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Forum Description: Discuss the technical details of the preparation of drugs
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Old 08-13-2007, 12:08 AM   #1
justsayno0
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how to hydrolize lisdexamfetamine in vyvanse
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lisdexamfetamine is made up of L-lysine and d-amphetamine. When takin the bodies amino acids break down and hydrolize the L-lysine from the d-amphetamine, slowly releasing the d-amphetamine so it can become active. My question is, is there a way to hydrolize lisdexamfetamine so you can activate the d-amphetamine before taking it? So you can turn the extended release into instant release and have the euphoric effect of adderall.
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Old 11-24-2007, 06:41 AM   #2
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my best guess for the time being /// charge the amino group with some acid (i don't know the pK right now) run on a CE column and elute with a gradient of methanol ----> methanol + diethanoloamine base solution.
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