MAOI's: The Money Saver & Safe Drug Potentiation

So SWIM was recently prescribed MAOI's, and SWIM has always enjoyed rolling on the weekends and occassionally trippin on some good acid. Anyways, SWIM is conducting an experiment on how to safely use MAOI's for potentiation/amplification of other drugs in a SAFER manner. It's lengthening and strengthening effects on other drugs could also make it a HUGE money saver.

SWIM's Results Thus Far:

* 1/2 MAOI Pill + (30 Minutes Later) 1 Bowl of Bud: High like really high, the kind of high from smoking a lot lot lot of quality kush. Seemed to last longer too. Munchies definately stronger.

* 1 MAOI Pill + (30minutes Later) 1 Bowl of Bud: Simply put. Most baked SWIM has ever gotten.

From here SWIM wanted to try something stronger, but not possible to overdose on: Acid

* 1/2 MAOI Pill + One Dose: Tripped Balls like crazy for like 12 hours and still tripping into sleep.

* SOON TO COME:

* 1 MAOI + One Dose
* 1/2 MAOI + 1/2 of a Bean (SWIM WOULD LIKE OPINIONS ON THIS ONE IF MAYBE SWIM SHOULD TAKE AN EVEN LOWER DOSE OF THE ROLL)
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That should be an ok dose with the Roll, I'd make sure you have good clean rolls though.

 

You don't need to say "SWIM". We all know it's you.

 

Hahaha sorry used to that. Yeah we get real high quality rolls out in chi city so I'll be sure to let you all know my result, probs by Saturday night.

 

Have we all forgotten that MAOI + MDMA = Serotonin Syndrome?

 

He isn't getting serotonin syndrome off ~50 mgs of mdma Writer.

 

I would be VERY careful mixing MAOIs with pretty much any drug. Any drug that potentiates Serotonin, Norepinephrine, Dopamine, or Histamine is going to reach DANGEROUS levels if combined with a non-reversible MAOI like Nardil or whatever.

Mixing it with Cannabis is fine since Cannabis does not act on the Monoamine chemical transmitters. Your 'extra high' is simply the combination of Cannabis with having excessive amounts of Serotonin, Norepinephrine, and Dopamine in your brain at the same time. It actually doesn't potentiate it at all in a strict sense.

 

^ It's necessary to take MAOI for DMT and DPT to be active orally. It's fairly common practice among psychonauts to take MAOI with various serotenergic hallucinogens: DMT, mushrooms, LSD, mescaline, etc.

There are two types of MAOI to my awareness and that seems to be more of an issue, do you know anything about that etkearne?

 

Yes. I know that oral DMT has to be taken co-currently with an MAOI, but the OP seems more interested in other drugs, at least, the username indicates such. Just my perception though, perhaps I am wrong. The reason for the DMT thing is that it resembles the serotonin molecule geometrically, and would be treated as such in the gut, and would get broken down.

There ARE two types of Monoamine Oxidase Inhibitors. The first type, MAO-A Inhibitors almost exclusively inhibit the breakdown of Serotonin and Norepinephrine. They are considered more 'dangerous' for the dietary restrictions. They were the more 'old-fashioned' variety of MAO I's. The second type, MAO-B Inhibitors work mainly to prevent enzyme breakdown of Dopamine and to a lesser extent Norepinephrine. These drugs are still used semi-regularly (at least compared to MAO-A's). They do not carry the strict dietary restrictions, but they could easily kill you if taken co-currently with ANY drug that significantly alters Dopamine levels. For example, if I were to take Selegine (an MAO-B) right now, I would easily die, because I took Vyvanse (dextroamphetamine) this morning (like I am prescribed...) and that drug releases Dopamine.

Normally, a good amount of that dopamine released by the D-amphetamine would get broken down quickly, by the MAO enzyme. But having an MAO-B Inhibitor would inactivate the enzyme, leading to almost an infinite cascading increase in brain dopamine levels. This would cause your heart to explode to put it bluntly. Also, amphetamine releases Norepinephrine, so that would just add to the danger. I also take Effexor an antidepressant (that I take for anxiety- it doesn't work for depression in me) that allows for higher concentrations of serotonin AND NOR. So, I would be having multiple heart crises before I died haha.

 

I'm either still got too bad of a headacheto find the edit button or I can't edit my post. BUT! The headache is good news. I did the half bean/ half maoi and I'm alive. It felt like single dropping but lasted much longer like 8 hours and I peaked for like 5 or 6 of them. Crazy ass shit though. The comedown kicked my ass though. Hence the headache.

 

Bad idea even with 50mg of MDMA, the headache is a direct sign of the neurotoxicity you potentiated with the MAOi. I wouldn't make this a habit.

 

Kudos for braving such 'dangerous' waters so some of us have a better understanding of how these things work.

What is your Maoi supplement that you are using?

 

I use Hydralazine (Brand Name: Apresoline)

 

So, are you scripted this MAO-I or do you just obtain it off the internet (I'll admit, I have gotten non-scheduled scripts from the internet...)? Although it is a very interesting adventure you are taking, I really hope you keep in mind the seriousness of it at each new experiment. I mean, it seems like right now that you are well-aware of the consequences, but just don't want to see you run into a medical crisis because you let your guard down at some point.

Most of all, be sure to post and sum up any new combinations you try. These are like the medical experiments that are too unethical to actually perform on people haha.

 

an upper and a maoi sounds like a deadly combo to me. That hydralazine is nasty drug. common side effects according to wikipedia: Drug-induced lupus erythematosus , Vitamin B6 deficiency, ANCA-associated Vasculitis and shit like that. I think it should be avoided. I hope you did your research too and know what you are doing.

 

Yes I am indeed scripted. And will be adding more experiements to come =)

 

Curious, how does the MAO-I help your depression and/or anxiety symptoms in comparison to other antidepressants. I have taken the following for depression:

SSRIs - did not work at all
SNRIs - Cymbalta worked somewhat, Effexor (still on) helps anxiety but not depression
TCAs - Amitriptyline (sp?) helped a little bit but side effects were strong
Stimulants - Ritalin (Methylphenidate) worked a little bit, Adderall/Vyvanse (still on Vyvanse) works VERY well
Opioids - Off-label prescription of Suboxone (Buprenorphine) helps MORE than anything else.

My doc and I discussed switching to an MAO-I, but since the combination of the stimulant Vyvanse and low-dose Suboxone work so well, and since I take other meds that would negatively interact with an MAO-I, we stuck with the current regimen.

 

@etkearne: MAO-I's are the most effective antidepressant, but come with the most health risks and lifestyle/dietary restrictions.

What the drug does though is it stops production of mono-amines (things that destroy unabsorbed neurotransmitters of every type). Hence the best long term anxiety/depression medication. And the boost it gives to psychedelics!

 

This one was a fun one:

I came across rolls that were 100mg MDA.

Half a roll was consumed with half of my MAOI.

***FUCKING CRAZY ASS 12 Hour roll. My god, I may like MDA more than MDMA.

@Mr. Writer: No hangover this time. I think I was dehydrated from the MDMA trial, thats all. Plus lack of sleep.

Money Saved this past weekend: $40 (And I still have half of the roll left)
- I normally double drop and single drop 90-120 minutes in.

 

Also, trying shrooms this weekend with it!