Hello All: I just had a question for anyone who may have some knowledge regarding Savella. It is a drug used for Fibromyalgia called an SNRI. My gf just started using it for the treatment of fibromyalgia. I have done some research and apparently it would be unwise to roll while she is on this medication simply because either she may not feel the effects of the mdma or even worse serotonin sydrome! It is a drug not used primarily for depression but acts in the same ways as an antidepressant would to hopefully eleviate the way the brain interprets pain. Anyway, I like to refer to us as pt partiers We have a kid so we do not party very often but enjoy it very much. Anyway, just a few questions: has anyone heard of or had any luck with this drug? If so, am I correct in saying that being that it is an SNRI, we should avoid MDMA at all costs unless she comes off the medicine at some point? Has anybody rolled while being on Savella, just curious? Her Health is Waaaay more important than rolling to me. According to the Savella Pamphlet it seems like there are just so many side effects; hopefully she will not experience any of those. The only other things we partake in on occassion are smoke, Lucy, and shrooms. I have not found any info saying she can not take this antidepressant with Lucy or shrooms....but if anyone knows of this statement to be false please let me know...Safety First!!!! Any Helpful Feedback would be appreciated Thank You, Willow
Mmm, I know people who have rolled on a SNRI and have been perfectly fine (to my knowledge), but I don't know enough about it to tell you with absolute certainty that it is okay. Hopefully another member can shed a little more light onto this topic.
I've had some experiences taking substances while on SSRIs (different but somewhat similar to SNRIs) and I've also had some long-lasting bad effects, though whether they are from the SSRIs, or the other substances, or both, or neither, is a big question mark. I would at the very least wait some time (few months at the least) for your gf to make sure that she's doing well on the SNRI before trying anything serotonergic or otherwise heavy (shrooms, lucy, and rolling.) Just think - everything might be a okay, but if it wasn't at some point, you might not know what caused it - the SNRI? The other substance? The combination of the two? It's not really worth the risk, in my opinion, and based on the results my own experiences (which I still have to deal with daily.) The good news is, to the best of my knowledge, smoking (I assume you're talking about cigarettes or buds) shouldn't affect or be affected by the SNRI medication! Of course, I'm not a doctor, and I haven't read a whole lot about SNRIs myself, having been disillusioned after my experiences with SSRI, but generally cigarettes and bud stick to their own neural receptors, and leave serotonin and norepinephrine more or less alone
I am uncertain myself in regards to SSRI vs. SNRI but I go by the general rule that any antidepressant which effects serotonin should be avoided when taking MDMA or any other psychedelics for that matter. It very well may be that certain SNRI's are alright with psychedelics but I've seen first hand and heard many times on the net of people not rolling because of their medication. Better to abstain for a few days prior to the medication if possible and guarantee a successful roll (assuming you know the drug is clean) than wasting a roll because of the medication.
If you take abstaining from the medication as the route (which is the safest route), generally (with MAOIs and SSRIs, not sure about SNRIs) you have to give it ~ 2 weeks before the drug no longer has any effect on the body.
I see, I didn't look up the half life, but if that is the case, your right, a few days would be fine. If you happen to know, do all SNRIs have a short half life? Because I know for SSRIs and MAOIs, you need to wait quite some time for the effects of the drug to wear off.
Any links on that because to my understanding, if MDMA had any MAOI activity, it would have a duration longer than the 3-4 hours that I experience. I know that if you mix a dosed natural MAOI you can make your roll much longer (syrian rue is the one I've been looking into) and undosed pharmaceuticals result in a never-ending roll (of doom) , so IDK. But if you have any link regarding MDMA having MAOI activity I would be very interested.
Im on a iPod right now which can't link, but I can look into it further when I get on a computer if I remember.
TY for the replies. She needs to be on the medication for a full 3 months before knowing if it will truly help her or not. So basically we will abstain for just a little while and see if the medicine helps her significantly. So what you are saying is the medicine has a short half life (8hours I believe) you said. So if she stopped taking it a couple days prior to the roll or trip she would be able to partake in said activities safely and to its fullest. Is it safe for her to come off of her meciation for just a couple days? And I assume after the roll or trip is done she would them resume her normal amount of meds the following days?
She may experience some withdrawal symptoms coming off the medication but I think it will be 'safe' to not take it for a few days. MDMA is essentially like a super anti-depressant anyways.
True until you come down lol and thats where the medication will kick back in. I read that Lucy and Shrooms are alot safer with antidepressants on a whole (depending on the antidepressant of course) but still very little info i found specifically to "SNri." Any insight into that? Would the same rules apply as far stopping the meds a couple/few days prior or do u think with other psychedelics thats not as necessary as it is with MDMA?
Oh and what kind of withdrawal symptoms? I would never want her to go through what i went through with my precscribed clonazepam that was the worst experience of my life!!! UGH.
I don't really have much more info than I supplied. The only other thing I can respond to in regards to your last 2 posts is that sometimes people have no comedown off MDMA really and even a positive afterglow lasting days to weeks after the experience but I wouldnt count on it. Remember alot of people take MDMA and dance all night which naturally will take alot out of you so often its the activities associated with mdma that are just as responsible for the negative back end. I am one of the unlucky ones who pretty much has mild depression from MDMA 2 days following the experience regardless of what I'm doing but some say they have never had a bad comedown.
Check out ' maoi's' on wikipedia and its under the list section. Not the best source but that's where I think I saw it.
Oh, it just says that they may have activity in high doses, which would make sense I guess because really high doses of MDMA = hallucinations. And MDMA + MAOI = hallucinations. But I don't think it has any activity (or any activity worth noting) in normal doses ~100 mgs.
Well I appreciate your Help! If anyone else has personal experiences with SNri's, I am open to hearing all experiences/suggesstions. I don't club and dance all night on MDMA here either. I find it much more eh hem entertaining and comfortable at home ;0
