I'm just curious because there seems to be a flood of it coming through this one source of mine,and we share a mutual friend who's very versed in psychedelic chemistry..well just chemistry period,but most of his projects are psychedelic related..and i'm just curious if this mutual friend of ours could be producing it himself.
If you knew what you were doing you could easily take a legal 2c- and convert it to B. All that would require is a source. Making your own is not too far beyond that for the right person I am sure.
i feel like sourcing 2C-H or whatever precursor you'd need would be just about as hard as sourcing 2C-B
I'd steer clear if he was making it. Outside of a regulated commercial lab, the products you get could be mixed.
you would need a decent lab set up. distillation apparatus, probably a vacuum...things that most people don't have in their house.
So it's only H that would be of any use in this case? Because you can get many 2C's, but H is a rare one.
^^^actually i have no idea. shulgin's recipe doesn't start with any 2C-X, for some reason i thought it started with 2C-H
If you have to ask in a thread like this in a forum like this then it's far beyond your reach think 4 year chemistry degree, thousands of dollars of equipment, and years of practice. what kinds of "psychedelic related projects" does your friend do? if he's already making tryptamines and phenethylamines then 2c-b is right up his alley, but if he's just doing DMT extractions and stuff like that, that's like the difference between making a bowl of cereal and making an 8 course meal that would blow away every celebrity chef.
^^i would say that making LSD = the 8 course meal. making 2cb would be only be like 2 or 3 comparatively, but yes, it would be difficult without the things you mentioned.
2,5-dimethoxybenzaldehyde -> 2,5-dimethoxynitrostyrene -> 2,5-dimethoxyphenethylamine which is brominated to 2c-b. at least 24 hours of refluxing is required, you would need to be on some type of stimulant I would think when doing the cook in order to stay awake through the whole process
Huh? 2c-b requires a demonstrably easy synthesis. That synthesis itself is delineated, as you know, in PiHKaL and constitutes one of that book's shortest syntheses. That synthesis will be copied from PiHKal itself in toto and posted below: "A solution of 100 g of 2,5-dimethoxybenzaldehyde in 220 g nitromethane was treated with 10 g anhydrous ammonium acetate, and heated on a steam bath for 2.5 h with occasional swirling. The deep-red reaction mixture was stripped of the excess nitromethane under vacuum, and the residue crystallized spontaneously. This crude nitrostyrene was purified by grinding under IPA, filtering, and air-drying, to yield 85 g of 2,5-dimethoxy-beta-nitrostyrene as a yellow-orange product of adequate purity for the next step. Further purification can be achieved by recrystallization from boiling IPA. In a round-bottomed 2 L flask equipped with a magnetic stirrer and placed under an inert atmosphere, there was added 750 mL anhydrous THF, containing 30 g LAH. There was then added, in THF solution, 60 g 2,5-dimethoxy-beta-nitrostyrene. The final solution was a dirty yellow-brown color, and it was kept at reflux temperature for 24 h. After cooling, the excess hydride was destroyed by the dropwise addition of IPA. Then 30 mL 15% NaOH was added to convert the inorganic solids to a filterable mass. The reaction mixture was filtered and the filter cake washed first with THF and then with MeOH. The combined mother liquors and washings were freed of solvent under vacuum and the residue suspended in 1.5 L H2O. This was acidified with HCl, washed with with 3x100 mL CH2Cl2, made strongly basic with 25% NaOH, and reextracted with 4x100 mL CH2Cl2. The pooled extracts were stripped of solvent under vacuum, yielding 26 g of oily residue, which was distilled at 120-130 °C at 0.5 mm/Hg to give 21 g of a white oil, 2,5-dimethoxy-phenethylamine (2C-H) which picks up carbon dioxide from the air very quickly. To a well-stirred solution of 24.8 g 2,5-dimethoxyphenethylamine in 40 mL glacial acetic acid, there was added 22 g elemental bromine dissolved in 40 mL acetic acid. After a couple of min, there was the formation of solids and the simultaneous evolution of considerable heat. The reaction mixture was allowed to return to room temperature, filtered, and the solids washed sparingly with cold acetic acid. This was the hydrobromide salt. There are many complicated salt forms, both polymorphs and hydrates, that can make the isolation and characterization of 2C-B treacherous. The happiest route is to form the insoluble hydrochloride salt by way of the free base. The entire mass of acetic acid-wet salt was dissolved in warm H2O, made basic to at least pH 11 with 25% NaOH, and extracted with 3x100 mL CH2Cl2. Removal of the solvent gave 33.7 g of residue which was distilled at 115-130 °C at 0.4 mm/Hg. The white oil, 27.6 g, was dissolved in 50 mL H2O containing 7.0 g acetic acid. This clear solution was vigorous stirred, and treated with 20 mL concentrated HCl. There was an immediate formation of the anhydrous salt of 2,5-dimethoxy-4-bromophenethylamine hydrochloride (2C-B). This mass of crystals was removed by filtration (it can be loosened considerably by the addition of another 60 mL H2O), washed with a little H2O, and then with several 50 mL portions of Et2O. When completely air-dry, there was obtained 31.05 g of fine white needles, with a mp of 237-239 °C with decomposition. When there is too much H2O present at the time of adding the final concentrated HCl, a hydrated form of 2C-B is obtained. The hydrobromide salt melts at 214.5-215 °C. The acetate salt was reported to have a mp of 208-209 °C." Oh yea, and to the OP: On a numerical scale between 1 to 100 inclusive, with 1 corresponding to the easiest and 100 corresponding to the most difficult, 2c-b would be ~6 and something like 2-methoxymethyl Salvinorin B, or other Salvinorin A or even LSD analogues, would be ~100. It's in deed a compound that anyone could synthesize, insofar as they can acquire the correct information and the requisite chemicals and lab apparatuses.
Hey AceK, Are you familiar with this synthesis in practice? If you aren't, I'd advise you to please abstain from using psychoactives when doing this type of stuff. Psychostimulants and activities that require persistent assiduity (e.g., a chemical synthesis) and absolute patience don't mix well. But if you've done this before whilst stimulated, I suppose you know what you're doing and are a better person than I when it comes to stimulants and not acting rash and imprudent. If that's the case, I didn't mean to presume or condescend.
I guess I really shouldnt go and recommend that anyone go and attempt an inherently dangerous chemistry procedure involving refluxing of dangerous solvents such as nitromethane and the like while under the influence of anything but absolute sobriety and a clear head. I was just drawing attention to the fact that the synthesis requires a 24 hour reflux which should not be left unattended. I myself have not attempted this synthesis but the information is readily available. I have done other chemistry projects and a stimulant always helps me get through it but shakey hands and pouring solvents isn't the best combination. Most meth cooks cook on meth albeit with many accidents leading to prison sentences or possibly worse...I would say a PCP cook could not get away with the same, cooking while on PCP would be a disaster. Being sleep deprived at the end of a long process could lead to fuck ups too. Probably best would be to have a partner that would take over when the first cook became too fatigued.
