advice needed please

Discussion in 'Drug Chemistry' started by kye, Mar 10, 2014.

  1. kye

    kye Guest

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    so theoretically there is copious amounts of amphetamine sulphate, but no one likes it! they want methamphetamine or mdma, is there any fairly straight forward methods this could be accomplished? any ideas for any substitute amphetamine(or cathione, phenalthymeine etc) are more than welcome, (mdma would b a definate favorite but a decent synth with easy to obtain chems for anything similar would be aprerciated)

    Thanks in advance
    kYe
     
  2. kye

    kye Guest

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    i'm thinking something along the lines of:

    Formaldehyde and Aluminum Amalgam1

    N-Methyl-amphetamines were prepared by the reaction of the corresponding amphetamine with formaldehyde and reduction in the absence of acid. Thus, a mixture of 1 mole amphetamine freebase (136g) and 1 mole aqueous formaldehyde (81ml 37% or 75ml 40%) in 350 ml alcohol and an excess of aluminum amalgam was reduced for several hours, water added, aluminum hydroxide filtered off, the solution acidified and evaporated, and the freebase separated by means of alkali yielding phenyl-N-methylisopropylamine, converted to the hydrochloride, mp 140°C. Similarly, 70g d-amphetamine in alcohol with aluminum and 1 mole formaldehyde gave d-methamphetamine, which was converted to the phosphate salt. 1-Phenyl-2-aminopropanol similarly yielded ephedrine.


    What dyas reckon? seems easy enough? havta make the aluminium amalgam but that seems pretty simple too, apart from the sourcing of HgCl2,
     
  3. kye

    kye Guest

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    sorry, just realised i posted this in Psychedelics instead of drug chemistry, if a mod could move it thatd be good thanks,
     
  4. kye

    kye Guest

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    nobody any ideas what to do with this theoretical stuff? must be someone still on here with the knowledge?
     

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