DXM!! crazyiest night of my life! out of this world experience, MOST INTENSE by farr!

Discussion in 'Pharmaceuticals' started by hebrewnational00, Dec 4, 2008.

  1. pedaltopedal

    pedaltopedal Member

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    You're right... there is always self control. However, things can change after you try it the first time. I'm not saying you'll instantly be hooked, but its likely your attitude and self control towards the drug will change once you try it. It happens to people all the time who just want to "Try it only once to see what its like" and then before they know it they've fallen completely in love with the drug and get hooked.

    And your parents and DARE officer were lying when they said pot was dangerous and addicting. They weren't lying when they said that about meth, though. It's too bad they don't get there facts straight... otherwise it leads to these sorts of false conclusions about drugs. So sad.
     
  2. i0-techno

    i0-techno The Magnificent Dope

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    Yea really, I work with a meth head, he is ashamed to be real with me about that shit, you can see his teeth going, but he isn't so bad yet, but it has full and utter control over his doings, I have just never seen any good shit come from it, but this body here is not touching meth, you can do whatever you like Mr. Dot.
     
  3. MrDot

    MrDot Senior Member

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    I suppose some people just have a more addicting mind state, ever since I did DXM for the first time in a highh dose all I wanted to do is do DXM. I can see myself doing it every weekened, it probally wont happen but my mind sees it happening. I've become addicted to muscle relaxers before, can eat an anti depressant like its candy anymore, but when things got to the point where it hurt my body I said no more, and then there was NO MORE. lol I suppose some people just go to points of no return, tell your friend to look at pictures of meth mouth, should make him stop. ha.
     
  4. nickers224

    nickers224 Member

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    uh sorry this is a little off-thread but what do you guys suggest as a good first dose (in mgs) of gel capsules because im thinking about trying some either this weekend or next

    thanks in advance
     
  5. MrDot

    MrDot Senior Member

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    Uhm, about 300-400mgs, just drink a 4oz bottle of robitussin that has only DXM as active ingrediant, 1 4oz bottle will do alot for you.
     
  6. Stephæ

    Stephæ Member

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    You can't say that about the 4oz, Dot, unless you know how much he weighs. How much ya weigh, nickers?
     
  7. hebrewnational00

    hebrewnational00 Senior Member

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    if ur smokin weed with it i wouldnt do more than 250mg's for ur first time.... if the weed is really good than 200 mgs should do that trick. (assumin u weigh around 135lbs)
     
  8. Mr.Writer

    Mr.Writer Senior Member

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    200mg? He might not feel anything . . . 400 is good for first time. My first time was with 650 and it was one of the best drug experiences of my life.
     
  9. Stephæ

    Stephæ Member

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    I agree with mr writer. If you weigh more than 150 though then you should up it 50mg for every 10lbs.
     
  10. hebrewnational00

    hebrewnational00 Senior Member

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    i weigh about 145lbs and i took 280mg approx... and smoked REALLY good weed, and idk what i would have done if it was anymore intense... but go for it. im just talkin from my experience.
     
  11. StonerBill

    StonerBill Learn

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    I think some of you need to realise that cough syrup is a dense sludge of sugars, artificial sweeteners, thickener, and preservatives. its really unhealthy to include in your diet.

    as for dosages.. everyone is so different. i took 300 and had a mild buzz and 600 got me 'trippin' in whatever way you could call dxm.

    ps. i loved it! thumbs up.. except for the cough syrup bit. the high is really unique.. it would be good if dealers extracted it and sold it alongside K
     
  12. espfeelit

    espfeelit Banned

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    extraction is very possible. if i had me 3000 mg of extracted DXM, i would be very happy, although my liver wouldnt. i heard of people i know taking extracted DXM, they say the high isnt the same.
     
  13. MrDot

    MrDot Senior Member

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    Yeah, I considered doing this, buying alotta delsyum and extracting the DXM from it, just for the simple fact of, I'm tired of the cough syurp.
     
  14. espfeelit

    espfeelit Banned

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    yeah, not to mention the holes in the brain deal, doesnt sound too promising
     
  15. MrDot

    MrDot Senior Member

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    Holes in the brain? wtf lol
     
  16. espfeelit

    espfeelit Banned

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    yeah, it puts them there, as does your liver suffer.
     
