opiate lounge

i did too much needed to quit.

 

Hi every1... Finally a place with ppl I can relate 2... I've been on opiates (mainly hydrocodone) for almost 8yrs 4 a chronic pain condition but over the yrs my tolerance has gotten way outta control & I keep running out... I used 2 live in a place where I knew ppl & have recently moved & it sux so bad cause I don't know where 2 even start here... U don't wanna ask just any1... Well, I won't bore u all with the details just wonderin if any1 has any advice or has had this problem... This is a 1st 4 me...

 

Nice to meet you. What is you condition? I'm also a CPP. And man only hydro after all those years I'm surprised he hasn't moved you up. And I wouldn't really mention about sources on here this isn't that kind of site. We don't discuss anything illegal on this site. But heck this is all hypothetical anyways so I guess it doesn't really matter.

 

I've been on Hydrocodone since 2003. I know that's a long time. I have labs about 4 times a year where they check for liver and kidney problems, among other things, and so far my liver is ok. Still though, I've thought about asking my doctor to put me on Oxy, at least the 20's. I started on 90 5mg Hydro's per month, then 120 per month, and then 150 10mg Hydro's per month. There's not much farther I can go before I hit the ceiling for Acetominophen. Maybe 180 per month, but that's not going to help much. Unless I could get switched to the 325's, in which case I could maybe go up to 240, but I don't think the VA even has those.

 

Well i,m still clean of herion, i,m bout to break a month here.this suboxone is a wonderful drug. It was like when i first tryed herion i never looked back, when i started the suboxone program i never looked back to herion. but i know i,m not REALLY clean the sub is a drug it,s self, i traded one for a safer, cleaner, legal drug. but it really helps with ma anxity i go out in public more often, and it helps with depression but i think i need something more to help with that(it,s been worse since ma dad killed his self and his side of the family come and took his harley from me (he put the title it in his sister,s name days before, so he really did hate me.) told me they don,t want me to be a part of there family anymore.they were a big fam. 8 uncles and kids? there all around this little town of probally only 2,000 people. all i have left is ma crazy mother, and gram and pap but there old 85-80 they raised me i never lived with ma mom and dad. and of course ma new family that we started ma old lady and 2 kids there all i need to worry about. whoa this is the opiate lounge i started ranting off. oh well thanks fer hearing ma shitstorm.

just took 4mgs of suboxone it isn,t helping with the knee pain anymore much or there my knees are getting worse and can,t take otc pain shit because i still drink more than i should and any of that shit don,t do anything for the pain anyhow.

 

Keep at it stoner. I feel you about not looking back. I got off of a huge oxy habbit with subs two years ago and have never ever looked back..
Try getting them knees stronger. Maybe some kind of physical therapy.

Im currently interested in getting off suboxone but am in no rush.
keep at it bro!!

 

thanks midwestcaveman and good for getting clean.the subs are a mircle. i tore the cartlige and had it removed in both knees, and tore the acl ligment in one when i was 16. they told me then i would need a knee replacement by age 35, my sub doc said i have the knees of someone in there 70s cause of arthits and 2 nice bone spurs or calicum build up( hard bone sticking out on the side of ma knee).

i heard there might be something they can inject into your knee like silicone, anyone know anything on that?

but took 6mgs this morn. of ma subs,...happy memerioal day everyone have a great weekend.

 

One of the most fascinating aspects of agmatine, an endogenous molecule, is its ability to potentiate the analgesic
effect of morphine while also reducing morphine dependence and withdrawal symptoms. At the same time, agmatine
has absolutely no effect in naive animals on behavior,

locomotion, or cardiovascular functions. Here, therefore,
we have the opportunity to manipulate a system that is activated only when the normal homeostasis of the brain/cells/
neurons is altered, for example, in the hyperexcitable state

after chronic morphine exposure. Moreover, as agmatine
has multiple molecular targets with low affi nity and, thus, is
easily reversible in functional actions with no toxic effects,
it has tremendous therapeutic potential. The use of agmatine

by itself or along with selective agmatinase inhibitors will
be a valuable therapeutic approach for several targets, in -

cluding ischemic injury, convulsive seizures, and opiate analgesia with reduced risk of dependence.

