Oxycodone - repetitive dosing doesn't seem to work - why?

In my experience ..

If you dose oxycodone to the point where you get a buzz, and then try to dose again like 1-2 hours later, you won't feel the second dose. What is this about? The receptors are no longer available for some reason? How long does it take to be able to take another effective dose? 4+ hours maybe?

Thanks all.

-dd

 

I know what you're saying. With me, sometimes the buzz increases, and sometimes it just sedates me more. I would like to say that it's a matter of dosage and timing, but there doesn't seem to be any rhyme or reason to it, at least for me. Opiate action in the brain is fairly complicated. I haven't done a lot of research on the internet, but what I've read seems to indicate that opiates bind to receptors that affect the release of Endorphins and Dopamine. They are involved in the euphoria you experience, and when they're depleted, it takes time for them to be replenished, and re-dosing beyond a certain point is just a waste of time. But like I say, that's just something I read from a little internet surfing on the subject.

 

Sounds about right. When i was in my Perc poppin days this happened all the time. I would end up eating 4 more, 4 more, but wouldnt get any more stoned. I soon realized all i was doing was wasting my pills.

 

I think taking all of your dose at once is better than spreading it out. 40mg at once is infinetly better than 20mg and another 20mg an hour later.

I find i can only achieve an extreme level of euphoria once per day from oxy. what im trying to say is, the rush is never as good as the first one of the day. Even if i take more than i did originally, i find the first dose of the day is significantly better than any redose.

If you wait to come down to redose it doesnt have much of an effect except increasing the sedation. However, if have noticed that if i redose during the peak it will prolong it. the problem is you cant let yourself go down for a second otherwise its a waste to redose.

here is my solution:
sniff 10mg every 5 minutes untill i run out of oxy. this allows me to continuously build the oxy high/euphoria without any chance of coming down and ruining the experience. You come up slightly slower than if you took all your dose at once but the peak is the same.

You gotta build that shit up or do your dose all at once. If you did mushrooms/mdma/acid twice in one day would you expect the second trip to be as good as the first...? No

 

The slow build-up makes more sense than doing it all at once. That seems like it might make you impatient, but the experience will last longer. I think I'll give that a try, taking one at a time at 30 min intervals. If I took the whole days dose at once, I'd just be drooling at the computer.

 

I am assuming you are taking the coating off before ingesting, but dnorting it is a much better high and you can save dope that way. When I was taking OC's this never happened to me, every inch of line i snorted increased my buzz. I stopped taking them because they became too expensive. I am not sure how many MGs urs are but I used to snort about 100-120mgs a day. Prices skyrocketed for some reason in my neck of the woods, from $35/80mg to $80/80mg which killed the trade all together, now they are allmost non-existing.

 

The problem with slow dosing is you miss the rush- which many of us strive for.