  17. MrDot

    MrDot Senior Member

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    That is, if you mix it with a bunch of random shit. There is actually no true facts about what dxm alone will do to your system, personally I love it when a kid will chug a whole bottle of cough syurp with dxm and other deadly stuff combined, my buddy came over and started chugging nyquil, i laughed and let him.
     
  18. espfeelit

    espfeelit Banned

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    haha. true. acetometaphin, a deadly advocate of live damage
     
  19. MrDot

    MrDot Senior Member

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    Yeah, you can get alot of DXM only cough suppressants but no one actually knows the dangers of DXM completly, it's unchartered territory. Territory i'm willing to venture into!

    A question of mine is, if mixed with valiums and stuff is it possible to give you the itch? Idk, yesterday (after of weekened doing 8oz of DXM) I got itches really bad all over my body, the only thing I did was valium and DXM so I'm confused about this. Could be my body saying eat another valium though, when I do alot of muscle relaxers over a long amount of time my body breaks out into bad muscle spasms once I haven't had it. Obviously this is addiction beating the fuck outta my body.
     
  20. Hippie McRaver

    Hippie McRaver Senior Member

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    Running Head: SIDE EFFECTS OF DEXTROMETHORPHAN ABUSE

    Abstract:
    The aim of this study was to investigate dextromethorphan (DXM) abuse side effects. Subjects were 53 volunteers who had consumed DXM with a mean age of 23.4 years. The mean of side effects during first day was 12.49 and during the first week was 5.57. The causes of repeated DXM abuse were psychological dependency (46.5%), recreational abuse (32.6%). Neurological and psychological symptoms were the most common of side effects in DXM abusers. (PsycINFO Database Record (c) 2008 APA, all rights reserved)(from the journal abstract)

    Results:
    Forty-eight males and five females participated in this study. The mean age of subjects was 23.4 years (range: 20–28 years old, SD = 1.83). Nine subjects (18.9%) did not have a history of consuming DXM for any medical purpose and other subjects had used DXM for chronic cough and cold with physician's prescription.

    Twenty-nine subjects (54.7%) abused DXM more than 10 times and twenty-eight subjects (52.8%) had history of DXM abuse for more than 3 years. The mean of frequency of DXM abuse was 25.5 (range: 1–200, SD = 41.09) and the mean of first and last dosage of DXM abuse in our subjects was 336.3 (75–1125) and 623.5 (90–2700) mg, respectively. Fifty-one people (92.5%) reported history of other illicit drug without any addiction criteria (according to DSM-IV). The most common illicit substances which were abused by our subjects are listed in Table 1.
    Table 1.

    The most common illicit substances which were abused by our subjects
    Illicit substances Frequency (%)
    Alcohol 51 (96.2)
    Marijuana 47 (88.7)
    Sedatives 38 (71.7)
    LSD 36 (67.9)
    Morphine 29 (54.7)
    Ecstasy 28 (52.8)
    Cocaine 16 (30.2)
    Heroin 13 (24.5)
    Phencyclidine 11 (20.7)
    Special K (Ketamine) 11 (20.7)
    Others 13 (24.5)
    Full-size table

    View Within Article


    According to participants, 3.8% had history depression and anxiety in the last year which they did not receive any treatment. In this study, all subjects experienced minimally 3 adverse effects during the first day and 51 subjects experienced minimally 1 adverse effect during the first week. The mean of side effects during the first day was 12.49 (range: 3–28, SD = 5.71) and during the first week was 5.57 (range: 0–14, SD = 3.38). Table 2 shows the adverse effect of DXM and frequency of everyone during the first day and first week (1–7 days) after the last abusing dose of subjects. All of the subjects had 3 side effects at least, although no emergency care was needed in them.

    Table 2.

