Unexpected Combo: 2C-E, 5-HTP

I'll need to recreate the experience to know for sure, but I was pleasantly suprised by this combo. I've done as much as 50mg of 2c-e as a single dose (not recommended for beginners), but this time I took far less (22-24mg) but had an experience 4-5 times stronger than all other 2c-e trips. The only other strong psychadelic I've used in the past was shrooms. This experience felt 'stronger' quantatively, though qualitatively incomparable.

T-1:00 Drank 3/4 beers
T-0:30 Smoked half an amanita cap (10+ bowls). Mildly euphoric, though this may have contributed to this experience, but I've mixed amanita+2c-e without these effects.
T+0:00 250mg 5-HTP (Basically serotonin as I understand it.)
T+0:30 22-24mg 2c-e
T+1:00 Becoming wicked tired 5-HTP must be starting to kick.
T+1:30 Getting visual alerts, tempted to just fall asleep. My friend and I decide to walk the block. During the walk I felt like I might collapse from extreme sleepiness.
T+1:45 Pop in beck dvd, only interesting when tripping heavely.
T+2:00 Begining to wake up. Buddy throws up all over himself, note to self by plastic buckets. I'm burping like a champ, and kindof wish I could throw up. Moderate body discomfort and nausea.
T+2:30 Tripping as hard as ever. Mild ego loss. Insane pulsating trails. Innability to focus. Extreme colors and moderate synathesia. Can feel the colors flowing through my face, keep tasting and smelling familiar and foreign smells. Mild time compression and extreme dilation; time dilation seems to reach 4x. Massive colorshifting, and visuals seem more fluid, detailed, and organic than usual. I seem to have reached plateau, but this plateau continues for 2 more hours.
T+3:00 Effects still insane. Listening to many CDs including NIN 'With Teeth', great tripping music so long as it doesn't get too intense.
T+3:30 Walk the block, then lay down on the drive way trying to make sense of the stars for about 45 minutes.
T+4:30 Starting to come back, eating a can of peaches was amazing. Finally start to soak in the CEVs, which are also extremely insane. The move fast, and there is little continuity. Takes a lot of effort to focus on them, but well worth it.
T+5:30 About half way down, buddy wants to sleep, so I head to my room and put on Downward Spiral.
T+630 Back to maybe 25%, catch the sunrise, insane gradients, very cool.
T+7:00 Pop on the Dream Factory, and clock out.

Something, and I highly suspect it was the 5-HTP, shot the 2c-e to a whole new level. A very solid +++, A+. The only thing that would have enhanced would've been a stronger element of euporia. (We were supposed to get half an ounce of MJ, but our guy wasn't able to make it.)

Can anyone confirm/deny/contest the efficacy of the 5-HTP in combo with 2-ce?

 

you shouldn't mix alcohol with any research chemicals.

but cool nevertheless, I actually have some 5-HTP lieing around my house, if i ever get my hands on some 2c-e, i'll be sure to try it out. I wonder if 5-HTP does that with any other psychedelics.

 

Not to be an idiot, but I hadn't heard about contraindications involving Alcohol and RC's. Though I don't remember specifically looking. Could you elaborate?


Yeah, I'm thinking any psychadelic that works on serotonin, might be effective having your serotonin levels 'charged' or loaded before hand 5-HTP. I haven't been able to find any specific reports involving any phens except 'pre-loading' for MDMA (and use for comedown/recovery).

 

5-htp isn't psychedelic in any amount that i've tried or heard of. I don't see how it could potientiate 2c-e by 4 or 5 times. Potientiation usually occurs when two similar drugs are taken or a drug that effects the metabolism of the other or something like that. 5-htp is a pretty common otc sup. and I never heard of any potientation with any other drug or chemical either directly or from med. books.

 

4-5 is probably a bit hyperbolic. Easily 2 fold potentiation though. We weren't expecting anything, and were totally suprised by this. So I'm absolutely certain it wasn't a placebo. Though the potentiating component needs to be nailed down. It was experienced by both me and my friend, but we consumed everything 1-to-1.

