GBL to NaGHB ->Yield

Discussion in 'Drug Chemistry' started by whatsupdoc, Dec 8, 2006.

  1. whatsupdoc

    whatsupdoc Member

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    The reaction between GBL and NaOh is equimolar and in theory should produce an equimolar amount of NaGhb. For example 3.25 M of NaOH reacted with 3.25 M of GBL should yield 3.25 M NaGhb (i.e., 410 grams).

    The reaction is certainly not 100 % efficient, but would any one know the approximate efficiency. A figure of 50% eficiency has been thrown around , so in the above example the yield would be 205 grams.

    Thanks, the above is merely a mathmatical/chemical exercise, not a synthesis question.
     
  2. polymer

    polymer Senior Member

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    synthesis reactions seldom give 100% yields.

    since this is a base catalyzed hydrolysis reaction, the pH will have to be closely monitored, to determine whether the reaction favors the products, or reactants. this dictates yield.
    too high of a pH, you'll need to add more reactant to push equilibrium towards the product side. so you see, yield depends on how well you can titrate (monitor the pH) in this reaction; play your cards right, and you can probably get better than 80% yield.

    oh, and don't use tap water for your sodium hydroxide solution; use distilled water instead. the calcium/chloride ions in tap water may leave you with extraneous salts, which may hurt your yield.
     
  3. whatsupdoc

    whatsupdoc Member

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    Thanks for the info polymer. In theory ,would a final pH of 7.8 be a target for an 80% yield?
     
  4. polymer

    polymer Senior Member

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    yezzir
     
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