What drug have you yet to do, but would really like to

2-meo-Ketamine sounds intriguing if some of the anecdotal reports are accurate of it being nearly indistinguishable from Ketamine.

 

Would love to try non-extracted mescaline (peyote or other cactus) to see if it is different from the "pure" stuff, which I have tried.

I would love to try MDMA if I could ever be assured of having the real thing. I would especially love to try it in combo with shrooms or LSD.

And I would love to try 2C-B.

 

dmt, and acid

 

dissociatives have always been interesting to me, but Ive only done DXM and Nitrous.. Id say, ketamine, PCP or Muscara.. I dont think Im ready for Salvia yet ahahah

 

Mdma

 

ive always wanted to try shrooms or acid. just one time

 

Peyote for sure, I have done more LSD than I would care to know, and I loved it, last time was my 21st b-day, still did shrooms just no LSD, and I never had a bad time, I saw some crazy things but I did Acid, so when you go to grab a beer and watch the fridge melt into a puddle on the floor, it was cool not scary, I couldn't fly I took Acid. Opium was really nice but I try and avoid the narcotics, as I was an oxycontin snorter, I used to snort ritalin sr mixed with my oxy for a while, but never alone, I'm not into the speedy high, and the worst most evil drug had to be crack cocaine.Below is a really long article I thought some might find interesting it's an old post from another site and I titled it Pass the Psychedelics, I'll take the Peyote with a side of Shrooms

LSD and other psychedelics not linked with mental health problems, analysis suggests
Date:
August 19, 2013
Source:
The Norwegian University of Science and Technology (NTNU)
Summary:
The use of LSD, magic mushrooms, or peyote does not increase a person’s risk of developing mental health problems, according to an analysis of information from more than 130,000 randomly chosen people, including 22,000 people who had used psychedelics at least once. The researchers found no link between the use of psychedelic drugs and a range of mental health problems. Instead they found some significant associations between the use of psychedelic drugs and fewer mental health problems.

Researchers found no link between the use of psychedelic drugs and a range of mental health problems. Instead they found some significant associations between the use of psychedelic drugs and fewer mental health problems.

The use of LSD, magic mushrooms, or peyote does not increase a person's risk of developing mental health problems, according to an analysis of information from more than 130,000 randomly chosen people, including 22,000 people who had used psychedelics at least once.
Researcher Teri Krebs and clinical psychologist Pål-Ørjan Johansen, from the Norwegian University of Science and Technology's (NTNU) Department of Neuroscience, used data from a US national health survey to see what association there was, if any, between psychedelic drug use and mental health problems.
The authors found no link between the use of psychedelic drugs and a range of mental health problems. Instead they found some significant associations between the use of psychedelic drugs and fewer mental health problems.
The results are published in the journal PLOS ONE and are freely available online after 19 August.
Symptoms and mental health treatment considered
The researchers relied on data from the 2001-2004 National Survey on Drug Use and Health, in which participants were asked about mental health treatment and symptoms of a variety of mental health conditions over the past year. The specific symptoms examined were general psychological distress, anxiety disorders, mood disorders, and psychosis.
Armed with this information, Krebs and Johansen were able to examine if there were any associations between psychedelic use and general or specific mental health problems. They found none.
"After adjusting for other risk factors, lifetime use of LSD, psilocybin, mescaline or peyote, or past year use of LSD was not associated with a higher rate of mental health problems or receiving mental health treatment," says Johansen.
Could psychedelics be healthy for you?
The researchers found that lifetime use of psilocybin or mescaline and past year use of LSD were associated with lower rates of serious psychological distress. Lifetime use of LSD was also significantly associated with a lower rate of outpatient mental health treatment and psychiatric medicine prescription.
The design of the study makes it impossible to determine exactly why the researchers found what they found.
"We cannot exclude the possibility that use of psychedelics might have a negative effect on mental health for some individuals or groups, perhaps counterbalanced at a population level by a positive effect on mental health in others," they wrote.
Nevertheless, "recent clinical trials have also failed to find any evidence of any lasting harmful effects of psychedelics," the researchers said, which supports the robustness of the PLOS ONE findings.
In fact, says Krebs, "many people report deeply meaningful experiences and lasting beneficial effects from using psychedelics."
"Other studies have found no evidence of health or social problems among people who had used psychedelics hundreds of times in legally-protected religious ceremonies," adds Johansen.
What's the bottom line on psychedelic use?
Psychedelics are different than most other recreational drugs. Experts agree that psychedelics do not cause addiction or compulsive use, and they are not known to harm the brain.
When evaluating psychedelics, as with any activity, it is important to take an objective view of all the evidence and avoid being biased by anecdotal stories either of harm or benefit, the researchers say.
"Everything has some potential for negative effects, but psychedelic use is overall considered to pose a very low risk to the individual and to society," Johansen says, "Psychedelics can elicit temporary feelings of anxiety and confusion, but accidents leading to serious injury are extremely rare."
"Early speculation that psychedelics might lead to mental health problems was based on a small number of case reports and did not take into account either the widespread use of psychedelics or the not infrequent rate of mental health problems in the general population," Krebs explains.
"Over the past 50 years tens of millions of people have used psychedelics and there just is not much evidence of long-term problems," she concludes.
Both researchers were supported by the Research Council of Norway.

