View Full Version : DXM!! crazyiest night of my life! out of this world experience, MOST INTENSE by farr!
hebrewnational00
12-04-2008, 04:31 PM
So last night me and my friend did 20 cough gels each! it was the most intense thing ive ever done in my life, ive done shrooms numerous times before and this is a lot more intense!!! seriouslyy! read up on my story...
downed the gels, then played fifa while waitin for it to kick in... slowly we started feelings really drunk so we wanted to wait until it has FULLY kicked in before we smoke some of this REALLY good weed we had, so thats wat we did, and then once it fully kicked in and we smoked like 2-3 bowl packs, we were seriously out of this world! like... if i took a hit of acid and last nights effects is what i got i would b like DAMN acid is soo intense!, if i got 2 extasy rolls and took em and last nights effects is what i got i would b like EX is the most intense drug ive ever done! ....thats how intense it was....
so we did 300mgs' each....we smoked weed, then walked around for a long time and it felt like we were floating, it felt like we were in a copletely new world, our open+ closed eye visuals were pretty strong, and our body high was insane! so we decided we should DOCUMENT all the crazy things we do from now on so we can look back at it when we are older, so we decided TO WALK to walmart and buy a camera at that second! it was like 1 a.m. and we have superwalmart like 3 miles away! so we walked there...and let me tell you! walmart at that time is the crazyiest thing EVER, too intesne too crazy!! we had to leave asap cuz it was wayyyy to intense!! we felt like we were overheating and our brains were going too wild! so we left and talked about how everything has been intense ALL night!
DXM has been SO crazy ever since it kicked in last night, ive done it twice before but never felt like i did last night~! ever....
do i recommend it? if ur going to do it once every LONG period of time like once-twice a year than YES i do recommend it. I HAD A BLASTTT!!
i defintily feel fried right now! :confused:
hehe
comment on this:cheers2:
peace
Stephζ
12-04-2008, 05:14 PM
Hell yea, sounds like you had an awesome time. Congrats :]
hebrewnational00
12-04-2008, 08:15 PM
lol i was still really messed up typing that ^^^ now im a little better but i still feel weired as hell!
i cant get over how crazy last night was! and what i love about tripping and thinking on a altered brain is that if u go into a mood thats positive and good than all the greatness u feel at that moment carry's on with u and the glow of that time stays with u, for u to charish, after a while it slowly fades but u could defintily hold on to the most important things uve learned if u decide thats what u want to do. LAST NIGHT i was out of this world! i cant stress that enough, get expensive WEED down some DXM n have a fuckin out of this world intense experience, but let me WARN u! its not for the weak minded, and u better b able to handle urself on such an intense drug or things could go badddd:) !! i would recommend being experienced moderately with mushrooms/ weed at least before moving on to something so INSANELY intense.
lol soooo in walmart we kept on talking about how ALL we cared about is GOING WILD and having a BLAST as much as we can, so when were old we can look back and be like WE ACTUALLY have a lot to reflect on, were FAR from boring, and we are very experienced individuals LOL, we had so much passion about how WILD we are and how positively crazy we are!!
MrDot
12-04-2008, 10:23 PM
DXM is by far my favorite drug and I've only did it twice, actually I wouldn't call it a drug...I would call it an eye-opening experience. I do believe it is addictive (quite a bit) After doing it last night I'm itching to take another this weekened. I will definatly cross to the other side this weekened, if I was you, don't do it once or twice a year, but hell every or every other weekened. Atleast thats what I plan, it is supeer fun.
hebrewnational00
12-04-2008, 10:34 PM
naaa buddy^^ i dont agree with u lol...
it fuckin fry's the shit out of my brain man, i dont like being brain dead, but i had such a wild experience last night! it was unbelievable
if you thought dxm was good wait til you try lsd or shrooms. makes dxm look like shit.
MeatWagon499
12-04-2008, 11:10 PM
i think he said he has tried shrooms numerous times heh. it all depends on the person really though. shrooms and LSD burnt me out far quicker than DXM. nowadays if i were to drop some cid i would have anxiety the entire time.
anyway, good to see people are opening their eyes to DXM. just be careful though it is really addicting...
