Why do we associate drugs and alcohol with depression? It's usually there either way. Changes in the libido are more responsible for depression and anxiety. Those changes can take place at stages of growth or moment to moment. Embarrassment from love in the past can haunt a person into isolation, where they say to themselves well I like the attention of voices because it can be constant. Repairing old relationships can be a one in ten. If one stops themselves from wanting to be loved, which can mutate into sadness, anger, and fear, and write down thoughts that go with despair like suicidal thoughts, and keep a journal of common one's, and settle for a meditative indifference, then you can reach happiness instead of longing for a relationship you can enjoy or be zealous which is great energy or enthusiasm in pursuit of a cause or an objective. People only share to be funny about 90% of the time, which I think shows a big problem with despair of this world we have a been born into. A world of inflation. Job reduction and free bare neccessities would help. But may be the fear of children in a degenerate society holds the libido in for some people and they slip into isolation. isolation seems key to schizophrenia and the disorder may be cotemporary to society.