Anti-psychotics and psychedelics interactions...

Was wondering if anyone knew the effects of an anti-pyschotic drug, ie Seroquel, when taking drugs such as shrooms and MDMA...? Seems like the anti-pyschotic cancels out the effect of the shrooms significantly if eaten while trypping. Even if I havent had one for 18-24 hours it still makes the shrooms weaker. How long would i have to be off them to make the shrooms or other psychedelic have the full effect. Unsure what the effects are when taken in combination with MDMA, havent been game enough to try yet. Also would it effect amphetamines effectiveness....? Does anyone know what the score is.....

 

Anti-psychotics will block the effects of all psychedelics. I would also recommend that you do not discontinue your meds without talking to your doctor.

 

yeh you cant really take drugs if youre on antipsychotics except downers id imagine

 

would anti-psychotics help one feel more 'in reality'?

 

I take remeron 45mg every night, xanax in the day, + ate shrooms many times with this combo with no problems. Trip was as great as it was 14 years ago.

 

I think Seroquel would negate any amphetamine. I'm not sure how long it takes for Seroquel to quick working or be eliminated, probably at least a few days depending on the plasma concentration.

 

Remeron and Xanax are not antipsychotics. I'm glad you had a nice trip though.

 

Would you just pass out?

What about dissociatives? I had a chance to sample Zyprexia and there was something about it that reminded me of NMDA antagonism.

 

From what I have experienced that seems to be the case....

Yeah you feel quite sleepy if you take to many, as for dissociatives have only tried NOS while on them and that works quite well.....

 

I still don't know, NOS = ?
nitric oxide synthase is the only thing that comes to mind.

 

i was wondering that myself...

 

does he mean nitrous

 

traditional antipsychotics such as chlorpromazine and haloperidol were D1 (dopamine 1) antagonists, commonly referred to as "neuroleptics"; they competitively bind to the dopamine receptors in the basal ganglia, and long term use may result in tardive dyskinesia, parkinsonian-like symptoms.

modern antipsychotics like seroquel actually bind to D2 receptors, and don't really give those side effects.

 

Anti-psychotics are one of the more potent perscription medication. They will make you feel drunk and disoriented and most people can't do much of anything while on them. One major side effect is the severe leg twitching or spasms. You may lose any appetite and your blood pressure and temp may rise.

 

I agree the newer anti-psychotics and neuroleptics do not alter movement nearly as much as the older ones. They all cause sedation though there has been some improvement, presumably due to the more refined antagonism of dopamine receptors. It would be interesting to know what drugs augment the classical psychedelics. Those that antagonize 5HT2 receptors and dopamine receptors should completely inhibit a psychedelic experience. yet it isn't always so cut and dry. What about drugs that act on 5HT1 or 5HT3, norepinephrine, gaba, or glutamate? Drugs such as buspirone, ondansterone, atometoxine, gabapentin, lamotrigine.