Psychedelic Bump XI

Curious question. Has anyone tried 15-30mg of oxycodone in combination with 30mg of mxe (IM or nasal). Opiate tolerance present.

Was just wondering the dangers associated.

 

Lmao! You crack me up! I first ate Chicken McNuggets when I was 6! My grandpa bought them for me and served them with honey (My parents were to cheap to buy nuggets)
McDonalds actually changes the oil on a certain schedule. Weekly usually. This is very unfortunate knowledge, My second job 17Yrs old

 

I tried McNuggets once. I ate 2 nugs and waited about an hour, but the feeling of 'fullness' reported by quite a few other uses didn't really come to me. I was pretty foolish. I decided to eat another 2. Almost immediately after I ate the second dose, the first one started coming on.

I got so messed up that day, nugget overdoses are hell.

I had messed up bowels for a week.

Be careful with your dosage, some sources have much higher sodium levels than others.

 

lol at the sodium part!!

 

The moon is huge and beautiful!

 

tis good. i just had my first mxe experience this weekend (100-105mg MXE + 20mg 2c-e was simply magical)
I thought you(and anyone else who loves MXE) might be interested in this article about the anti-depressant properties of ketamine and how it may work. since it seems the concensus around here is that MXE is just the new and improved ketamine qualitatively, not to mention the structural similarity and probability of similar mechanism of action.
the link wont bring you right too it first its and article about mushrooms but scroll down a little bit and you will see the other link about the ketamine study
read up people!
http://www.stumbleupon.com/su/20hBx...s-can-improve-psychological-health-long-term/

 

Well then maybe I should ditch the zoloft and have the "doctor" put me on a nice regimen of mxe!
Maybe starting this week

 

People like MXE

 

It really is a super antidepressant. It's amazing! IMing doses of the likes of 30mg's or so allow physical functionality and a much clearer mind. Could not be something I would do every day but this weekend experiment has taught me a lot of lessons that will stick with me, It has been an eye opening weekend to say the least. I am grateful to have been able to experience this magic. Peace and love to all of you.

 

IMHO, though I absolutely adore MXE, NO dissociative is an effective anti-depressant, especially over the long term. This is because of their nature. First and foremost they have an anaesthetic effect. This means two things:

1.) Physically, one is completely and utterly numbed to acute and chronic pain. Extremely seductive for someone like me.

2.) Psychologically, one is completely and utterly numbed/distanced from traumatic issues or emotions.

It's just that simple. And this is the truth. Numbing is not an anti-depressive effect. It is just numbing. And distancing. I love it but I must face the roots of my depression (just speaking personally here) to have a chance at long-term healing or health. Frankly, things like LSD, 2CB, Mescaline and DMT that force me to face my stuff straight on, that hit me upside the face with it and then continue to beat. These are the things that make me weep and yell, laugh and shake. These are the things that are not numbing but in fact are healing.

Just one old fart's opinion.

I'll be taking MXE again soon, so I'd be the first to admit my hypocrasy here - I just get concerned when folks say that opiates or dissociatives are real or effective anti-depressants. They just put off the inevitable crash/self-confrontations that looms and do not allow one to face the roots and do the self-healing work.

 

Great post.
I completely agree with you.

 

CLARIFICATION PLEASE READ

Spicey, Toad, did you read the article? if so i apologize for not being clearer with my point. im NOT saying "woohoo K and MXE are ballin anti-depressants, so if your sad go do those theyre the answer!!!" NO NO NO, please do take that message away from what im saying.
I agree that the feelings of well being are due to the immediete effects of the drugs(not unlike opioids). the "numbing" as you say, at least at the physical level.
Whats i find so exciting is that researchers have been fleshing out new info about the way the brain and anti-depressants work, which in time may lead to a better understanding on the nature of depression(and all mental illness for that matter) and/or more effective anti-depressents than those commonly used today: SSRIs, SNRIs, tricyclics etc...

here is some of the article that i would like everyone to focus on:

