The fridge is fine, it really depends on what chem you are talking about. eg DOC HCl would be very stable, where 4-aco-mipt will degrade fast.
i've noticed both my 2c-e and 2c-b seemed to have turned a little yellow since i've had them. i've only kept them at room temp though.
i thought that was only for tryptamines not 2c's but as it appears i might have been wrong on that one.