My laboratory at a local university has been interested in experimenting with RC's but only has limited experience with psychedelics. In my own scientific experience, I have researched salvia plenty of times (not my thing) and experimented with psychedelic mushrooms twice last month. Looking to experiment further with something similar, one of my chemists synthesized 4-AcO-DMT and recommended I do tests on it, with the belief it would have similar results as the psilocybin mushrooms. What do you think? With lack of experience would you recommend 4-AcO-DMT?
it would have similar effects as psilocybin mushrooms. I think what happens is your body metabolises the 4-Aco-DMT directly into psylocin. So it should have virtually the same effects as shrooms.
yeah that seems to be my understanding as well. plus from what I have heard, rats have responded with a gentler and slightly more euphoric onset than they do with psilocybin mushrooms. I know it is dependent on several factors but how do you feel 25mg of 4-AcO-DMT would compare to 3 grams of psilocybin mushrooms? stronger? weaker? about the same? I ask this because our lab lacks a miligram scale and theoretically since our recipe synthesized 50mg, separating it half and half would be 25 mg. is 25 mg a good first time dose? Also, where can miligram scales be purchased?
Psilacetin deacetylates (I believe somewhat slowly so that's why it's gradual) into 4-HO-DMT (psilocin). Psilocybin is rapidly dephosphorylated in the body to psilocin. That's where the difference is in come-up between shrooms and 4-AcO-DMT. So what you end up with after 4-AcO-DMT is I believe 90% Psilocin, "which acts as a 5HT2A, 5HT2C and 5HT1A agonist. Psilocin is structurally similar to serotonin (5-HT)[5], differing only by the hydroxyl group being on the 4-position rather than the 5 and the dimethyl groups on the nitrogen. Its effects are thought to come from its ability to mimic serotonin at 5-HT2A serotonin receptors in the brain.' "Psilocin has no significant effect on dopamine receptors (unlike LSD) and only affects the noradrenergic system at very high dosage." http://www.dealextreme.com/details.dx/sku.10515 $23 scale, works great enough for me! Chinsy Chinese shit but it gets the job done.
i don't know anything about the water soulubility, but 25mg of 4-aco-dmt would probably be equivlent to 3g of shrooms. Erowid lists that as a strong dose.
The effects are different. There is not just psilocybin in the mushrooms. Shrooms are better than 4 aco dmt.
Yeah they have baeocytin or however the fuck you spell it. Keep in mind shrooms give you much more nausea. One interesting thought: if a psychedelic chemist was to synthesize PURE baoecytin and take that. Ehhh?
but Baeocystin and Norbaeocystin don't really effect the trip all too much. I think they are responsible for the propioception distortion but I could be wrong. I've just noticed that strains with higher Baoecystin content have a more alcohol-like onset.
high dose mushrooms have given me some nausea...i have friends who can't even keep down an eigth of P. cub's.
Yes, different people are more often than not going to experience symptoms such as nausea but it varies from person to person due to stomach contents many other factors. It has as much to do with the individual as the mushrooom.
shrooms may be better, but that doesn't change that the trips should be quite similar. even with all the extras in shrooms, that is still going to result in a similar trip as 4-aco-dmt
