Drug interaction with Mushrooms?

I'm not 100% sure of the neurochem of Abilify, but I now for a fact that Xanax will NOT end a trip. AFAIK, nothing will. The only thing Xanax (or any benzo) will do is calm you down so that you can deal with it. All benzos actually work on GABA receptors (which is slightly tied in with serotonin, but not as much as people like to believe) to just help chill you out. Alcohol does almost the same thing. Actually, if it weren't for the high abuse potential and liver damage, they'd probably prescribe moonshine for anxiety.

Not really. The reason you trip is because LSD, psilocybin, DMT, whatever, is very, very closely related to serotonin. It crosses the blood-brain barrier and attaches itself to your serotonin receptors (leaving all the serotonin for reuptake). Serotonin is responsible for mood, sensation, a good bit with your 5 senses, and all kinds of other fun stuff. When (for example) LSD comes in and binds with the receptors, your brain doesn't quite know how to process it, so you end up getting mixed and/or just plain weird signals sent out to your sensory organs.

Ahhh, the joys of being a drug nerd. I need to get a degree in this shit.

 

Thanks for that response, Methanol. I really appreciate all the info and the way you presented it. So are there any drugs you would think could work for me? I get sick with alcohol. I think in my entire life of drinking, there have been three or four nights where I haven't ended up throwing up. I also generally hate the taste of alcohols. I do smoke weed, and that seems to work, but I really was looking for an effect that friends have described from MDMA and Psilocybin.

Also, is there any literature out there that would explain how Ecstasy works, specifically valid, researched literature?

 

36fuckin5, same question, do you know of any drugs that might be worth my trying?

Also, just to respond to a couple of the people from this thread, I have been attempting to treat my issues since second grade and in fourth grade was started on medication, specifically Prozac. Over the years I have gone to different doctors, and the medications have been tweaked, added, and taken away when they have stopped working or my symptoms have changed. I do have faith in my doctor as this is the most stable I have ever been in my life.

 

36fuckin5 may be well versed than I am, I really couldn't tell you for sure.

But my suggestion is things that work off other receptors. Say, marijuana, or perhaps opiates. The experience could very well be dulled by the medication, but for all practical purposes I'd say that they would still have an effect.

Marijuana acts on cannibinoid receptors, and opiates act on opioid receptors.

Beyond those staples in the drug diet, you're moving on to less used things. I'm not sure what the exact chemical mechanism of the following substances are.. maybe 36fuckin5 can provide some input.. but at least some suggestions.

Kratom, a leaf which is most often made into a tea and has calming effects.

Amanita Muscaria, a mushroom which depending on who it is you talk to, has a psychadelic effect.

Scopolamine, a chemical contained in plants such as Black Henbane. Although I would strongly recommend against this one, as it can be pretty dangerous. It is a deliriant, and causes people to not be in the real world for two days at a time at certain doses.

Myristicin, which if I am not mistaken is contained in a few various plants, including unripened mulberries (as well as the shoots and stems thereof).

I am not a huge fan of Salvia, but it's worth a try. If you don't know what salvia is, it's a member of the sage family that can be smoked or made into an extract that has extremely potent hallucinogenic effects.

The things I listed were in an effort to give you ideas for things that you could actually get your hands on. There's obscure chemicals out there, but it's quite unlikely that you'd see anything of the like.