A number of reports suggest that 2C-C combines well with both 2C-E and 2C-I, and that 2C-I and 2C-E can be a nice combo. Anyone tried other combinations? 2-ct-2 with anything else? Are there combinations that mitigate the body load associated with most of the 2Cs, or that "deepen" the experience? (It seems like 2C-C keeps a pretty low profile on its own but can act as a bit of a potentiator for other 2Cs, making them more "psychedelic" and a bit more tranquil.)
SWIFS has tried a 2ce/i combo 20/10 (both ways). Alot like 30mgs of the one which was 20. Beyond that I can't help much with 2c combos, but a 2c in combo with a 4ho is very nice, the visuals of the 2c with the "depth" of the tryptamine. 2ce/4homipt was amazing, 2ct2/4homipt was nice in that the durations matched better, but nausea was a problem, though not enough to spoil the experience.
^Really? Where 'dja get your information from, punk? (Sorry, couldn't resist the Beastie Boys quote. But really: can you point me in the direction of sources that confirm that, or is this just a rumor?)
^^I don't know where he got his info, but I've seen the same on bluelight from people who's posts I accept as fact.
I am guessing probably: J Med Chem. 2005 Apr 7;48(7):2407-19. Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. Gallardo-Godoy A, Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE. Department of Chemistry, Faculty of Sciences, Universidad de Chile, Casilla 653, Santiago, Chile. A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-alpha methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Several compounds showed potent and selective MAO-A inhibitory activity (IC(50) in the submicromolar range) but none showed appreciable activity toward MAO-B. A three-dimensional quantitative structure-activity relationship study for MAO-A inhibition was performed on the series using comparative molecular field analysis (CoMFA). The resulting model gave a cross-validated q(2) of 0.72 and showed that in this series of compounds steric properties of the substituents were more important than electrostatic effects. Molecular modeling based on the recently published crystal structure of inhibitor-bound MAO-A provided detailed evidence for specific interactions of the ligands with the enzyme, supported by previous references and consistent with results from the CoMFA. On the basis of these results, structural determinants for selectivity of substituted amphetamines for MAO-A are discussed. PMID: 15801832 [PubMed - indexed for MEDLINE] If memory serves, at least some of the 2C-T-x compounds would achieve significant activity in ‘common’ doses in man. I B
thanks I_B here is another: Monoamine Oxidase Inhibitory properties of some methoxylated and alkylthio amphetamine derivatives. Biochemical Pharmacology Vol. 54, pp1361-1369, 1997 Abstract The monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives with different substituents at or around the para position of the aromatic ring were evaluated. In in vitro studies in which a crude rat brain mitochondrial suspension was used as the source of MAO, several compounds showed a strong (IC50 in the submicromolar range), selective, reversible, time-independent, and concentration-related inhibition of MAO-A. After i.p. injection, the compounds induced an increase of serotonin and a decrease of 5-hydroxyindoleacetic acid in the raphe nuclei and hippocampus, confirming the in vitro results. The analysis of structure-activity relationships indicates that: molecules with amphetamine-like structure and different substitutions on the aromatic ring are potentially MAO-A inhibitors; substituents at different positions of the aromatic ring modify the potency but have little influence on the selectivity; substituents at the para position such as amino, alkoxyl, halogens, or alkylthio produce a significant increase in the activity; the para-substituent must be an electron donor; bulky groups next to the para substituent lead to a decrease in the activity; substituents located at positions more distant on the aromatic ring have less influence and, even when the substituent is a halogen (Cl, Br), an increase in the activity of the compound is obtained. Finally, the MAO-A inhibitory properties of some of the compounds evaluated are discussed in relation to: (a) potential antidepressant activity, and (b) their reported hallucinogenic, neurotoxic, or anxiolytic effects.
