Quantifying The Synergy Of Suppliments

I discovered a couple of months ago that supplementing psychedelics with a dietary precursor to dopamine like l-tyrosine makes the trip more intense. In the interest of science, I propose an experiment; next time you have access to both l-tyrosine and some sort of psychedelic, take half of a threshold dose, titrate up the amount of l-tyrosine until a threshold effect is felt, then post the substance, it's threshold dose, the administered dose, and the quantity of tyrosine below (please label clearly)

I have two hypotheses:
that the intensification is proportional to an exponential function of the amount of tyrosine consumed, i.e., for some constant M, dosage equivalent=(administered dose)*2^(dosage tyrosine/M)

and

that the dilation constant M varies from substance to substance

I believe that a body of data such as this could help trippy people remain healthier, as it would reduce the amount of exogenous non-dietary material they consume.

 

you will probably have a hard time measuring "intensification" of effects in any meaningful way. you would need to give the drugs to a test subject, and then have the test subject perform some tests that were carefully designed to produce an objective measure of various aspects of intoxication.

 

While i grant that the subjective effects a la the shulgin scale would be difficult if not impossible to quantify, that's not what's being discussed. Rather, I'm more interested in the measurable physiological response at the pharmacological threshold, which is an objective albeit statistically variable limit

 

Erowid has an article that mentions an unconfirmed method of using a mix of tyrosine and dopa to boost mescaline content in a book called "Peyote and other Psychoactive Cacti".

I looked at how tyrosine is metabolized and based on that, I'd speculate the potentiation would likely be most pronounced for MDMA, Mescaline and primarily psychedelic phenethylamines, because tyrosine is a precursor to dopamine and looks like it increases norepinephrine and adrenaline as well, which this group of psychedelics is more closely associated with compared to say mushrooms. I do believe LSD has some agonism at adrenal sites and dopamine sites as well, so it too may be potentiated by tyrosine also.


Since the power of suggestion can be pretty influencing on these drugs and the test subjects will already be on one of them, if you try and formulate an unofficial study, I'd recommend having a control group given a placebo.

 

I actually first became aware of this effect when taking 500mg tyrosine on top of 25mg 4-AcO-DMT; the trip became significantly more visual, and the shroomy torso warmth became more pronounced. I then tried the same tyrosine dose on top of 125mg MDMA and it became totally overwhelming.

As most psychedelics are scheduled, it would be very difficult to set up a respectable double-blind placebo-controlled study. I don't know anyone with the time, resources and political clout to do this properly, so I'm settling on a self-reporting survey to at least get a ball-park estimate. My hope is that restricting the experimental design to the threshold range would reduce false positives and simplify data collection.

Anyone good with statistics?

 

I was fairly decent with statistics in school but it's been a few years since I've been out and I had the benefit of access to a particular statistical program we used for conducting research, which plotted all the various types of graphs, charts and bars we would want from the data input, which I do not have now, nor I do even remember the name of.

I recall it being fairly user friendly though, I'm sure there are some that are available for commercial use, maybe even help you with dealing with confidence intervals, outliers, tabbing up the data, etc.

 

If you would actually want to be able to do this type of thing legally, you might could get PhDs in pharmacology and maybe organic chemistry, eventually you will be able to pick your own research and get funding for it.

 

Why wait for a doctorate to do research?