Smoking shrooms update - MAO inhibitors

I heard this on a Terence Mckenna recording, and although i havent tried it it sounds very plausible, if one wants to smoke shrooms, you can do so by inhibiting your MAO beforehand. Take a dose of Syrian Rue (or Banisteriopsis caapi or any other MAO inhibitor and there are MANY) wait until it is in your system, then smoke the mushrooms and they should have a profound effect. I will get round to trying this one day and post back

 

It makes sense. But for all the trouble of having to watch carefully what you eat (while on MAOIs you have to avoid many common foods), you might as well just eat the mushrooms for effect. That's not to say that MAOIs aren't useful, but they're probably better spent on DMT-containing plants, for example, which require them.

 

if you had read the thread posted just a few below yours (smoking mushrooms--the definitive answer), you would not have made this post.

even smoking pure psilocybin/psilocin does nothing because it is destroyed by the heat. so why would altering the chemicals in your brain prior to smoking change this fact?

 

I did read the entire thread about smoking mushrooms and it was for that reason that i started this thread, it is indeed true that psilocybin decomposes at temperatures much above 100C. However taking an MAO inhibitor DOES NOT change the chemicals in your brain(at least not exclusively) it temporarily prevents your body from creating the chemical monoamine oxidase, it is this chemical that is responsible for the metabolization of psilocybin(and any indole alkaloid), therefore inhibiting its production means that when psilocybin enters your system, it is not metabolized as rapidly. When you smoke mushrooms, a tiny amount of undecomposed psilocybin is able to make it into your bloodstream, not enough to have an effect ordinarily but with MAO inhibition the effect can (according to Terence Mckenna - my source for this info) be felt.

 

possible bad idea.
I post on a much larger drug community, and unfortunately it costs $10 to have access to the forums, but they are very reliable. Heres an excerpt from a post about taking Mushrooms with an rX MAOI. I don't know what type of MAOI Syrian Rue is, but you can try researching yourself before....please.

I've recently come into an amount of mushrooms and I've been thinking about ways to enhance my trip(s) and get the most out of my doses. As I was thinking about it, I remembered that I still had an old perscription for Nardil, a perscription MAOI that I used to take to help curb my anxiety, laying around. Sure enough, I've got about a half of a tube left. Having read a good deal about MAOIs and their effects on the actions of foods and other drugs, it occured to me that perhaps I could use the Nardil to effectively "double" my doses, as the MAOI-mushroom folklore reads.

"I've got the MAOI diet down, having taken them several times a day for the better part of a year, until I quit them about nine months ago. I don't currently take any perscription meds and have taken psychedelics a handful of times before. I'm wondering if this is a good idea, and if so, what kind of Nardil dosage I should be considering. Does anyone have any experience mixing perscription MAOIs and psychedelics? I've read both positive and negative stories on the combination of passionflower or syrian rue with mushrooms but have yet to find anyone using pharmaceutical-grade MAOIs to potentiate the effects of mushrooms? Anyone? Holla back! Thanks."


"Nardil is Phenelzine, an irreversible monoamine oxidase inhibitor. That's not good.

Irreversible MAOIs bind permanently to the MAO enzymes and continue their MAOI effects for up to two weeks after cessation of ingestion.

If for some reason you still think you want to do this, you need to take 60-90mg a day for 5-10 days before you'll achieve a peak MAOI effect of ~85%.

I'm not entirely positive if I'm thinking about this right, but inhibiting MAO action by %85 means 15% effectiveness. This is just a stab in the dark, but I'd assume that means it'd take 6.66 times the normal period to eliminate the psilocybin from your body. That works out to about 40 hours.

Since you mentioned you had the diet down already, I won't harp on that. If this still sounds appealing to you, by all means be a guinea pig; I'm pretty sure it won't kill you. You'll probably go insane, though.

Short Version: Sounds like a massive mistake in the making."

 

But you only have to observe constant dietary restrictions for MAOIs if you are on a course of taking them. Taking Syrian Rue once for the purposes of smoking shrooms only means you have to go without tyramine containing foods for a few hours, and even then the harmaline's MAOI properties are nothing like those of the prescription MAOIs that doctors prescribe. I think even if you did break the restrictions when under the influence of Syrian Rue the most you would get is a severe headache, but breaking them when on a course of chemical MAOIs can kill.

 

Syrian Rue and Banisteriopsis Caapi are neither irreversible, they inhibit MAO for a few hours after which MAO production returns to normal - stick with nature

 

MAO inhibitors do change your brain chemicals. that's how they work. just because they INHIBIT monoamine oxidase, does not mean it does nothing to your brain chemistry. they wouldn't do anything if they did not affect the action of the chemicals in the brain. the brain works in generally two ways -- excitory (agonist) or inhibitory (antagonist) action. inhibitory is one of the ways in which your neurotransmitters can be affected, and it's how MAOI does its job.