Strange problem with oxycodone potentiation

Hi everyone. There's something that got me quite confused last night and I was hoping someone could help. Last night, SWIM decided to try potentiating their Oxycodone to heighten the effects. SWIM is always skeptical about things that seem too good to be true but decided to give it a shot anyway. SWIM followed the instructions found on this website, (http://www.hipforums.com/newforums/showthread.php?t=305596) however, a curious thing occurred in place of where the strong Oxy high was expected.

First let me backtrack and give you a bit of history. SWIM has chronic pancreatitis and takes Oxy for this but also likes to use in higher doses recreationally. Even with the chronic pain, SWIM doesn't have an extremely high tolerance. 30 or 40mg will do the trick every time. That said, I'll post a log of last night's attempt, kept by SWIM.

7/23/11 Empty Stomach
09:50pm - Took 400mg (2 pills) Tagamet with 8oz grapefruit juice and 8oz Tonic water

*EDIT* The grapefruit juice was white. It was 100% grapefruit juice and was from concentrate. Not sure if this all matters but some people seem to think so. *EDIT*

10:20pm - Took 25mg Diphenhydramine (1 pill), 30mg DXM (liquid) and 330mg Naproxen (1 & half pill)

10:30pm - Took 2 Tums

10:50pm - Took 30mg Oxycodone Immediate Release (6 pills x 5mg each, not cut with APAP)

Now, let me explained what happened. After taking the Oxy, SWIM waited and waited. At around the 30 minute mark, SWIM started getting a bad headache and a little nauseated. This continued to grow until about an hour and a half in, at which point, it plateaued and became rather annoying. The curious thing, however, was that at no point during the night was there even a hint of a buzz, let alone any kind of euphoria. 30mg of Oxy should have made SWIM pretty happy for at least 4 hours, regardless of whether the potentiators worked or not. Needless to say, SWIM is very confused. Does anyone have any ideas why this could have happened? Has this happened to anyone else trying to use potentiators?

Oh, and for the record, SWIM took another 30mg about an hour ago, without the use of potentiators, and is feeling mighty fine

Thanks, in advance, for any help or insight.

 

When i used to use oxy. I just sometime had some "off" days. Something to do with my chemical balance at the time or something was screwed up . Bc once in a blue moon i could just keep snorting and swallowing oc's and not feel anything. This might have happened to you...most likely just a coincedence (sorry about the spelling) i am sure if you gave it another shot you would be good. Or the potentiate actually worked and you just surpassed the level were you would normally feel euphoria and reached a spot where you just felt shitty. Those are my two guesses. ha.

Good luck next time

 

Grapefruit juice is known to cause migraine headaches for many people which would explain the headache and nausea. It would also explain not feeling high. The oxy was working to treat the migrain. Do you have a history of food induced migraines?

 

It could be a case of overkill. You mentioned 6 substances other than the Oxy, so there could have been some sort of interaction at play. What kind of interaction, I don't know. They are supposed to be opiod potentiators, though. I've had decent results with white grapefruit juice, though. But when I do it I drink a quart. Anyway, you could experiment with each one individually and gradually add others and weed out the culprit that way. But you said you got good results with Oxy just by itself, so you might want to just stick with that.

 

While I've also read many times that Grapefruit juice and Tagamet(antacids) would increase the affects of Oxy. Back when I was using, I experimented with a couple of recipes with no real enjoyable results. The one ingredient used to potentiate, a better word would be to add on to, that does work, and most all oxy users know that works is Xanax, of course, if done improperly, taking too much, can have some severe side affects up to and including your own funeral. I'm not spelling that out because I didn't think you knew but just in case someone reads this that doesn't know about the affects of a Combo of Opiates and Benzo's. That combo has probably killed more part-time recreational users that any other combo just for the simple fact that Xanax doesn't so much potentiate opiates but adds to it due to it's central nervous system depression. Knowing your limits on the amount of opiates you can safely handle is one thing, but when combining say Xanax, which has a habit of turning on your "I Don't give a Fuck" Switch, combined with I only took xxmgs about x minutes or hours ago, I THINK, is the REAL danger of adding Xanax to Opiates in my opinion. BTW, if you weren't aware, SWIM isn't required to be used here!

 

I often take diphenhydramine and/or other antihistamines when using opiates. Because they make you drowsy it can seem that the opiate is a bit stronger, especially at higher doses if your going for a nod. As for myself I take them to help with the itch that drives me crazy sometimes.
Low dose benzos can work as nice potentiators but like BottleFED stated it can be extremely dangerous and you should be very cautious with the dose.
Other than that I don't really use potentiators. Ive never used grapefruit juice and i had a really nasty experience with tagamet the couple times i tried it.
Unfortunately the main thing i use to enhance the high of opiates is...well...more opiates

 

Yeah, Xannies aren't to be trifled with. Sometimes I can go to sleep with 1/2 of a 0.5. That's 250 micrograms, lol.

 

Grapefruit juice counteracts many meds. If one is injecting oxy for effect, the best thing is an empty stomach, then wait about 15 minutes and then eat something solid. It pushes the medicine down into place of max absorption. I used to do this myself for years with any opiate pill that wasn't coated for time release. If it's contin, razor blade that crap off the outside. Nothing hits like a good opiate on an empty stomach with the food pushing it down about 15 after eating the med. Don't crush pills up. It just disperses them and some of it is neutralized by stomach acid. The only other thing I know that potentiates big time is a Lyrica or catpress. 'm not recommending mixing Lyrica and opiates. When I did them I slept so heavy I wet the bed for the first time in 50 years.

 

I crush mine up a lot. It hits like a bomb. However, due to an acid reflux problem I take a drug that reduces stomach acid. As for the grapefruit juice, it inhibits certain enzymes that results in higher blood levels of certain drugs, including Hydrocodone. Of course, the BA of Hydrocodone is >80% anyway, so the effect isn't really that dramatic.