then my next psych endeavor will be in mid-March (trying to arrange a setting) and that will be either LSD, LSD+MDMA, or LSD+2c-e.

 

Ahh cool. Fuck man, brains are nifty little sacks of fleshy-ness... cheers Pork :sunny:

 

Then your Molly sucks. Do more next time.