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Forum Description: Discuss other drugs psychedelic or not.
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Old 04-26-2005, 05:40 AM   #1
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dxm and wellbutrin
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Quote:
3.5 I'm Taking Other Drugs -- Can I Take DXM?


Quick answer: it depends. Don't take DXM if you are taking any of the following other drugs:


Antidepressants of any kind. MAOIs (monoamine oxidase inhibitors) are the worst; DXM + a MAOI will kill you. DXM with other antidepressants can cause serotonin syndrome, an unpleasant and occasionally fatal condition.
that's from http://www.dextroverse.org/faq/dxm_quickfaq.html#toc.3

I take Wellbutrin, an anti-depressant. I already know that being a depressed person can lead to bad trips on Psychedelic drugs, that's not my concern. I was wondering, would taking dxm while I'm on Wellbutrin lead to any damage, such as serotonin syndrome? I've done dxm once before, only enough for a 1st leve trip, while on Wellbutrin, and didn't have any negative effects.

Any answers would be appreciated.
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Old 04-26-2005, 05:43 AM   #2
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well, is your medication an maoi or a seratonin reuptake inhibitor or waht? ive never heard of wellbutrin and i can imagine a lot of other people havnt too
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Old 04-26-2005, 05:54 AM   #3
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well, I know it's not an MAOI, but I don't know about serotonin inhibitor...
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Old 04-26-2005, 06:03 AM   #4
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what does it say on the packet?
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Old 04-27-2005, 01:40 AM   #5
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Quote:
Originally Posted by StonerBill
what does it say on the packet?
This is most of the information on the package that seems at all important. BTW, it's a 300mg pill.:

Quote:
Each extended release tablet contains 300mg bupropion hydrochloride.
Quote:
Do not use in combination with Zyban or any other medicines that contain bupropion hydrochloride.
So basically, it's all bupropion hydrochloride, whatever that is...
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Old 04-27-2005, 03:55 AM   #6
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haha well i looked it up and the medication you are taking is still experimental, they dont know how it works.

to be safe, dont mix. the result of the mix would be unknown. the only way to know would be to try. so its a gamble.

since some of the sideaffects are the same as dxm (discomfort, itch, dry mouth, nausea/dizzyness) it would be best ot work up on doses slowly if your keen.

but its not an MAOI, and while it inhibits serotonin uptake to a certain extent, it is not very much.

personally i would not give my child the medication you are on.

but yeh it doesnt seem obviosuly a bad combination. but in higher doses this could be another issue.

why not try it, but do it somehwere relatively close to a hospital and with a tripsitter.
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Old 04-27-2005, 03:56 AM   #7
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can i ask waht condition would lead you to being prescribed this unusual drug?
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Old 04-27-2005, 04:45 AM   #8
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Wellbutrin is not experimental, and is not an unusual drug. The package insert probably says something along the lines of "the exact mechanism of bupropion hydrochloride is unknown". Almost every drug says that.

Wellbutrin increases levels of the neurotransmitter dopamine. While we may not know the exact mechanism of action, we do know that it does that. It is not an MAOI, nor is it an SSRI. It is a unique antidepressant. Wellbutrin and DXM in normal theraputic doses do not cause any clinically significant drug interactions. That being said, Wellbutrin lowers your seizure threshold, meaning you can have seizures easier. DXM can do the same thing. I would be concerned that you may be prone to a seizure if you take massive doses of DXM while on Wellbutrin. I can't tell you what the chance would be, because drug studies on humans are not conducted using such high doses for ethical reasons, but I would be concerned.
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Old 04-27-2005, 05:05 AM   #9
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seemed too wierd for me. and erowid said it did inhibi serotonin uptake, just not as much as conventionally classed SSRI's

but i wouldnt give my kid prozac either.

and it seems pretty unusual to me. reduce depression by increasing dopamine? that says something about the type of depression the person has doesnt it? meh id try anything before taking pharmaceutical psychoactives for actual medical purposes.

and i definately wouldnt let a doctor prescribe me something without telling me waht sort of drug it is. but thats just me. i read every ingredient list.
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Old 04-27-2005, 12:35 PM   #10
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Quote:
Originally Posted by StonerBill
and it seems pretty unusual to me. reduce depression by increasing dopamine? that says something about the type of depression the person has doesnt it?
Well, if it works, it tells you that a patient has depression that is responsive to dopamine. If it doesn't work, it tells you that a patients depression is not responsive to dopamine. I can't think of anything else it tells you. . .
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