    Adverse effect of DXM reported by research subjects
    Autonomic side effects

    Sweating
    Tachycardia
    Fatigue
    Tachypnea
    Flushing
    Cool feeling
    Gastrointestinal side effects
    Nausea
    Vomiting
    Diarrhea
    Constipation
    Neurological side effects
    Dyskinesia
    Speech disorder
    Dizziness
    Mydriasis and photophobia
    Blurred vision
    Diplopia
    Imbalance
    Dysaphia
    Tremor
    Psychological side effects
    Euphoria
    Trance
    Apathy
    Laughing
    Tongue biting
    Auditory hallucination
    Visual hallucination
    Insomnia
    Nightmare
    Anhedonia
    Dysmnesia
    Hyper vigilance
    Attention deficit
    Learning impairment
    Flash back
    Panic disorder
    Hyperactivity and inclination to dance
    Sexual side effects
    Increased libido
    Decreased libido
    Inclination to make love 16
    Others
    Itching
    Fatigue
    Urticaria
    Myalgia
    Icterus
    Facial edema
    Reinforcement



    The causes of repeated DXM abuse were psychological dependency 46.5% (20 subjects), recreational abuse in 32.6% (14 subjects) and physiological dependency in 2.3% (one subject).
    4. Discussion

    Our purpose in this study was to assess adverse effect of DXM in young adult abusers. DXM is absorbed quickly from the gastrointestinal tract; (within 30 min) and its duration of effects is about 3–6 h (half-life of about 2–4 h) (Shaul, Wandell, & Robertson, 1977). So after DXM abuse, many side effects especially gastrointestinal adverse effect are seen during a few hours and it is more common than in the future days. Despite frequent consumption of DXM by our patients, they did not have to refer to emergency care at the time of abuse. It can be due to low half-life of DXM.

    Dextrophan acts as phencyclidine (PCP) in the brain and the toxic effects of PCP and DXM are similar together (Jahng et al., 2001, Sharp, 1997 and Wolfe & Caravati, 1995).

    In this study, there was no death and any adverse effect in patients that needed medical support, although there are some people who are at increased risk of side effects of DXM with its normal dosage like those who take it along with MAO inhibitors and serotonin reuptake inhibitor drug use or those with P450-2D6 enzyme polymorphism (Sharp, 1997).

    Euphoria, altered time perception, feeling of floating, visual disturbance, tactile, visual and auditory hallucination, disorientation and increased perceptual awareness are primary psychological symptoms that were identified by Krenzelok (1990), Miller and Gold (1991), Wolfe and Caravati (1995). In our study, hallucination and flash back prevalence were 50.9% and 52.8%, respectively and our subjects abused DXM for these reasons. Hallucination states that are seen in DXM abuse, is similar to LSD, PCP abusers and MDMA (Ecstasy) (Wolfe & Caravati, 1995 and Yoo et al., 1996).

    DXM is available in various combinations with other medications, and approachability of this drug in Iran is not controlled. For these reasons, DXM abuse is being increased every day.

    Jasinski (2000), Liu et al. (2003) and Zapata et al. (2003) showed DXM reduced withdrawal symptoms and attenuates the behavioral or toxic effects of cocaine by reduction in opiate substance requirements and it is one of the causes of DXM abuse in addicted people. It also prevents hyperthermia in amphetamine drug abusers such as Ecstasy (Farfel & Seiden, 1995).

    According to Jones, Gallagher, and McFalls (1988), drug abuse can be classified into two categories: licit and illicit psychoactive drugs. Also, there are five forms of abuse including: experimental use, social recreational use, circumstantial, intensified and compulsive use. Murray and Brewerton (1993) believed DXM is a nonaddictive licit drug that does not have physiological or psychological dependency, although produces a substance dependence syndrome. In this study, although 18 subjects had to abuse DXM again, it is probably abused in circumstantial or intensified forms and others abuse DXM recreationally. According to Momodou (1996), DXM is abused because it is more readily available, cheaper and more socially acceptable than other licit substances. It is not associated with any widely known effects and its physiopsychological implications are not fully established or known to the potential abuser population.

    Conclusion:
    Dextromethorphan abuse is a potential social problem in the future and availability of DXM over the counter to all age groups must be revised.


