5-meo-dmt can be synthesized, but is also naturally occuring. http://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml
Qualitatively, 5-meo offers less visuals and more of a mindfuck. Quantitatively, 5-meo is something like 10x stronger. N,N is what most people are talking about when they just say DMT.