Most Dangerous Drug

You are very right about that! Here are a few of the lethal results from taking antipsychotic drugs:

1. EPS - a form of Parkinson's Disease that is incurable and essentially untreatable. Up to 50% of old school antipsychotic users get this. It is not as prevelant with the newer one's however.

2. Flat Affect leading to suicide- dopamine antagonism leads to anhedonia, the inability to feel pleasure. Suicide is not unheard of.

3. Diabetes- the new antipsychotcs, while not prone to EPS, are prone to metabolic changes and extreme weight gain resulting in severe diabetes. I myself gained 35 pounds on Zyprexa, which I am now almost done losing thank goodness. But it has been hard to lose the weight!

4. Antipsychotic Malignent Syndrome- an acute and lethal result of taking high doses (but certainly still clinically used doses , not overdoses at all) even just once. It causes rigid muscles, seizures, lethal fever, and dissociation from reality. I experienced this once and almost died. I had taken a prescribed dose of 40 mg Zyprexa in a psychotic break. It was one of the most frightening experiences of my life.

 

I'm going to have to say meth or PCP, I'm sure the cases of a bad PCP trips are exaggerated by the school, but that's the only drug where I've seen literally fucked up people out of their minds.

I'm actually kind of interested in Meth as a one time use, but I fear it's addiction, if it's as addicting as it is portrayed than I think it is one of the most dangerous drugs, otherwise I'll simply say PCP.

Actually regardless, Meth is terrible for your health mentally and physically. If I ever do try it, it'll be at old age where it doesn't even matter if I get addicted haha

 

From what I have gathered getting to know you on the forums so far, I honestly don't think Meth would appeal to you even for a one time use.

As you know, I take Dextroamphetamine daily (prescribed). According to medical literature, D-Amphetamine is equivalent in power to street Methamphetamine (however, pure Dextro-Methamphetamine from a pharmaceutical company is stronger than Dextro-amphetamine), so I can lend a bit of insight.

You seem like you enjoy the mind expanding aspect of drugs. You like to 'learn' something about yourself. Meth/D-Amph are not that type of drug at all. They consist of the following phases:

1. The Pre-Rush- soon after you take it (snort, oral, whatever...) you will feel like your senses (vision, hearing, heart rate) are amplified and you gain a sense of self-confidence and motivation unlike anything you normally have had.

2. The Rush- this is the most euphoric part and it is insanely euphoric. You feel the concentration of the drug increasing by the minute and you feel like you are in love with life no matter your objective life situation (you could be on the streets). You have great energy but it is not jittery. Again, no mind expansion however. You also are talkative and empathetic at THIS point.

3. Plateau- this is the stage where you can get stuff done. It lasts the longest of the stages. Euphoria is present but not overwhelming, so you do whatever task is at hand, and you do it incredibly well and efficiently. You are NOT empathetic at this point. You may even be temperamental.

4. Crash- unless armed with benzos or opioids you will crash. I don't get this as I take Suboxone (opioid), but I used to get it pre-Suboxone. It is nasty. You feel physically stimulated, but mentally drained. You focus abnormally long on stupid crap and tend to be rather irritable.

So that is all that Meth/D-Amph consists of really. Not very mind-opening. The only self improvement it gives is literally at the time of the experience because you can get lots of work done as well as speak confidently and openly to co-workers or just friends.

So, feel free to take it, but I don't think the legal risk of even possessing the drug is worth the high, especially since you like other types of highs more.

 

hmm Kinky Ramona, familiar name :redface:

but anyways how he/she died, like from overdose? i'm currently on painkillers right now

 

Yeah, an OD. Using prescriptions as prescribed is one thing, but when you start doing it recreationally, you start getting risky.

 

i started taking two on last thursday, every six hrs for pain. on sat i took one. im going to take one today.

 

I only took Seroquel for a couple of weeks, but holy fuck it made me want to eat. It was like weed munchies but 10 times worse. I'd never feel full, just had to make myself stop eating because I knew that I should be full.

