Good mixes, bad mixes

sounds like u know you're shit, bro

i recall my neurobiology professor talking about anandamide (not anandamine) being an endogenous cannabinoid that signals in a retrograde manner - or backwards from most known signaling pathways.

i don't think anandamide is a peptide though, it's just a 'chemical.'
it doesn't have any properties of a protein as far as i can see

good info though.



just being degraded by MAO, doesn't make a drug orally inactive without an MAOI, does it?
that's why you can eat something like 2ci and trip?

 

Thanks for the compliment.

I don't quite understand your question though:

"just being degraded by MAO, doesn't make a drug orally inactive without an MAOI, does it?
that's why you can eat something like 2ci and trip?"

Are you asking why ALL drugs acting on Monoamines don't get degraded automatically? I want to answer the question but (because of how lousy it is to communicate through the internet) I don't know what exactly you are bringing up.

EDIT: Also, you are correct, it is only the G-Coupled Protein RECEPTOR that is the protein. The agonist or endogenous ligand is simply a molecule that may or may not be a protein. In the case of the NMDA receptor, glutamate IS a protein AND the endogenous ligand agonist, but not usually.

 

Good Mixes
MDMA + Salvia : The ultimate psychedelic synergy
MDMA + LSD + Ketamine
MDMA + 2cb
2ce + 5/6 apb
2ce + MDMA
4 aco dmt + MDMA
2ci + 2cp
Kratom + Weed
MDMA + Methylone
LSD + DMT
2ci + 4 meo pcp

Bad mixes:
MDMA + alcohol
Cocaine + weed
Nitrous + weed

 

double post

 

do you know of any peptide ligands for GPCRs in general, or more specifically, the CB1 or CB2 receptors? i know anandamide is NOT a protein, but i'm pretty sure that S. cerevisiae mating factor is a peptide that binds to the GPCR of the opposite mating type (the lab next door to mine works on this - and a computational modeling lab down the hall works a little bit on CB1 or 2!)

my question may be best illustrated with an example)

it's thought that 2cx chemicals are degraded at least partly by MAO. but they are orally active. so it must be true that just because a certain drug is metabolized by MAO, doesn't mean that it will be inactive without co-administration of an inhibitor, right?

i think it might have to do with which isoform(?) MAO-A or -B, but i'm not sure



back on topic:
i can only comment on combos with cannabis
i've enjoyed toking with LSD, 2ce and 2cb. for LSD i usually try to wait til near the end of the experience. with 2ce, small to medium amounts of cannabis can "enhance" the experience IMO, but if i smoke too much or on the peak, it has gotten scary

2cb almost seems to have the most synergy with cannabis for me. even a hit or two has rocketed my trip in a new direction, and almost even been too much. maybe since 2cb is probably the weaker of the 3, cannabis is more noticeable on it.

 

? Nitrous and weed is my favorite combo!!

 

To each his own I guess!

It's like someone in the thread who seemed to enjoy the LSD + K combo that freaked me out so much, it's all fine. I have a hard time imagining how having my soul pushed and dragged out of my body unwillingly might be an enjoyable experience. I guess that's just me though, because I used to have this issue as a kid (unexpected OOBE's) and it left me with some very scary memories.

 

^^^you're the only person i've heard of that didn't think LSD + K was a great combo

 

My favorite combination so far was done throughout the day at a festival. All the substances combined to create a very lucid, happy, clear minded trip.

Bump of cocaine in the morning (treated like coffee)
1/16 oz of Mushrooms
Capsule of 2cI
1 Tab of LSD
.2 of Molly
1 MDMA pill
THC throughout the day

^ wasnt the plan in the morning, but it turned out to be a wonderfully balanced combination for a festival.

-tim

 

Oh geez, the last time I tried that combo I walked through a supermarket after with my friend and was so brain fried I couldn't even complete a sentence. :ack2: