Long lasting anxiety/depression - the best/worst RCs?

My algae reports having always been depressed and anxious. After a recent experiment of high dose 4-aco-dmt, the anxiety got worse making the depression a bit worse.

Are there any RCs that would treat this in the long term (post-dose), or in the short term (maintenence, daily dose)?

I'm interested in bk-MDMA and bk-MBDB or super low doses of a tryptamine or something.

Has anyone had any successes in this area? SSRIs etc never worked for depression, and the only thing that helps with the anxiety is benzos, but that leaves a little bit of depression.





I am fully aware that one answer is: no, drugs are bad, you need to be in a perfect mental health before partaking...

But the people in South America use Ayahuasca for healing... is that because of set/setting?

Any ideas would be appreciated, I am most interested in something that has a long term effect. I have heard that DMT can be a long term depression cure. I wonder if there is something similar for anxiety, or if it is a hoax.





Everyone should know by now that my interest in RCs is purely medical, and in the cases it is not, I need to know the medical long term effects.

 

You are not going to have very much luck finding the medical long term effects of research chemicals. Especially the brand brand brand new ones, they have literally no research done on them and have been used in limited amounts.

DMT isn't really a research chemical it has been used for over a thousand years I am pretty sure, and has a fairly large amount of research on it. I think you will be ok to use DMT even with depression or anxiety, although its probably not suggested.

 

I'm not sure you're going to find what you're looking for in RCs, but I should have some methylone (bk-MDMA) here pretty soon so I'll tell you how it is.

 

it's equally or more likely that RCs are gonna make your depression and anxiety worse. sorry man

get outside. do stuff that you enjoy.

 

Very interesting thread, my man. You and I, we think a lot a like.

I've contemplated low dose M1, AMT, M4, 5-meo-amt etc.

Binary Shadow is obviously right in that this is pretty much unknown territory. HOWEVER, believe it or not, AMT (also known at IT-290) was used extensively in Russia as an antidepressant. Don't remember all the details, but I'll have to look into it.

I have a little knowledge in this kind of thing (really only a little lol) and would be happy to help if I can. What all kind of things have you tried?

FWIW I've run through the gamut myself of SSRI's etc etc The next pharm I'll be trying is Agomelatine. (relatively new drug that works through melatonin receptors....very cool lol)

Cheers,
James

 

I would agree in that the potential is there. After smoking 5-meo-dmt, AFOAF had greatly increased anxiety for WEEKS afterwards.

Though that particular RC is infamous for having "trainwreck potential."

 

AMT is another one i thought was really fuckin intense. either that or just NOT fun, like diarrhea and cramping

you guys don't have to say "a friend"

 

2C_E always made me feel snazzy

 

That's strange, at what kind of dose did you experience these sides?

My good man, Jeebs, had exactly the opposite experience in that he thought it was lots of fun, found it to be physically benign* and relatively mellow...even with stupid dosing.

FWIW I'm sure the doses used for depression were very small and much lower than a recreational dose.

*aside from the initial purging of course

Edit: The doses for "Indopan" were 5-10mg's

 

I'm not sure what would and would not work. Most psychedelics work via 5ht agonism, I'm curious how effective "Indopan" was, and through what mechanism it's efficacy, if any, came from. Possibilities are MAO inhibiting properties (seem to be fairly mild), reuptake inhibition, and agonism at the 5ht receptors.

As I understand it, the leading theory on depression(also anxiety etc) that's out currently is that it's not so much a matter of neurotransmitter imbalances (though that makes for good marketing, Zoloft anyone?) but rather atrophy of neurons in certain parts of the brain. SSRI's, although not always effective, are supposed to work as such:

The increase in serotonin causes a downstream increase in BDNF (Brain derived neurotrophic factor) a nerve growth factor, which in turn causes neurogenesis and,....hopefully, alleviation of one's symptoms. The effects of which can be long lasting.

Whether or not any RC's can have a downstream effect on BDNF I do not know. Regardless of whether or not they can it doesn't mean too much, as there is still obviously a lot more to the picture as we're now making drugs that alleviate depression/anxiety via melatonin receptors....so who knows lol

As a side note I think I'm going to hit up Pubmed and see if there are any clinical studies on Indopan. If there are, they'd probably be in Russian lol

 

I believe DMT brought me out of 7 months of depression/anxiety...one hit of a spliff and Id be pacing around or playing counterstrike or something to keep my anxiety low as possible...after a dmt trip that was very plant/weed oriented i decided to give myself another shot at weed (smoked everyday for a year, had a concussuion, had major anxiety and depression which caused panic attacks even if I was in a room with a bunch of burning pot) and have been smoking since... I say go for it if you have some DMT, its relatively easy to extract just requires a full weekend and 5-7 hours of your time.

 

i should have been more clear

i thought AMT was that way from reading about it only
i've never tried it, so obviously my opinion doesn't count as much
and i could be thinking about 5-meo-amt

 

Have you read about ketamine therapy?

it's not so much a cure, as a bandaid [in the same way of an ssri or benzo]...though ketamine isn't a research chemical.



ketamine therapy is one thing, but isolated ketamine experiences have helped me work a few things out. [higher dose K-holes].

 

2C-E i'm tellin ya. Seems like it's my spiritual replenisher. Given the right mindset it can help you overcome anything.

Anxiety is tricky business, but it's not impossible to overcome. What does anxiety consist of besides needless worrying anyway?

 

A few decades ago, AMT was prescribed in low doses in europe as an anti-depressant, or so I've heard.

 

Ditto

 

http://en.wikipedia.org/wiki/Ketamine#Experimental_antidepressant_use

there's a link...

 

PINEAL POWER!!!!!

Peganum Harmala seeds....but you must have a good diet.

Better to do your research on RIMA's and MAOI's.

 

AMT:
α-Methyl-tryptamine, also known as alpha-methyltryptamine, α-MT, AMT or IT-290, is a synthetic drug of the tryptamine family. First developed as an antidepressant, in the 1960s it was produced commercially for this purpose in the Soviet Union under the trade name "Indopan" in 5mg and 10mg pills

 

Very interesting, thanks for the leads!

Anxiety is getting a little better, but I'm on Clonopin and shit and that's temprorary...

DMT/AMT sounds interesting. I will have to find DMT soon.



Was I correct in understanding that someone smoked weed for awhile and then it caused anxiety but then DMT was used and then weed could be smoked again since the anxiety wasn't as much?