I've noticed a couple times that after taking 2c-c, my tolerance to caffeine goes way up. This makes sense since both are stimulants and probably work on similar receptors in the brain. But what I want to know, and hopeful others with experience can shed some light on this, is whether it works the other way around - that is, does becoming tolerant to caffeine affect the potency of 2c-c (or any other 2c)? In other words, if I want to trip on a 2c this weekend, would it be best to abstain from caffeine until then? I try to abstain from caffeine generally and so the last two times trying 2c-c weren't good tests of this, but I will give myself caffeine days (usually Friday). But if I plan to trip on a 2c on Saturday, would my tolerance be shot by consuming caffeine on Friday?
Well I drink caffeine often, I probably have 400-500mg a day. I think that's a lot haha, but I don't know for sure. And I've only done 2-ce, but I don't feel like caffeine has affected my experience with it, even though I can't know for sure because I don't make a point to abstain from it before a trip. In fact, when I trip on any psychedelic, I like drinking a strong cup of coffee or a Spike energy drink(350mg of caffeine) when coming up. The other night, I drank a strong cup of coffee 2 hours after dosing and not feeling anything, and as I did so I felt like the levees were smashed and the 2-ce began flooding my brain with profound intensity. So I don't think it's necessary to abstain from caffeine, if there is some sort of tolerance issue concerning the two, I don't think it's very discernible.
I take caffeine daily and have used the 2c drugs a few times as well as other drugs. Like food I abstain from caffeiene at least a few hours before tripping, and try to not take any the whole day. I have drank some caffeiene early in the morning and tripped on 2cs later in the evening with no drop off in effects. However I have taken caffeiene right before MDMA and didn't notice a drop off in effects necessarily, but noticed increased body load and nausea.(caffeiene is actually a common ecstasy adulterant) Caffeiene's primary effect on the brain is different than the 2c's primary effect on the brain but i think it would probably be similar to MDMA and just increse negative physical effects and not add anything to the experience. My advice is don't take any caffeine the same day as tripping on 2cs.
Thanks all. Seems like the general consensus is that caffeine tolerance won't affect 2c tolerance. Any insights into whether (and why) it might work the other way around - because, though it's only been a couple times, both are consistent: the day after taking 2c-c, caffeine had little affect on me (and this is after abstaining from caffeine for about a week).
Most of my caffeine consumption comes from soda, so it's not something that's I have ever really thought about or noticed to much since soda to me tastes delightful even without a mild caffeine buzz.