    References:

    Andaloro et al., 1998 V.J. Andaloro, D.T. Monaghan and T.H. Rosenquist, Dextromethorphan and other N-Methyl d-Asparate receptor antagonists are tratogenic in the avian embryo model, International Pediatrics Research Foundation 43 (1998) (1), pp. 1–7. View Record in Scopus | Cited By in Scopus (27)

    Bem & Peck, 1992 J.L. Bem and R. Peck, Dextromethorphan. An overview of safety issues, Drug-Safety 7 (1992) (3), pp. 190–199. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (117)

    Bidaga et al., 1997 A. Bidaga, P. Gianelli and P. Popik, Opiate withdrawal with dextromethorphan, American Journal of Psychiatry 9 (1997), pp. 413–425.

    Cranston & Yoast, 1999 J.W. Cranston and R. Yoast, Abuse of dextromethorphan, Archives of Family Medicine 8 (1999) (2), pp. 99–100. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (22)

    Darboe et al., 1996 M.N. Darboe, S.R. Keenan and T.K. Richards, The abuse of dextromethorphan-based cough syrup: A pilot study of the community of Waynesboro, Pennsylvania, Adolescence 31 (1996), pp. 633–644. View Record in Scopus | Cited By in Scopus (24)

    Farfel & Seiden, 1995 G.M. Farfel and L.S. Seiden, Role of hypothermia in the mechanism of protection against serotonergic toxicity: II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan, Journal of Pharmacology and Experimental Therapeutics 272 (1995) (2), pp. 868–875. View Record in Scopus | Cited By in Scopus (76)

    Jahng et al., 2001 J.W. Jahng, T.Y. Zhang, S. Lee and D.G. Kim, Effect of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rates, European Journal of Pharmacology 431 (2001), pp. 47–52. Article | PDF (180 K) | View Record in Scopus | Cited By in Scopus (6)

    Jasinski, 2000 D.R. Jasinski, Abuse potential of morphine/dextromethorphan combinations, Journal of Pain and Symptom Management 19 (2000) (1 Suppl.), pp. S26–S30.

    Jones et al., 1988 B.J. Jones, B.J. Gallagher and J.A. McFalls, Social problems: Issues, opinions and solutions, McGrawhill, New York (1988).

    Krenzelok, 1990 E.P. Krenzelok, Non-prescription cough medicine abuse, Clinical Toxicology Forum 2 (1990), p. 5.

    Liu et al., 2003 Y. Liu, L. Qin, G. Li, W. Zhang, L. An and B. Liu et al., Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation, Journal of Pharmacology and Experimental Therapeutics 305 (2003) (1), pp. 212–218. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (65)

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    Murray & Brewerton, 1993 S. Murray and T. Brewerton, Abuse of over-the-counter dextromethorphan by teenagers, Southern Medical Journal 86 (1993) (10), pp. 1151–1153. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (29)

    Roberge et al., 1999 R.J. Roberge, K.H. Hirani, P.L. Rowland, R. Brekeley and E.P. Krenzelok, Dextromethorphan and pseudoephedrine induced agitated psychosis and ataxia: Case report, Journal of Emergency Medicine 17 (1999) (2), pp. 285–288. Article | PDF (59 K) | View Record in Scopus | Cited By in Scopus (20)

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    Shaul et al., 1977 W.L. Shaul, M. Wandell and W.O. Robertson, Dextromethorphan toxicity: Reversal by naloxone, Pediatrics 59 (1977) (1), pp. 117–118. View Record in Scopus | Cited By in Scopus (11)

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    Yoo et al., 1996 Y. Yoo, H. Chung, E. Kim and M. Kim, Fatal zipeprol and dextromethorphan poisonings in Korea, Journal of Analytical Toxicology 20 (1996), pp. 155–158. View Record in Scopus | Cited By in Scopus (13)

    Zapata et al., 2003 A. Zapata, M. Gasior, D.B. Geter, F.C. Tortella, A.H. Newman and J.M. Witkin, Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan, Pharmacology, Biochemistry and Behavior 74 (2003) (2), pp. 313–323. Article | PDF (217 K) | View Record in Scopus | Cited By in Scopus (3)

    Ziaee et al., in press Ziaee, V., Akbari, H.E., Hoshmand, A., & Saman, K. (in press). Abuse of dextromethorphan: Review and a case report. International Journal of Pharmacology, 1(4) (in press).

    retrieved from PsychINFO, from EBSCO database found at UMass Dartmouth
     

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