Hey I know plenty about oxycodone and its overdose symptoms, but what I don't know is WHEN it is safe to assume they're gone. My friend took a high dose of oxycodone over the course of about 4-5 hours. It's been over 1.5 hours since his last dose, and he's throwing up, but completely coherent on the phone. He knows to seek emergency attention if he feels like he's going to faint or he gets ridiculously confused. The half-life is 3-4.5 hours, so I'm wondering when one would consider him 80% safe from the chances of ODing. Would it be past the 3 hour mark, or would one normally OD directly after ingesting the oxy? I'm sorry is this thread seems loosely thrown together, because it is. I'm more just scared for my friend and making sure I do what I can to help him. He's a pretty big guy, and he has reported that his heart is not slowing down, but his vision will go blurry if he doesn't try to focus. His skin isn't cold or clammy to him. He reports being very drowsy, but he didn't exactly sleep at all last night. u4ia, kil0, does2, I'd definitely appreciate your responses.