if you're taking percocets or vicodin, how many mg of acetaminophen can the average human's body handle?
LD50 - The dose that has been determined to be lethal to 50% of the test population. Acetaminophen 338 mg/Kg o mice Kg = 2.2 pounds
that confused me. i'll just use an example: if i've got 5/500 percocets, is taking four of them at once going to be incredibly harmful to my body?
No that is no gonna harm your body, that amount is hardly anything, your fine. And what hippypaul meant by that post is that for every 2.2 pounds you have on your body it can handle 338mg, lets say if you weigh 140 then the lethal expected dose would be 21500mg, im sure even 10k would start to do SERIOUS damage to your liver to complete failure, you are fine with your dose. If you want to take alot more perc's then do CWE(cold water extraction) to extract the APAP.
all my doctors say that 4 grams or less of acetaminophen per day will not cause problems with liver toxicity. Therefore, if you were prescribed 10/325 norcos (hydrocodone and acetaminophen) you could take 12 and not have any problems. thats 120mg of hydrocodone, which is a shitload. the most i've taken is 90mg (i usually do 75mg). I hear of people who take 4 hc's and puke but these people tend to be skinny girls and i'm a big guy. theres two things important to point out. One, if you take more than 4 grams doesn't mean your going to have no more liver. I did 4-6 grams a day about 35 times until i learned about the cold water extraction. But i DO NOT recommend people doing this who live with their parents for obvious reasons (unless your parents let you get high) anyway, i took a blood test recently to check my liver and the results were fine, even after people told me my liver would explode. But And the second thing i need to say is that 75-90 mg hydrocodone (5-6 grams aceta - i was taking 7.5/500 lortab then) is nothing. If you search the "pharmaceuticals" forum (either that or the opiate forum), you will find a post started by the user "Mercury" about her husband who was taking 40 hydrocodones a day. Having norco is rare (most have vicodin or lortab) so i'm estimating he was taking 20 to 30 grams aceta per day (when maximum is 4). and he definately did it more than once. But if you are court ordered to AA/NA meetings, you will hear of people admitting that they took 56 hydrocodones a day (high tolerance) which is 28-42 grams a day.
Also when doctors say 4 grams or less per day, that means taking them through out the dose, not all at once, and 4 grams is fine on your liver but will make you sick sometimes, or well certain people.
100 percent right on - I should have went into more detail - thanks man The following from neonjoint.com might help also Below is an example of a codeine extraction. The idea behind the following extraction is that acetaminophen and aspirin (I'll use A/A from now on) are very _insoluble_ in cold water. Codeine phosphate (the most common salt of codeine) is very _soluble_ in water including cold water. The following table explains: Solubility (31C water) Solubility (21C water) Aspirin 1g / 100 ml 1g / 300ml Acetaminophen 1g / 70 ml 1g / 150 ml Codeine 1g / 2.3 ml 1g / 0.7 ml Phosphate So as you can see, both A/A aren't very soluble in 21C water, so if you cool the water to around 10C, the solubility will drop even further. That way you can dissolve 20 tablets in 50ml of hot water, cool the water down to 10C, filter the solution and end up with the same amount of codeine as the tablets contained but only a fraction of the original amount of A/A. [...] 1. Obtain a quantity of tablets containing codeine, check to see if they contain anything other than codeine, caffeine, acetaminophen or aspirin. If they do, and you don't know whether or not it will be a problem, your best bet is not to use them. Measure out your desired amount of codeine (ex. 64 mg = 8 tablets * 8mg/tablet). You may want to add 2 extra tablets as it is quite likely you will lose some codeine in the procedure. As you get more experience with the procedure you will be able to get approx. 95% of the codeine extracted. 2. Measure out some nice hot water, use approx. 40ml / 20 tablets or more if needed. I would suggest you don't go over 50ml for 20 tablets. I don't know if the use of boiling water would destroy any of the codeine but your best bet is not to use it. Use hot water but not boiling. Make sure the tablets dissolve completely. Some dissolve on contact with water while others need some help dissolving by crushing them. Note : not all of the tablet will dissolve, there are water-insoluble fillers in the tablet and not all of the A/A will dissolve either(which is what we want). 3. Place the solution in a cold bath, I just use some ice cubes in a container of water. Stir the mixture occasionally until the solution drops to about 15C or lower. You won't need a thermometer to measure the temperature, just make sure it's "cold". This will take about 30 min. If you wish to speed this up, you can use less water to dissolve the tablets, and add ice chips to cool the mixture faster. Just make sure you don't add so much ice that you drastically increase the volume of the mixture. 4. Filter the solution using whatever you have. Coffee filters work well, but lab filters work the best. Just make sure you don't end up with obvious solids in the filtered solution. This will take about 1 hr. You may also want to rinse the solids left over in the filter with some ice-water to extract any remaining codeine.
Don't forget, though, that the LD50, as previously stated, has already killed 50% of the people. It does not infer that you can safely take up to that amount.
I'm a liver patient, and I'll tell you- anyone who ingest more than 2 grams of acetomeniphen at once is a fool. Liver damage is not nice and nothing to fuck around with.
