You can try Piracetam, I tried it and it potentiates every drug i tried, with no side effects on its own. even made me more awake and here when i was on it daily for short while to test it. another thing is to engage in some physical activity, so if youre clubbing thats good, if not go for a loooong walk with music, or have sex, or whatever. that will cause even more lovely neurotransmitters to flood your synapses. cannabis helps mdma for some people, for others it KILLS the roll. see which one you are. and thats really it. oh yeah, and you can take more if you want. how much do you dose on average in mg?
Have a hot girl give you an amazing massage with lotion. Wash your hair with dandruff shampoo. It has menthol in it. Smoke a menthol cigarette. Use a vicks inhaler. Dance. Dance with glowsticks. Have someone give you a lightshow. Take a bubble bath, or a hot shower. (Don't stay in too long, and make sure to bring water!) Squeeze ice cubes in your hands. Kiss someone. Kiss someone with a piece of ice in your mouth. Chew gum. Have a conversation with someone you love, and express your feelings.
Obviously, the simple activities listed above are always the best way to go, but since they've already been mentioned, here's how you could intensify effects from a chemical perspective: - Pre-load with 5-HTP (5-hydroxytryptophan, the precursor to 5-hydroxytryptamine, which is what the brain uses to produce serotonin); I've heard that taking up to a gram about 4 hours before rolling (100-200mg each hour up to the roll) can make the roll much more intense. Other people say that it does nothing for them, but either way, 5-HTP acts as a neuroprotectant against the damage caused by MDMA. Give it a try. - The more MDMA you take, the more intense your euphoria will be. However, the problem with taking a lot (aside from the brain damage it can cause, of course) is that at high doses, it loses its selectivity for 5HT1B and 5HT2A serotonin receptors (which are responsible for high energy, empathy, and euphoria) and starts targeting 5HT2C receptors as well. These receptors inhibit dopamine release, which can often outweigh the euphoric effect of the MDMA by causing sluggishness and sometimes even anxiety or apathy. So, the idea is to get the most out of your MDMA dose by suppressing the activation of 5HT2C receptors. This can be accomplished by taking 5HT2C antagonists before rolling. If you want to try this, find Valdoxan, since most of the other antagonists are also SSRI's (selective serotonin reuptake inhibitors), and therefore will greatly decrease the efficacy of MDMA (and that defeats the purpose, doesn't it?) Also keep in mind that the first sentence of this bullet is only true to a point; eventually, you deplete your serotonin, after which you won't be able to go any higher, regardless of how much you take. Some studies have shown that as little as 175mg is enough to completely deplete your serotonin. - In principle, since MDMA feels so good because of dopamine release, taking L-Dopa (what your brain uses to make dopamine) before rolling should increase its effects, since there'll be more dopamine to go around. I would steer clear of this method, however, since more dopamine = more oxidation of free radicals = more brain damage. Also, L-tyrosine, with which a lot of people pre-load, doesn't work. It's the precursor to L-Dopa (and is less expensive), so most people reason that it will help them build a surplus of dopamine. But, unlike L-Dopa, it's stored outside the synaptic cleft, and is not normally depleted, so pre-loading with it is like trying to fill a gas tank that's already full: it just overflows, and will only be excreted. - Lastly, taking antioxidants (Vitamin C, Vitamin E, Vitamin B, Vitamin A, Alpha Lipoic Acid, etc.) in between your rolls can reduce your tolerance to MDMA. This makes for a more intense roll the next time around. I hope this helps at least a bit; good luck! P.L.U.R.
I think Serotonin release is quite a bit more responsible for the "good feeling" of MDMA then Dopamine. Also, if you can find me some information to back this information, and the studies you referred to, that would be awesome. Not doubting you, I just would like to see where you are getting your information from. Info like 175mg is enough to COMPLETELY deplete Serotonin.
You're right; serotonin is indirectly responsible for the "good feeling" of MDMA. However, the "rush" that comes and goes throughout the roll occurs because the activation of 5-HT2A and 5-HT1B serotonin receptors causes a surplus of dopamine to be built up in the presynaptic channel (instead of uniformly circulating in and out and the channel, which is what normally happens when serotonin is being recycled rather than constantly pumped out of receptors), which is abruptly released once the channel is full. In this way, serotonin is a modulator of "good feelings" more than it is the cause of them. At least in terms of linearity, dopamine is the direct cause, but serotonin is definitely the head of the operation. From "Utopian Pharmacology," by David Pearce: "Convergent strands of evidence indicate that dopamine release is critical to the MDMA magic. Dopaminergic activity in the brain and motor behaviour may be crudely interpreted as under the inhibitory control of the serotonin system. Yet the multiple serotonin pathways play functionally different roles. According to one hypothesis, the extra serotonin released by MDMA stimulates 5-HT2A receptors located on inhibitory gamma-aminobutyric acid (GABA) striatonigral neurons. VTA dopaminergic neurons in the brain's reward centres are under continuous inhibition by GABA. Stimulation of the 5-HT2A receptors inhibits these GABA neurons, thereby allowing the disinhibition of dopamine biosynthesis. Post-E levels of dopamine in the mesolimbic reward circuitry are far higher than would be explained by MDMA's relatively weak additional release of dopamine via the uptake carrier." Here's some sources for my information (thanks for being concerned and interested enough to ask!): - From "Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan," by Sprague JE, Huang X, Kanthasamy A, Nichols DE, Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, Life Sci 1994; 55(15):1193-8: Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) induced serotonergic neurotoxicity as measured by [3H]-paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 5-HIAA levels were also