"The researchers, led by Lisa Monteggia, an associate professor of psychiatry at the University of Texas Southwestern Medical Center, also measured brain changes after animals underwent behavioral tests. Monteggia and her colleagues found that ketamine acted by increasing synthesis of BDNF, a nerve growth factor that supports the health of brain cells, helps them grow and can promote the development of new neurons.
Some researchers have previously theorized that all effective antidepressants ultimately act by promoting nerve cell growth, which would help explain the fact that although the drugs change neurotransmitter levels within hours, it takes much longer to lift mood. Nerve cells take time to grow, they argued, and that accounts for the delay. But the rapid action of ketamine shows that this certainly can't be the whole story, whether or not the growth of new cells matters for long-term recovery.
Digging further, Monteggia's group found that ketamine increases BDNF by deactivating a chemical called eEF2 kinase (also known as CAMKIII), which normally suppresses BDNF production. Consequently, when eEF2 kinase is inactivated, brain cells produce more BDNF.
"We know that ketamine can produce a fast-acting antidepressant response in treatment-resistant patients, but no one really knows how that works. What we found is a necessary pathway for ketamine to trigger [that response]," says Monteggia. "We've identified a novel pathway never before linked to any behavior, let alone an antidepressant response — that could be a novel drug target."
That means drugs that inhibit or block eEF2 kinase could potentially work as antidepressants — ones that would take effect faster than any current medication and possibly without the "trippy" side effects that make ketamine desirable to some recreational users. Compounds like this currently exist.
"It sounds very, very exciting," says Emery Brown, professor of computational neuroscience at MIT, who was not associated with the research. "If they're correct, it most certainly could lead to new drug development. This is the first time I've heard of this possible mechanism."

Here we have some "legit" university research that to me seems to share the spirit of what Shulgin has dedicated his life too.
We all love taking mxe, K, lsd, and dmt, and 'most' of Shulgins creations, and i agree with you Spicey the dissociatives are no replacement for the true psychedelics (2 strong hits of lsd did more for me in 16 hours than years of therapy and medication, so your preaching to the choir lol:2thumbsup

The whole point of me sharing this article with you is because
1. I think its an important step in the right direction(even if its a baby step) when the medical/psychiatric community is willing and allowed(legaly) to do human clinical trials with psychedelics.
AND
2. since You, the readers and posters in this forum, actively take psychedelics. I just thought that You would find much more interest in this article than the average joe, and im confident in that assumption
​

 

I find it very interesting, don't get me wrong. I'm all for researching the properties for curing mental illness with psychedelics/dissociatives. I just think there is missing a damn important variable and that is, that all this has to be done within a safe environment. With that I mean that you need professionel supervision and controlled doses. To take drugs as a part of selfmedication is - in my opinion - playing with fire.

 

Very well said, ketamine is a very deceptive drug and I agree with what what others are saying on BL, I see many people coming up on mxe making the same mistakes I did with ketamine.

Great post spicey, ketamine/mxe may be efficient as anti-depressants in the same way daily alcohol drinking is good for your heart.

 

As stated before MXE DID help me realize my goals in life and gave me that lil extra push I needed. One should not rely on a chemical to maintain that outlook though. That is called addiction.

 

A bit of hash, and Bestival tickets

Lineup:
The Cure
Primal Scream
Pendulum
Magnetic Man
DJ Shadow
Katy B
Grandmaster Flash
The Macabees
The Village People
Fat Boy Slim
Groove Armada
Annie Mac
Skream and Benga
P Money
Roska
Skrillex
Noah and the Whale
Graham Coxen
Beardyman
Ms Dynamite
Dan le Sac vs Scroobious pip
Gentlemen's Dub Club
Willy Mason
Breakage
Goldie Lookin Chain
D/R/U/G/S
Modestep
Dr Syntax
Andy C
DJ Hype
DJ Fresh
Emelkay
Foreign Beggars
Joy Orbison
Nero
Psychemagik
Ikulele Orchestra Of Great Britain

 

MUST SEE! Hopefully Pendulum is doing a live set.

Lulz at The Village People. oliceman: :indian_chief: :biker:

 

Definitely seeing those artists, pretty much all of those are my must sees the lineup is huge but those are my interests.

The Village People are judging the fancy dress competition man!!! :afro:

 

lol Just to be clear, I don't plan on ditching my meds for mxe. Acid maybe Adele is coming to Miami in October! I <3ed her on 2c-e. And straight

 

damn it looks like a bad ass line up.