If it was over working or hurting my liver in any way I wouldn't be taking them. All I'm trying to say is that Doctors frequently prescribe up to 5 750/750 vics all the time. If it was to damage your liver at these levels they wouldn't prescribe it.. I know its not as good for you as to not take them at all, but hell what is good for you anymore.. So you don't have to worry about taking 4 or 5 of those percs with 325mgs of APAP in them. And you don't need to do a CWE. But if your taking them all the time it wouldn't hurt to do a CWE if it bothers you or your worried