indicative of the protective effects of TRP and 5-HTP. These results suggest that depletion of 5-HT stores is important for MDMA-induced neurotoxicity. - From "Utopian Pharmacology," by David Pearce: he release of serotonin following an MDMA-induced reversal of the reuptake pump results in a stimulation of the 5-HT1B receptors and, at higher doses, increasingly of the 5-HT2A receptors as well. Such receptor stimulation can trigger marked hyperactivity, especially in young MDMA users who rave. At lower doses, MDMA-induced locomotor activity is caused mainly by the released serotonin's preferential activation of the 5-HT1B receptor. This is because serotonin has a somewhat higher affinity for the 5-HT1 receptors than the 5-HT2 receptors. The greater flood of serotonin in the synapses triggered by higher doses of MDMA promotes locomotor activity via 5-HT2A receptor-mediated dopamine stimulation as well. To complicate matters, MDMA may itself bind, albeit weakly, to the 5-HT2A receptor. A further complicating factor is that MDMA-induced release of serotonin stimulates the 5-HT2C receptors. Activation of the 5-HT2C receptors serves to mask expression of MDMA-induced hyperactivity, sometimes evidently more effectively than others. The various subpopulations of 5-HT2C receptor located on GABAergic neurons in the ventral tegmental area and the substantia nigra tend to exert a tonic inhibitory influence over the mesolimbic dopamine system. Thus 5-HT2C receptors tonically inhibit dopamine release in the nucleus accumbens, mostly it seems in virtue of their constitutive activity i.e. entering the activated receptor state in the absence of an agonist. Other things being equal, activation of 5-HT2C receptors is anxiogenic, demotivating and generally unpleasant. Certainly the stimulant effects of MDMA are greatly enhanced following treatment with a 5-HT2C antagonist. Sustained antagonism of the 5-HT2C receptors might well we harnessed to intensify the hedonic properties of long-lasting E-like consciousness. Less speculatively, 5-HT2C antagonists such as agomelatine (Valdoxan) are under investigation as potential clinical antidepressants. - As for the serotonin depletion figure, I was pretty surprised to hear this too! From "Acute effects of 3,4-methylenedioxymethamphetamine on brain serotonin synthesis in the dog studied by positron emission tomography," by Nishisawa S, Mzengeza S, Diksic M, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Quebec, Canada, Neurochem Int 1999 Jan; 34(1):33-40: "175mg of MDMA (about 1-2 caps) is generally all that is needed to completely deplete all your serotonin." I don't know if I believe that this figure is comprehensive either, but the moral of the story is that the quality of your roll seems to depend not on how much MDMA you ingest, but how much serotonin is available for release by the MDMA molecule (which takes on the role of neurotransmitter transporter when it enters the synaptic channel). This also makes sense because of the last point about 5-HT2C receptors: at high doses, MDMA starts to target them instead of 5-HT1B and 5-HT2A (when it starts to run out of serotonin in the receptors that cause hyperactivity and euphoria, it's forced to move onto to those implicated in anxiety and decreased locomotion). - The archive with the studies on each particular vitamin I listed is down at the moment, but you can check out all the links at www.mdma.net under the subheading MDMA: neuroprotection. In fact, all of these articles and studies can be found at www.mdma.net (Fantastic site!) I hope that this is informative! P.L.U.R.
According to wiki's 5htp page (http://en.wikipedia.org/wiki/5-hydroxytryptophan): When combined with MAO inhibitors, MDMA, Methylone, or other serotoninergic drugs 5-HTP may cause acute serotonin syndrome
5htp mixed with MDMA can cause Serotonin Syndrome? Uh... What? That part of the Wiki says that a citation is needed. You would have to basically overdose on 5htp before it could cause Serotonin Syndrome when mixing it with MDMA..... That doesn't make sense at all to me. Can someone with knowledge please find some information about taking 5htp with MDMA (which is one of the best things you can pre-load with) causes Serotonin Syndrome? Also, please try and explain it yourself, instead of posting some ridiculously long study that is extremely difficult to decipher.
Sure thing, Feelings... Taking an excessive amount of 5-HTP can cause serotonin syndrome, whether mixed with MDMA or on its own. The former is more common, since MDMA inhibits the reuptake of serotonin from the body (and serotonin syndrome is characterized by an excess of serotonin in the peripheral circulatory system). This is more common amongst people who regularly take antidepressants or other SSRI's, MAOI's, blood pressure medications, or 5-HTP on a daily basis (in which case the level of serotonin production is generally heightened, sometimes to the point that reuptake synapses can't keep up, and peripheral levels become excessive). However, taken infrequently, and at the right dosage (1000 mg and under seems to be fine, outside of the attenuating circumstances mentioned above), 5-HTP can be very good for you, and absolutely does act as a neuroprotectant against MDMA. Remember that even too much water while rolling (or otherwise can cause hyponatremia; it's all about dosage! Paracelsus, who definitely knew his stuff, said that "the right dose differentiates a posion from a remedy." A couple studies on the subject: - "3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan," by Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, Eur J Pharmacol 1990 Mar 27;178(3):313-20 - "5-Hydroxytryptophan: a clinically-effective serotonin precursor," by Birdsall TC, 73541.2166@compuserve.com, Altern Med Rev 1998 Aug; 3(4):271-80 - "5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects," by Byerley WF, et al, J Clin Psychopharmacol, 1987;7:127–137.
How does one explain that for many people, preloading with 5htp actually spoils the roll? drags it out longer, yet less intense, peak is wishy washy not really there, no EXPLOSION, just a harder and harder come up until you realize that now youre coming down.
anytime i smoked some weed while i was rollin, it def intensified the high. like i'd get crazy fucked up. anytime i mix mdma+weed i trip the fuck out. i don't know why cause neither of them are hallucinogens. but whatever, i have a good time.
