MDMA from Methylone?

Discussion in 'Drug Chemistry' started by The Flow, Nov 17, 2005.

  1. LoC

    LoC Member

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    He was probably talking about the Clemmensen Reduction.

    More: http://www.organic-chemistry.org/namedreactions/clemmensen-reduction.shtm

    Yep, I think that's the one you'd want, particularly the Huang-Minlon mod. The essential chemicals I think would be particularly easy to acquire if using the modification.

    For a little more on it: http://www.organic-chemistry.org/namedreactions/wolff-kishner-reduction.shtm

    Any smarty-pantses out there have ideas on the ratios of chems here? How much solvent to use? What kind of glass setup would be needed? Hopefully not a distillation apparatus... eek. That puts this out of the range of most people's budgets right there...
     
  2. SplitOpenAndMelt

    SplitOpenAndMelt Guest

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    wolff-kishner reduction?

    :deadxmas:
     
  3. fryingsquirrel

    fryingsquirrel Member

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    Creating an alcohol might not be a bad thing, once you had MDephedrine several options are available. Just a matter of finding one that won't damage the MD ring.
     
  4. Hedgeclipper

    Hedgeclipper Qiluprneeels Nixw

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    I've only got highschool chemistry, too, but I've got a fumehood. :D
     
  5. LoC

    LoC Member

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    Here is Shulgin performing the Wolf-Kishner reduction (Huang-Minlon mod) to get 2,5-dimethoxy-1-ethylbenzene from 2,5-dimethoxyacetophenone.

     
  6. Droid

    Droid Guest

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    ... theres a muuuuuuuuuuuuuuch easier way to do this. which i came up with... and by came up with i mean found by spending hours reading articles and learning about electrophiles and aryl compounds and catylists.

    anyways:
    Methylone+H2 over a nickle (II) catylist.
    cu/pd rainey nickle rhodium ext can all be used but the non nickle ones might fuck up the benzene ring into cyclohexane also pressure is needed apearently i dunno some sites dont specify and others say conflictign things. the only one im sure about is using a nickel silicon catylist at 90C.
     
  7. jiveturkey

    jiveturkey Guest

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    Can anyone confirm this?
     
  8. LSDMIKE

    LSDMIKE Member

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    or simply a microwave

    the same way you make pseudoephedrine to ephedrine

    none of you seem to understand chemistry just about making drugs

    and most of you dont even know how to do that!

    and thats good yer

    YES
     
  9. alex211

    alex211 Member

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    what about either a Clemmensen or Wolff/Kischner reduction? both are used to make ketones into alkanes. i know Clemmensen rdxn is in acidic conditions and Wolff/Kischner is basic. but these might fuck with the diether bridge. this could also work making methcathinone into meth, if it works at all
     

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