suboxne...less is more?

hey guys Ive been trying to figure this out lately and most of it is just what i read online or hear say from other people. but suboxone is a semi synthetic opiate that has (an opiate blocker?) Nalaxone in it. but the nalaxone is only effective at a higher dosage. so when you only sniff 0.5mg - 1.0 mg of suboxone you are getting the opiate high and there is not enough nalaxone to block it? if i am wrong please let me know i am just trying to familiarize myself with the drug

 

Yea From What I heard U can Take Up To 2mg Without the Nalaxone Being Effective...And Yes This Is Probelly The Only Opiate That Less Is More!!!!U Should Try Subutex!!! They R the Best!!!

 

No Nalaxone At All!!!Just Pure Buprenorphine!!!

 

Nalaxone high little to no bioavailability sulingually. Also, when prescribed, people take like 50 mg of Nalaxone, not the 1-4 mgs that a person using Suboxone would encounter. Nalaxone has some BioAvail. orally, but STILL is immensely overshadowed by the agonist power of the Buprenorphine.

Snorting it is similar to sublingual. However, if injected, nalaxone has 100% bioavail. and thus, could, in theory exhibit a slight antagonists effect to the buprenorphine. That is why it is put in there.

By taking it sublingually or intranasally, the effects of the Nalaxone are nil.

 

in all honesty, suboxone and subutex are the same things. the naloxone doesnt do anything to block the buprenorphine if you decide to shoot it (that is, if your into that sort of thing. i know different people are into different roa's but i dont judge people).

my brother himself has shot suboxone before and it worked perfectly fine for him, no withdrawal symptoms or nothing like that. apparently the reports that you cant shoot suboxone because the naloxone will send you into withdrawal are just scare tactics.

 

Exactly. Just look at the average dose of Naxalone for people who take i therapeutically. It is like 50 or more milligrams. And an 8mg Buprenorphine Suboxone only has 2mg of Naxalone.

 

i was wondering what the ratio of buprenorphine/naxalone was in the 8mg pills.

so if these are made for people trying to kick opiate addiction do they have to eat 25 pills just for the nalaxone to work? seems to me like it is defeating the purpose

 

You pretty much have it right. The naxalone is essentially an 'idiot-proof' deterrent. The pills always come in a 4:1 ratio, so 8mg Bupe/ 2nd Nax , etc.

 

well i think they need to re define their definition of deterrent because it only takes me the tinyest little bump from the suboxone to get high on it. seriously if i do more than a .5mg line im throwin up.

 

Yeah. The biggest controversy in the Suboxone world is having it get into the hands of people without heavy opioid tolerances. 2mg of Suboxone is equivalent to 80mg of morphine (from my opioid conversion app), so one must be very careful if they want to enjoy Suboxone without getting sick if they have no big-time tolerance. Pretending like Suboxone isn't a real opioid by doctors is silly. I have gotten so high as a kite off of (extra) doses of it that it compares to the strongest pre-treatment highs.

 

If you want to take any other opiates after suboxone wait at least 24 hours or you'll waist the other opiate. I have to wait at least 72 hrs (I found this is best for me) b/c I take 32mg a day and the suboxone has a very long half life.

As far as subutex they gave me that when I had surgery so the suboxone wouldn't block the diladid and Ketamine.

I like suboxone better than subutex personally but if you want to use other opiates at the same time use subutex.

 

Oh yeah and naloxone helps the itching that opiates cause.

 

if im not taking enough suboxone to have a legitimate amount of nalxone in it then it wont matter if i do any other kind of opiate will it? because i have done my small dose of suboxone and then sniff half a roxi 30 the next day and still feel good off of it.

 

I remember one time I was tripping on dramamine and I "wisely" decided to snort three suboxones. The dramamine eliminated any nausea and I was FLYING.

To say the least, I more than paid for it the next day.

 

I think that's one of those that just depends on the person. I have a friend that I would literally give a crumbs to and she and her bf would do 80mg of oxy 12 hours later and they would feel it but it was like taking 10mg tab and they got mad at me because I said with that little 4-8hrs should be fine and I thought it would be. I can't take under 2mg because anything less has yet to do its job so I never thought about the naloxone not being prevalent I just know how long to wait for each mg for me. I have wasted a lot of goodness figuring it out too but to each their own.

 

The naxalone is not responsible for your subjective effects unless you are banging it. Period. (Even then, you need a lot of it).

However, Buprenorphine (the opioid part of Suboxone) has a ceiling effect. At around 4-6mg, taking more and more buprenorphine will NOT increase one's subjective opioid effect (ie: you can't get higher than 4-6mg of it would allow for). So, if you take 200mg of Oxy a day, which is eqivalent to about 10mg of Buprenorphine, you will already be tolerant to the 4-6mg ceiling dose, and thus, could take it and seemingly not be high.

However, a person who only takes, say 40mg Oxys once in awhile, need only take 1 or 2 mg of buprenorphine to get that same opioid effect. And, for that person, that opioid effect is strong.

 

This basically sums of what I was going to say.

 

wow etkearne thank you very much!

 

ya less is more...im prescribed and if i take over a fourth i just feel like shit...but if take a crumb in the morning i get a good buzz to start the day

 

I am glad I could provide some assistance here! Feel free to ask me any more pharmacological questions on opioids. I also am pretty well-versed with stimulants, psychedelics, and GABA-ergics (downers).