Question

icekila · Sep 25, 2011

HI, I have some questions, I have found a synthesis for hydrocodone/hydromorphone.

Dihydrocodeine + HCl + H3BO3 --->Dihydromorphine. Yes, simply refluxing dihydrocodeine in hydrochloric acid with a 5% boric acid rate-enhancer results in 95% dihydromorphine in 26 hours. DHM is 17% stronger than plain morphine & has a duration of about 6 hours (instead of about 4 for plain morphine). Dihydromorphine can be oxidised to hydromorphone (and DHC to hydrocodone) in several ways. Commercially it's usually done using chromic or aluminium isopropoxide (both unpleasant). I would be prepared to bet that the nice, non-toxic Dess–-Martin periodinane oxidation would work really well
Click to expand...

My question is what can I use to oxidize dihydrocodeine to hydrocodone? and dihydromorphine to oxidize to hydromorphone. A step by step with measurements will really appreciated. Thanks

icekila · Sep 27, 2011

Anyone?

Log in or Sign up

Question

icekila Member

icekila Member

Share This Page

Log in or Sign up

Question

icekila Member

icekila Member

Share This Page

Useful Searches