 

http://www.bluelight.ru/vb/threads/625780-Hydrocodone-raised-to-schedule-2-in-US[/URL]

 

damn, i thought ETK would be all over this, i even broke it up for u to read as i know u dont like to read 1' long paragraphs, lol

and i have no idea where Bottle is.......

 

PORK!! I am here and ready to respond!

The reason I have been absent is due to my grandmother's recent surgery to resection her transverse colon due to Stage IV colon cancer. But she is recovering now and I can get back to normal life. I am so happy she lived through the procedure though. And best of all, she will not need a colostomy bag!

As for Agmatine, pork posted a complete confirmation of what I have been saying for years here. So to the doubters of my information, look at his link (it is not associated with ME whatsoever). There are also at least five peer-reviewed citations about Agmatine on tolerance that I will try to post here in a bit. The problem, however, is that now that I am not an instructor at the University of Delaware, I lost my privileges to use the journal database.

Here is why Agmatine Sulfate works:

1. Tolerance to Opioids and to Dopaminergic Stimulants (ie: amphs and cocaine) comes about due to something called Long-Term Potentiation. This is a process in which, when a neuron is subjected to the same pharmacological stimulus over and over again, it reacts by down-regulating the number of receptors associated with the drug.

2. The mechanism of LTP is too complex to post in a short reply (it can be found in a very good, but a tad technical article on Wikipedia titled "Long Term Potentiation") but it involves, in its deepest form, the over-excitation of NMDA receptors from glutamate (which is released indirectly by opioids and stimulants in the Nucleus Accumbens due to stimulation of D_3 receptors).

3. Agmatine Sulfate is an NMDA receptor antagonist and a Nitric Oxide (not NitROUS) pre-cursor. And unlike many NMDA antagonists, it is not psychoactive at all. This is due to its functional selectivity on NMDA receptors outside of the cortex (look up "Functional Selectivity" on Wiki). And Nitric Oxide is also responisible for tolerance reduction in some COMPLETELY unknown manner! I honestly have NO idea how it works.

4. Since it is not psychoactive, large amounts of Agmatine, say 1.0 - 1.25 grams, can be taken at once, allowing for ridiculous saturation of NMDA receptors.

5. With the NMDA system (glutamate system) hijacked, the brain "forgets" about all the LTP that occured even if it was over decades! Thus, in a few days at most, one can get their opioid or stimulant tolerance under control and even reverse it to a significant degree.

I hope that helps. Thanks for the link, pork! I hope that others get their hands on Agmatine, because it really takes away the MAJOR aspect of why opioids are so dangerous: TOLERANCE.

 

Whatup? Anybody here live in Dallas? Holla at yo boy.

 

After a bit of research, I found the below-
-----------------------------------------

>One of the most fascinating aspects of agmatine, an endogenous molecule, is its ability to potentiate the analgesic effect of morphine while also reducing morphine dependence and withdrawal symptoms. At the same time, agmatine has absolutely no effect in naive animals on behavior, locomotion, or cardiovascular functions. Here, therefore, we have the opportunity to manipulate a system that is activated only when the normal homeostasis of the brain/cells/neurons is altered, for example, in the hyperexcitable state after chronic morphine exposure.
Moreover, as agmatine has multiple molecular targets with low affinity and, thus, is easily reversible in functional actions with no toxic effects, it has tremendous therapeutic potential. The use of agmatine by itself or along with selective agmatinase inhibitors will be a valuable therapeutic approach for several targets, including ischemic injury, convulsive seizures, and opiate analgesia with reduced risk of dependence

I'm far from a chemist, but as a long time,, older, opiate dependent person (methadone maintenance) I found this an interesting read

jack

 

That's what Porkchop posted.

 

Very interesting,from what i read can the agmatine itself help to reduce some of the really bad w/d that most of us go through,like when i run out of fentanyl patches early?That would be great,that stuff would fly off the shelves,or am i missing something?It cant be my mind thats missing,i lost that years ago and it aint coming back.

 

hAhA- i GUESS i SHOULD READ MORE of THE POSTS before I start typing

 

lol,oops.After going back and reading more,thought i would see if i could locate some agmatine sulfate,the one place where i did order supplements just started selling this stuff recently,thirty dollars for 120tabs,which is suppose to be a months supply by thier recomendations at iherb.

 

etkearneeeeeeeee where are you mannn

this forum needs you back posting to bring this community back from the dead

 

Hydropersistent seems to be mia as well.

 

What's up everybody