Herion/coke there is no better combo out there hands down. speed balls are Straight up heaven ! watch out though they can also be hell !!!
If I remember correctly...alcohol for example..with acid or shrooms had zero affect until the trip wore off then you were trashed! prefer hallos to be all by themselves, they are enough on their own.
The Hunter S. Thompson: Mescaline, Pot, Whisky, Nitrous Oxide, tons of Energy Drinks, Sleep Deprivation, and a good party with crazy party people. There is a very specific order in which different substances are consumed, throughout a very long weekend, but I don't have time to write it up right now.
Oxycontin + Xanax + Weed....of course this combo is only for the "smart people" or "pre-meds".....stoopid fucks will kill themselfs on this combo so beware and BREATHE!
Morphine or Oxy with weed was always the best combo for me, I haven't smoked in awhile and opiates are hard to come by, so it's mostly been alcohol and nicotine (+ my 3 cup's of coffee every morning )