Hi, i was trying to prepare it, but it seems to me it is contaminated with salt probably... at the final step, i evaporate it completely, as they recommend... when i was trying not to evaporate completely, the purity was better but the yield was extremely low after crystallization... even when i left it in a fridge for a looong time. did anybody of you prepare pure carboplatin? ([SIZE=11pt]Inorganica Chimica Acta 359,[/SIZE][SIZE=11pt] 2006, p. 4095–4104[/SIZE]) i followed this: 1) Ag2R(COO)2: Two millimoles of aqueous NaOH are added to 1 mmol of the dicarboxylic acid dissolved in a small quantity of water. Two millimoles of AgNO3 are then added to the sodium dicarboxylate solution in the dark. A white precipitate forms immediately. The mixture is stirred for 15–30 min and the silver compound is filtered, washed with water, dried in air and finally in a dessicator. The yields are between 60% and 80%. 2) Pt(amine)2R(COO)2: The two compounds cis-Pt(amine)2I2 and Ag2R(COO)2 were mixed together in water in a 1:1 proportion. The mixture is stirred in the dark during 2–3 days until the formation of AgI is complete. The yellow precipitate is filtered out and the filtrate is evaporated to dryness.
for real for real , op might be on to something.. http://www.carboplatin.org/ Another good thing about carboplatin, compared to some of the new drugs, is that it is not patented (the patent has expired) and therefore cheap. With new targeted therapy drugs going for $50K/six-week regimen and carboplatin coming in at under $2K, the cost difference is striking.