Biological basis for magic mushroom 'mind expansion' discovered
Date:
July 3, 2014
Source:
Imperial College London
Summary:
New research shows that our brain displays a similar pattern of activity during dreams as it does during a mind-expanding drug trip. The study found that under psilocybin, activity in the more primitive brain network linked to emotional thinking became more pronounced, with several different areas in this network -- such as the hippocampus and anterior cingulate cortex -- active at the same time. This pattern of activity is similar to the pattern observed in people who are dreaming.

Brain activity under psilocybin with a decrease (blue) in evolutionary advanced brain regions and an increase (orange) in memory and emotion centres.

New research shows that our brain displays a similar pattern of activity during dreams as it does during a mind-expanding drug trip.
Psychedelic drugs such as LSD and magic mushrooms can profoundly alter the way we experience the world but little is known about what physically happens in the brain. New research, published in Human Brain Mapping, has examined the brain effects of the psychedelic chemical in magic mushrooms, called psilocybin, using data from brain scans of volunteers who had been injected with the drug.
The study found that under psilocybin, activity in the more primitive brain network linked to emotional thinking became more pronounced, with several different areas in this network -- such as the hippocampus and anterior cingulate cortex -- active at the same time. This pattern of activity is similar to the pattern observed in people who are dreaming. Conversely, volunteers who had taken psilocybin had more disjointed and uncoordinated activity in the brain network that is linked to high-level thinking, including self-consciousness.
Psychedelic drugs are unique among other psychoactive chemicals in that users often describe 'expanded consciousness,' including enhanced associations, vivid imagination and dream-like states. To explore the biological basis for this experience, researchers analysed brain imaging data from 15 volunteers who were given psilocybin intravenously while they lay in a functional magnetic resonance imaging (fMRI) scanner. Volunteers were scanned under the influence of psilocybin and when they had been injected with a placebo.
"What we have done in this research is begin to identify the biological basis of the reported mind expansion associated with psychedelic drugs," said Dr Robin Carhart-Harris from the Department of Medicine, Imperial College London. "I was fascinated to see similarities between the pattern of brain activity in a psychedelic state and the pattern of brain activity during dream sleep, especially as both involve the primitive areas of the brain linked to emotions and memory. People often describe taking psilocybin as producing a dream-like state and our findings have, for the first time, provided a physical representation for the experience in the brain."
The new study examined variation in the amplitude of fluctuations in what is called the blood-oxygen level dependent (BOLD) signal, which tracks activity levels in the brain. This revealed that activity in important brain networks linked to high-level thinking in humans becomes unsynchronised and disorganised under psilocybin. One particular network that was especially affected plays a central role in the brain, essentially 'holding it all together', and is linked to our sense of self.
In comparison, activity in the different areas of a more primitive brain network became more synchronised under the drug, indicating they were working in a more co-ordinated, 'louder' fashion. The network involves areas of the hippocampus, associated with memory and emotion, and the anterior cingulate cortex which is related to states of arousal.
Lead author Dr Enzo Tagliazucchi from Goethe University, Germany said: "A good way to understand how the brain works is to perturb the system in a marked and novel way. Psychedelic drugs do precisely this and so are powerful tools for exploring what happens in the brain when consciousness is profoundly altered. It is the first time we have used these methods to look at brain imaging data and it has given some fascinating insight into how psychedelic drugs expand the mind. It really provides a window through which to study the doors of perception."