I know for a fact that 5-HTP has been used to 'preload' for MDMA which I understand 2c-e is chemically similar. (If anyone wants links I can find them again, Lyceam has an article or two on it.) MDMA is known to operate on the serotonin receptors, so it seems resonable that having more serotonin in stock in the brain will likely increase the effects should that be a neurotransmitter that the psychadelic works on. So maybe it's like super charging a battery with HTP, then when you flip the latch with 2c-e/X it there's more serotonin to play with. Seems plausible at least.

We will attempt a repeat this weekend, but this time leave out everything except HTP and 2ce, and I'll report back. Also, if anyone else is sitting on some 2c-e and would like to experiment, after a little research it seems that it's best to take the HTP-5 1-3 hours prior to the 2c-e. And spreading it out in multiple doses at 15-30 minute intervals might help keep you from getting two sleepy. Probably somewhere in the 200mg range would be good.

I can't speak for my friend, but I might also be typically difficient in Serotonin, and taking HTP maybe just put me where everyone else is. I suffer from chronic mild depression with a few cases of acute severe depression. But the fact that my buddy experinced extreme potention makes me believe this isn't the case.

Conclusion, further experimentation is need, and be careful if you're on any SSRIs (antidepresants: Zoloft, Paxil, etc)

 

Oh, and a quick word on availability. Wal-Mart caries 50mb caps, 45 count, for ~$8. So I'd assume you can get it at any chain pharmacy or 'natural' stroe.

 

I had always heard that taking 5-htp was usually done during the comedown of mdma, to help serotonin depletion caused by the mdma. http://www.erowid.org/ask/ask.cgi?ID=2355 here is a related erowid link.

 

Seems all reports of preloading effects are antecdotal at best. ( Such as mine. )

Here are the links on Lycaeum I mentioned:
'Phen Phun': http://leda.lycaeum.org/?ID=14565
'Preloading with 5-HTP': http://leda.lycaeum.org/?ID=6573

Perhaps the effectiveness of 5-HTP is closely related to personal chemistry. 2c-e itself seems to have very subjective user to user experiences to begin with. But for me, the combo provided the first +++ experience I've had on 2ce, and like I've mention I've taken twice as much (50mg), in fact, I did so less than a week before the above experience.

Thanks for the link.

 

AFAIK, 2C-E isn't serotonergic, so it's tough to see what effect preloading would have on a 2C-E experience. However, there are those anecdotal reports, so jury's out, I guess.

 

Banana do you have any evidence to support your claim that 2c-e is not serotonergic? Because I've been researching these novelty chemicals for the past 7 years and all my research has pointed in the direction of most phenethylamines and tryptamines being serotonergic. MDx chemicals are different in that they also effect the dopamine circuit.

Personally, I have never preloaded with 5-htp before 2ce, but I have with 2ci, LSD, and MDMA, and my experience has been this: 5-htp before a trip will add to the good time. LEt me take a step further and suggest that you keep on a regime of 5-htp, take it every night before bed, your overall mindstate is very likely to become better. It eases depression quite a bit.

When I first started experimenting with 5-htp I was shocked by the effect it had on me, I started urging family members and friends to try it. There was a very strong consensus that 5-htp has a very positive effect.

At one point in my life I was selling ecstasy and I became so convinced about the positive effect of 5-htp I started handing out 2 capsules with every pill.

In any case what it breaks down to is this: if it works for you, who cares why? Just go with it.
-MOR

Oh P.S. There is one contraindication about alcohol and 5-meo-dipt. Go through the foxy vault on erowid, and you will find more than one account mentioning a negative effect with the 5-meo-dipt and alcohol combination.

 

I actually started supplementing 5-HTP for my depression about three days now, and it's had a very positive overall effect. In fact, I heard that it's been more or less clinically proven to aid in depression. I heard about one case study where in 99 patients for whom SSRIs proved ineffective, had ~50 patients with marked gains on 5-HTP, but I don't think it was double blind. But the proof has been in the pudding for me.

I definitely found that 5-HTP added something very real to my 2c-e experience, and whether I can convince others to at least give it a try is of little consequence to me. It worked for me, and my friend, so in my world that's all the really maters.

 

Thats the spirit PooAtYou

 

5htp works for almostall psychdelics. it helps supplement your serotonin. eating healthy and taking vitamins also helps out with your trips.