i have been reading a little lately about apap consumption...the figures i have seen mentioned as safe were in the range of 3 - 4 grams per day. then i remember during a hospital stay long ago, i was given percocets 2 at a time, each 4 hours, round the clock for days. i believe that was the highest available dosage that can be prescribed. at 325mg apap per pill, 12 pills per day, thats nearly 4000mg per day, as prescribed. i certainly would not suggest taking those amounts, especially dailly, but im certain that most people could tolerate it, i have seen figures of 10 - 12 grams of apap as being fatal, or causing immediate liver damage, but i dont know how accurate they are.