is there any real reason why you couldn't mix EVERYTHING? not everything, but all your favorites, or anything you deem "ok". like do acid, mushrooms, ecstasy, opium, morning glories, mescaline, dmt, nutmeg, ayahuasca, kratom, salvia... basically everything you could think of, all at once? would you lower the doses down to each being a fraction so it altogether equals one dose of any given substance? how would you do it? what do you think would happen? would anything interact badly with anything else? anything else you'd add to the list? anything you'd take away?
There might be a point where there were so many chemicals in your body that you got really sick. But you would need to take a LOT of drugs at once for that to happen. I'm sure the high would be pretty scary. Salvia, dmt, shrooms and acid would be intense.
There are substances that one may be able to mix but this requires research. MDMA (in other words XTC that is only MDMA) has several substances it should not be mixed specifically that users currently do. Each substance a has dose threshold and to lower the dose each to accommodate several may defeat the purpose of the concoction. There is no reason why one couldn't mix them all; it's a matter of shouldn't. You would most likely be restricted to an oral dose, suppository, IV or IM injection.
I think combinations are more of a art of what to take to get to where a person needs to be, rather then just taking everything that a person can think of.
Well, the maoi in the ayahuasca, combined with other drugs such as amphetamines like xtc could be very dangerous or cause cause a person to die.