Grapefruit juice

[bigmyke00]

Sorry if this has been asked before, but how well does grapefruit juice work and how much should i drink? Many thanks.:)

[Feelings Of U4ia]

For which drug? What is that you are exactly trying to do?

[jo_k_er_man]

maybe he's thirsty

[china_white]

or he just wants something bitter ;)

[Feelings Of U4ia]

I hate Grapefruit juce. Shit is disgusting.

[bigmyke00]

I hate grapefruit juice, but i was gonna drink some with oxy, i heard it makes it last longer and such.

[kil0]

what's the difference between GFJ and tagamet? I believe I read somewhere that they inhibit the same liver enzimes..

[china_white]

haha just have to chime in that i LVOEEEEE GF juice!

[TooCrisp]

I wouldn't expect much if any at all. It's probably just placebo effect, but may be worth a try. If in your mind you think its better, than I guess it really is better. But when you're talking about hard opiate drugs, fruit juice isn't gonna be the difference maker...

[IllCanabillyVanilly]

ive heard that if you drink grape fruit juice several hours before taking opiates it increases the effects. its pretty much been proven

[i0-techno]

It can't be from concentrate though, has to be 100% real fruit juice. Pomegranate juice, same thing. It works, just respect the fruit and intend on it working and it will. Maybe do it the day before and the day of to make sure it works.

[sam&ella]

Ruby Red grapefruit juice...it works.

[Feelings Of U4ia]

It can't be from concentrate though, has to be 100% real fruit juice. Pomegranate juice, same thing. It works, just respect the fruit and intend on it working and it will. Maybe do it the day before and the day of to make sure it works.

Info on Pom juice doing inhibiting the same enzyme as GFJ please?

[Eagles06]

On my Bottle and the paper that comes stapled to the bag of my xanax there are a few warnings about eating graipfruit and drinking grapfruit juice. Does this really increase the effects and if so how much should I take and how much does it really increase it? Is it just a little bit and they have to put it on there just in case or does it really do sumthing?

[C17H19NO3]

Just down a glass or two before you take em, while you're taking em, after, during, whatever. It's not like the more juice you drink, the more fucked up you get. An 8 oz glass beforehand will effectively inhibit the important enzymes (CYP3A4 and CYP2D6) for more than long enough for it to augment oxy, xanax, etc. You can try drinking more during and after to experiment. I've just drank it beforehand and noticed increased effects with xanax and halcion, haven't tried anything else yet. The reason this works is because these enzymes metabolize drugs by oxidation, which can be good or bad depending on what you're taking. Xanax (alprazolam), klonopin (clonazepam), and halcion (triazolam) are usually ones pharmacies issue warnings with since they are all metabolized by oxidation. Less drug metabolized = more in your system and for longer. These enzymes are still being researched and there is clinical evidence that the effects of THC, fentanyl, barbituates, DXM, amphetamine and other shit may be enhanced by drinking grapefruit juice and other Cytochrome P450 inhibitors. Quercetin is a very strong inhibitor (much stronger than fruit juice) of these enzymes that can be found in any grocery store's health foods aile ;)

[Feelings Of U4ia]

I've NEVER noticed a difference when taking this, or any other "potentiators" with opiates. Placebo probably is at work here. I understand it does inhibit that enzyme that helps break down certain drugs, but it doesn't work with every single drug/opiate.

Like I said, it didn't help me enough that I would ever consider drinking a nasty ass glass of GFJ again to try it.

Also, i0-techno, Pomegranate juice doesn't have the same effect as GFJ does. Not to mention if it did, there would be warnings on my meds about it, like there are about GFJ. If you have any proof to this, or if anyone does, please show me.

[BeanTwnJnky]

WELL i take quercitin 500 tablets from gnc and it does increase my high a little bit enough to were i keep buying these things it deffinitly works might depend on the person

[jo_k_er_man]

It can't be from concentrate though, has to be 100% real fruit juice. Pomegranate juice, same thing. It works, just respect the fruit and intend on it working and it will. Maybe do it the day before and the day of to make sure it works.

that sounds more like placebo than actually working.. if you hope and intend for something to work.. of course its gonna work... in your mind

[Feelings Of U4ia]

^Precisely my point.

[DcloudRnineO]

i don't believe this works. i drank a shitload of grapefruit juice before i took 5 norco 10's before, and it did less than it usually does. not realy sure what happened.

[junglejack]

ive been hearing this same story at my methadone clinic for years

[Feelings Of U4ia]

It's mainly just placebo. Most potentiators are, IMO. I mean it has been proven to inhibit a certain enzyme that helps to break down certain substances, which could cause a longer duration because it's taking a little longer to break the chemical down, but usually it's not enough to make a difference that you can really tell.

[i0-techno]

that sounds more like placebo than actually working.. if you hope and intend for something to work.. of course its gonna work... in your mind


Without intent nothing works, that is life, except it.

[jo_k_er_man]

Without intent nothing works, that is life, except it.


are you telling me if i dont intend to get high on OC and i snort 80mg.. im not gonna get high? or even better yet.. my intent is not to trip it is to stop a cold.. i drink 1/2 bottle of cough syrup and wake up 3hrs later with my walls breathing and everything bight as can be.. yea.. that happened sunday afternoon

[Feelings Of U4ia]

are you telling me if i dont intend to get high on OC and i snort 80mg.. im not gonna get high? or even better yet.. my intent is not to trip it is to stop a cold.. i drink 1/2 bottle of cough syrup and wake up 3hrs later with my walls breathing and everything bight as can be.. yea.. that happened sunday afternoon

Haha.

Placebo junkies are the worst, lol.

[i0-techno]

You would be amazed.