 

It's the euphoria that interests me most (probably with most people) but here is my thinking. Opiates, like heroin and opium were a huge part of our human history. Alexander the Great and his army were using the poppy seeds of the flower and were on heroin for a lot of their battles which is why they were predicted to have done so well. Where they would have naturally have been fatigued and soar, they were euphoric and able to carry on the fight with surprising amount of focus. They then brought this flower into India where it grew even further, and the opium wars were so strong in China, it is a problem that existed ever since.

Being a natural plant, I believe it does serve a purpose. Evidently that purpose was found with Alexander the Great, but when it was used in America as essentially marijuana is, it was the horror of our country. Now meth, as I am informed, is like a "super heroin" effect where although "unnatural" it will replicate these effects to a stronger degree, and it's the history behind it that interests me most, heroin that is. If I'm going to do it though, why not do the best one? I am still in debate of this however, and will probably do heroin instead. But because of it's addictive properties, I plan to do it only at old age where it really doesn't matter.

Thanks for the effect stage though, that was really cool because I didn't hear it brought out like that before, it sucks that there is a crash period, do you know if marijuana will smooth that out by any chance?

 

I've never done meth or heroin, but I feel pretty confident in saying that the two are fairly dissimilar. They may both cause euphoria, but they do it in different ways. I don't know the pharmacology behind it, and perhaps there are more similarities than I'm aware of, but heroin is a downer and meth is an upper. They're pretty much the two opposite ends of that spectrum. If you do them both expecting anything of a similar experience I expect that you would be sorely mistaken.

 

Was it coke and meth then that are similar? I for some always displace cocaine and heroin on that scale? I'm fairly sure meth is like one of them at a stronger degree..

 

I just found out that Steve jobs also tried LSD

 

@Black Lotus:

Hi, again,

I will comment on a few things you bring up.

First, the euphoria of stimulants is produced by a different mechanism than that of opioids. I will explain in very abbreviated terms. Raw euphoria is generally thought to be the result of dopamine flux (how 'fast' dopamine molecules travel over a certain neural junction) in the Nucleus Accumbens, Olfactory Bulb, and VTA in the mid-brain. This is generally accepted for the type of euphoria we are talking about (not psychedelic euphoria which is more about coming to understanding of subtle things, etc.).

On neurons that transport dopamine, at the 'end' of the neuron, there is a membrane called a 'reuptake pump' that recycles dopamine that is lingering in the synaptic junction. This is needed to make sure homeostasis is maintained and that over-excitability does not occur. There are also membranes near the reuptake pumps that release dopamine under special circumstances. Now, the reuptake pump can be 'clogged' by certain drugs. The releasing pump can also be activated by some drugs. Drugs blocking the reuptake pump include Cocaine and Ritalin (Methylphenidate). Drugs that reverse transport (ie: release dopamine from the membrane) are things in the Amphetamine family such as Adderall, Meth, Vyvanse, and Dexedrine.

The general consensus is that drugs which allow the MOST dopamine flux in the mid-brain are the most euphoric. In MOST cases, dopamine releasing agents (meth, amph) can flood more dopamine through the mid-brain than dopamine reuptake inhibitors. Thus Adderall is more euphoric than Ritalin. However, Cocaine is special since it acts so quickly. Releasing agents generally take a little time to reach maximal effect, even if smoked or injected, while reuptake plugs can do their job almost instantly is the right substance (ie: Coke) is involved. This is why Cocaine is considered just as euphoric as Amphetamine and Methamphetamine.

The general consensus is that at the right doses and the same methods of administration (snorted, oral, injected, smoked), Dextro-Methamphetamine and pure Cocaine Hydrochloride are equally euphoric. Next in line is Dextro-Amphetamine and street Methamphetamine. Farther down is mixed-amphetamine (like Adderall) and impure Cocaine. I find that releasing agents have a bigger "jolt" to them compared to reuptake plugs.

