Any better meds?

Discussion in 'Pharmaceuticals' started by steve77, Jun 8, 2006.

  1. steve77

    steve77 Member

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    Hello folks.....i am wondering if anyone knows what types of PRESCRIPTION drugs out there are similiar to the feeling of "E"....I know I am not gonna get the same feeling as that but is there anything similiar that will help elavate mood for several hours and basically make u happy!.....I have had depression for several years and nothing has worked thus far as far as antidepressants go....am currently on adderall but dont like the lethargic feeling and not being happy. its more like a calming effect....anyone have suggestions?
     
  2. thrice989

    thrice989 Member

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    I tell you to take Percocets, that contain oxycodone or oxycontin.

    Yet besides cannabis, I wouldnt mix opiates or other stimulants with Adderall. Sorry.
     
  3. thrice989

    thrice989 Member

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    Esctacy (MDMA), affects many parts of you're brain including nuroreceptors that control serotonin, you can naturaly boost low levels of serotonin with anti-depressents, and I've heard of a chemical called HPT-5?? or somthing that can help. Look into it. Talk to a doctor :)
     
  4. StonerBill

    StonerBill Learn

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    yeh what youre lookin for wont be found. anyway youll only fuck yourself up and plunge into teh depths of no return if you take a euphoric drug to counter depression
     
  5. Trippin' Billies

    Trippin' Billies Senior Member

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    NO! NO! NO!


    don't try and cure depression with opiates! it will almost cerainly lead to a serious addiction
     
  6. trippedelia

    trippedelia wow

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    yeah twas what i was thinkin' trippinbillies.. itd be pretty weird if you did opiates in that situation and came out without an addiction.
     
  7. astroneurologist

    astroneurologist Member

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    steve 77, what antidepressants have you tried?

    There are some medications that help improve mood and some that improve depressed social functioning/social anxiety. Medications that modulate the action of serotonergic transmission in the brain typically take several weeks to take affect. Amphetamines of course work immediately but can lead to burn out and make depression worse. What might be happening in these cases is that amphetamine is stimulating the release of serotonin but the cell body cannot synthesize enough. Thus Thrice 989's suggestion of 5HTP supplementation might be a good idea. If you are on and medication, especially ones that effect serotonin (e.g. amphetamines, SSRIs, tricyclics), supplement CAUTIOUSLY beginning with very small amounts as to avoid serotonin syndrome. Alternatively one could increase dietary amounts of the amino acid tryptophan. Getting consistant quality sleep, exercise, and food are very important. Talk therapy/counseling helps some.

    There are no prescription medications that will substitute for "E" but I will list a few medications that might be of interest.
    Adderall (amphetamine salts): Agonist of dopamine, NE, and 5HT. Stimulates release and blocks reuptake to some degree.
    Ritalin (methylphenidate): Similar to amphetamine, but more specific to blocking reuptake of dopamine.
    Prozac (fluoxetine) has the highest affinity for the 5HT2 receptor of any SSRIs. Effexor (venlafaxine) begins to work faster than most antidepressants, low potency, phenethylamine moiety.
    Cymbalta (duloxetine) is similar to Effexor but is more potent and has a higher norepinephrine:serotonin effect ratio.
    Paxil (paroxetine) thought to be best SSRI for social anxiety, methylendioxy ring.
     

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