Standard neo-Darwinian theory holds that most of the human genome must be junk or else there would be several lethal mutations per individual (they have apparently calculated the risk of spontaneously emerging dominant alleles with pre-reproductive age lethality). And yet the ENCODE project shows that most of the human genome is chemically active. There are attempts to explain it away by dismissing the bulk of that activity as "noise", but that away-explanation has several flaws: #The activity consumes energy. Moving the mobile reading proteins along the chromosomes, opening and closing the DNA spiral, actually making RNA... #There is plenty of "missing heredity", i.e. twin studies show lots of heredity but only a minor fraction of it can be accounted for by the part of the genome that neo-Darwinian theory considers to be functional. #Even if most of the human genome really was junk or protogenes, the fact that most of it is already translated into RNA makes it very easy for it to mutate into something coding for a lethal poison. This means that there is no way to explain away the mathematical inevitability of everybody having mutations, including dominant ones, that according to conventional medicine should be fatal. Obviously there must be some function-sensitive self-correction at play.