hydrocodone & ADD- Do you experience Both?

Sorry, your wrong. It is active when drank as a tea as well.

Edit * Sorry, you are not actually wrong, smoking is one of the ways to receive effects. But is active orally as well, that's all I meant. And yea, oxycodone does come from Thebaine. If it came from Morphine, it would be called Morphine, or, Ms Contin

 

you won't really get much of an affect from it anyway, being that the effects of thebaine are cancelled out by the effects of codeine and morphine; interesting, since all three are morphinans.

oh..and oxycodone can be produced from codeine... it goes as codeine-->codeine methyl ether--> thebaine

thebaine is dissolved in formic acid treated with h2o2 to give 1,4-hydroxycodeinone, then neutralized with naoh and hydrogenated to yield oxycodone.

hydrocodone can be prepared from codeine via catalytic hydrogenation to give dihydrocodeine, which is then treated with potassium tert-butoxide in benzene and refluxed.

 

Well, I dont have much experience with smoking, but thebaine would still work in tea wouldnt it?

 

thebaine has a stimulant effect; I suppose if that odd sensation at the back of the head is from thebaine, then yeah. tea made me feel relaxed, but gave me a strange "pain" in my head.

 

yea, i thought so. You felt it too? Like down by your neck almost?

 

yes.
smoking didn't quite give the same sensation, and the effects weren't as long.

 

I thought thats what it was, because the euphoric and talkitive sensations I got lasted for a LONG time, which i attributed to thebaine, then the relaxation/werid dreams came on and lasted into the next day. (well, the next week really, because i kept drinking it)

 

I was under the impression that when thebaine is categorized as a stimulant it is with respect to respiration. Maybe it also has psychostimulant properties?


A few times on smallish doses of hydrocodone or oxycodone I have noticed a biphasic response, where an initial stimulus feeling is followed by the more typical opiate relaxation. Larger doses never brought about a stimulant state, and small doses only did sometimes. I suspect it has a lot to do with how the drug acts on the dopamine system.

Now only if we could find someone to fund a study exploring standardized thebaine only, codeine/morphine only, and thebaine/codeine/morphine combinations.

 

Yea, didnt you ever have trouble sleeping on certain pills?

 

With amphetamines, yes. I have only little experience with hydrocodone and oxycodone. A few times I had difficulty sleeping on small doses. Could be coincidence or could be that opioid receptor agonists dose dependently prolong calcium elicited action potential duration, and at higher doses shorten the action potential duration.

 

(+) thebaine binds mu (most effectively), delta receptors and has antinioceptive activity.
(-) thebaine binds mu, delta (most effectively) receptors, lacks antinioceptive activity, and the principal behavioral manifestation is lethal convulsions.

European Journal Pharmacology. 1998 Jan 22; 365 (2-3): 143-2.