Dr. Carhart-Harris added: "Learning about the mechanisms that underlie what happens under the influence of psychedelic drugs can also help to understand their possible uses. We are currently studying the effect of LSD on creative thinking and we will also be looking at the possibility that psilocybin may help alleviate symptoms of depression by allowing patients to change their rigidly pessimistic patterns of thinking. Psychedelics were used for therapeutic purposes in the 1950s and 1960s but now we are finally beginning to understand their action in the brain and how this can inform how to put them to good use."
The data was originally collected at Imperial College London in 2012 by a research group led by Dr Carhart-Harris and Professor David Nutt from the Department of Medicine, Imperial College London. Initial results revealed a variety of changes in the brain associated with drug intake. To explore the data further Dr. Carhart-Harris recruited specialists in the mathematical modelling of brain networks, Professor Dante Chialvo and Dr Enzo Tagliazucchi to investigate how psilocybin alters brain activity to produce its unusual psychological effects.
As part of the new study, the researchers applied a measure called entropy. This was originally developed by physicists to quantify lost energy in mechanical systems, such as a steam engine, but entropy can also be used to measure the range or randomness of a system. For the first time, researchers computed the level of entropy for different networks in the brain during the psychedelic state. This revealed a remarkable increase in entropy in the more primitive network, indicating there was an increased number of patterns of activity that were possible under the influence of psilocybin. It seemed the volunteers had a much larger range of potential brain states that were available to them, which may be the biophysical counterpart of 'mind expansion' reported by users of psychedelic drugs.
Previous research has suggested that there may be an optimal number of dynamic networks active in the brain, neither too many nor too few. This may provide evolutionary advantages in terms of optimising the balance between the stability and flexibility of consciousness. The mind works best at a critical point when there is a balance between order and disorder and the brain maintains this optimal number of networks. However, when the number goes above this point, the mind tips into a more chaotic regime where there are more networks available than normal. Collectively, the present results suggest that psilocybin can manipulate this critical operating point.
The research was funded and intellectually supported by the Beckley Foundation. Professor Chialvo is from the Consejo Nacional de Investigaciones Cientificas y Tecnologicas (CONICET), Argentina and Dr Tagliazucchi is based at Goethe University, Germany.

 

Ketamine is now being used to treat depression

 

Clear crystal DMT. Only seen orange jungle extract and didn't get to try it. Damn drug hoarding hippies!

 

Mescaline, Peyote, DMT (smoke & ayahuasca)

 

Have done alcohol, weed/hash, LSD, shrooms, Nitrous oxide, MDMA But id really like to do 2cb and dmt

 

I've done some psych drugs - DMT, LSD, shrooms.
Have to say LSD is my favorite by far. Maybe because I only ever had really pure shit.
Shrooms are my least fav because of the bad experiences I had - seizures, loss of taste.

I'd really like to take Ayahuasca with a good, safe, small group of people.

 

I want to try them all, but it seems salvia is the only one I can legal order. I don't know where to get any. Guess I'll just chew on some salvia leaves.

 

PCP.

Not sure if I could do it now lol.

 

Viagra !

 

Trust you

 

I've only drank alcohol and smoked pot, but I'll try my best to try as many mind altering drugs as I can, at least once each...most likely once each. I just want to examine what they do.

 

I’ve yet to try DMT. A few friends have had experiences and all feedback has been good. Watched the spirit molecule as well which is quite informative. Interesting how it’s made as well.