If I compare my experiences of snorting pure Methylphenidate (Ritalin), a reuptake plug like Cocaine with my experience of snorting pure Dextro-Amphetamine, I find the two quite similar in euphoria. However,

1. The Methylphen lasts not as long, but kicks in quicker.
2. The D-Amph has more of a physical jolt to it.
3. The crash is worse on the Methyl
4. The euphoria of the Methyl is 'cleaner' than that of the D-Amph, but NOT any more or less euphoric.

Next, to the topic of opioids. They act in a complex way. In the Nucleus Accumbens (in the mid-brain), most dopamine (around 80% of it) that fluxes through it is STOPPED and 'zapped' by an inhibitory neurotransmitter called GABA. This prevents a 'short circuit' type of over excitability. So even the best Meth in the world is still subject to an 80% cut-back in power because of the GABA. But opioids inhibit up to 50% of this GABA in the NucAccum. They DO NOT increase dopamine on their own. However, since a whopping 50% of the GABA that usually zaps dopamine flow there is not zapping anything, even the brain's NATURAL dopamine flux is amplified SO much that you experience a flush of euphoria. This euphoria is very localized. Unlike 'broad spectrum dopaminergics' like Meth and Coke, which stimulate unpleasant parts of the brain (raising blood pressure, causing heart attack, etc.), the opioid dopamine is localized quite conveniently to the exact area of the brain responsible for this pleasure. It is quite scary how accurate opioids are in their targeting.

So, the euphoria from opioids is equal to but quite different than that of stimulants. The two really cannot be quantitatively compared. IMO, stimulants are more euphoric in the 'raw' sense, but opioids are more 'beautiful' and conducive to peaceful bliss rather than wild swells of intense emotions.

And, yes, all amphetamines are man-made. I am not a natural drug over man-made drug type of person obviously, but if you ARE that type of person, you would probably not like amphetamines. They are VERY man-made 'feeling'. Quite industrial almost. Opioids are very natural feeling. They feel like what one would IMAGINE a real antidepressant to be like.

I hope that answers some questions. I really cut down on the details of the pharmacology, but I think I summarized it properly. My source for the information, as it usually is when I say stuff like this on this site, is from the book "Neuropsychopharmacology" by Feldman et. al. and from academic articles found on "SpringerLink" online, a peer reviewed journal database.

 

Yes

 

Yah Meth and coke are on the same degree/scale. I'd say smoking crystal meth was a bit more stronger than snorting coke, meth definitely has sort of a more manic industrial edge to it which heavily boosts confidence as where coke is a bit more anesthetizing and 'fun' and heavily boosts ego. They both make me feel like crap in the morning after a few redoses though.

 

Yes. It is intriguing to hear that you, as well as me, feel that amphetamines have a very 'industrial' aspect to their high, whereas dopamine reuptake inhibitors (in your case cocaine, in my case insufflated methylphenidate) have less of a jolt but more of a 'natural' feeling fun euphoria.

I wonder if the majority of people feel this way??

 

In my country heroin is the drug that ruins the country most with about 1% of the population addicted to it. But i can definetily see how meth is the worst drug. It doesn't take long before a meth head is just a pile of garbage.

 

Honestly i think heroin is the most dangerous drug simply due to the fact that buying gear on the streets means you never know the purity which makes it easy to OD. When it comes down to it though heroin would be a fairly safe drug OD wise if more countries followed places like Sweden with perscribed heroin and injecting rooms to do it in, narcan on hand etc.

Meth is dangerous if your a retard and go all guns blazing smoking shards every day but the fact of the matter is you can be responsible with meth by doing it sparingly and not get fucked up!

Drugs are only dangerous if you are wreckless, plenty of people out there take drugs & not let them run or fuck up your life.

 

alcohol is the most dangerous drug,also the severity of alcohol withdrawals are a lot more acute than smack withdrawals and unmonitored self detox can kiill.thats not ta say all other drugs are safe.none are!

 

You can die from drinking 13 pints of water so, in that sense, they are all dangerous... There is one drug that I would definitely never do and it's not on the list... Look up Krokodil... Within 5 years, your skin literally rots and falls away from your bones! Got to be the worst drug ever IMO.....

 

that sounds like one bad drug so too.die from drinking13pints of water?what drinking it all in one go?