Ayahuasca has always given me very nice experiences, but sometimes it can get a little too weird, and the effects are often unpredictable. But, I have done LSD, shrooms, mescaline, bufotenine, DMT + 5meo-DMT (free based), an array of psychedelic amphetamines, LSA, and yet and still, nothing has come close to Ayahuasca. Although basing DMT was pretty intense and crazy, it wasn't as fun and interesting as some ayahuasca experiences I've had. I always use mimosa hostillis and syrian rue in my ayahuasca, and I firmly believe DMT alone cannot account for the effects of a mimosa / rue brew. I really wish I could find more information regarding exactly what alkaloids are in mimosa hostillis.
for the actual trip, shrooms or dpt. for the larger picture, nothing comes even remotely near being even remotely near LSD.
MDMA isn't a psychedelic, it's an empathogen. For me, nothing comes close to LSD. The visuals, the euphoria, everything. It just can't be beaten.
My fave has to be shrooms, due to the kaleidoscopic, spiritual mind-fuck. Second is a tie between 2ce and LSD; both for different reasons. LSD for it's liquid, colorful nature. 2ce for it's electric/mechanical chaos.
Either 2C-B or mescaline. I haven't had a good, proper dose of mescaline yet, but it seems to be the best.
the synergy between 4-aco-dmt and 2c-c seems to be a chemical all it's own.... i pick that one. ...but this changes a lot...