CherokeeMist
12-05-2008, 12:12 AM
yeah dxm is surprisingly addicting. even though it's SO intense, it's embarrasingly easy to do it a few nights in a row.
if it weren't for having to find new stores to buy it from, i'd probably be doing it a few times a week.
MeatWagon499
12-05-2008, 12:27 AM
why do you have to find new stores to buy it from? i buy from the same store 90% of the time.
CherokeeMist
12-05-2008, 12:38 AM
why do you have to find new stores to buy it from? i buy from the same store 90% of the time.
my town is insane. i bought a few packets of morning glory seeds from a hardware store (ONE time), and a few days later there was a news story in the town paper that "teens get high off of seeds", and it said that cops were forcing stores to keep the seeds behind the counter, and to watch out for teens.
just don't want some 60 year old suburban lady to report to the police that i've bought cough syrup more than once- and i'm almost 100% sure that they would.
hebrewnational00
12-05-2008, 04:18 AM
I CANT SEE myself doing it for at least a few more months!! i really still dont feel right hehe i went TOO CRAZY last night, it was the MOST intense thing ive ever experienced by FARRR!!!
and ive done shrooms b4 so many times in so many wild setting and up until last night SHROOMS was the craziest most unique thing ever, and still different and unique in its own way, but DXM is sooooo fuckin intense! the most intense! hehe use with CAUTION people;) i would recommend more than 260 mg's. (if ur mixin with weed)
MrDot
12-05-2008, 05:08 AM
naaa buddy^^ i dont agree with u lol...
it fuckin fry's the shit out of my brain man, i dont like being brain dead, but i had such a wild experience last night! it was unbelievable
You may think your brain is fried but that's just the hangover effects, really, I doubt DXM really does any real bad long term effects, it's never been proven so obviously it's not all bad. Drinkin a bottle of Robitussin is alot healthier than drinkin a beer. The day after I robotrip, it's completly a blur, I'm out of place and just need to lay down.
hebrewnational00
12-05-2008, 03:31 PM
LOL yeaaah drinkin robitussin is better than a beer.... NOT. ur crazy man, do what u do, but i personally wouldnt recommend doing it often AT ALL for me its pretty much like a once-twice a year thing. cheers.
MrDot
12-05-2008, 08:21 PM
LOL yeaaah drinkin robitussin is better than a beer.... NOT. ur crazy man, do what u do, but i personally wouldnt recommend doing it often AT ALL for me its pretty much like a once-twice a year thing. cheers.
Do you realise what beer can do to you? Beer is proven to hurt you, DXM has not been proven to cause long term effects. Alcohal kills people, alcohal drives insane to killing people and themselves, alcohal destroys familys, alcohal causes people to do very stupid things. When you do a good dose of DXM, you're couch locked, when you drink beer you get ideas of going out and driving a car. You have alot to learn, and btw i'm not trying to be an asshole and throw it in your face but I really do believe you're wrong and alot of people would agree with me. Next you'll be saying cigerettes are safer than weed. *sigh*
hebrewnational00
12-05-2008, 09:58 PM
DXM is dangerous, MORE dangerous than alcohol, it fucks up ur coordination more than alcohol. (im talkin about when its mixed with weed)
cigaretts are more harmful to ur body but weed is more harmful to ur brain (everyday use).
MrDot
12-05-2008, 10:05 PM
I think it's actually been proven that weeed barely does anything to your brain cells.
hebrewnational00
12-05-2008, 10:05 PM
DXM FRYS ur brain more than shrooms, weed, alcohol. (in my experience) and i only dosed less than 300 mg's. and dont get me wrong i had a blast but im not doin it again for a longggg time.
hebrewnational00
12-05-2008, 10:06 PM
I think it's actually been proven that weed does damage to your brain cells. when used everyday but stay on topic.
CherokeeMist
12-05-2008, 10:31 PM
hehe use with CAUTION people;) i would recommend more than 260 mg's. (if ur mixin with weed)
did you mean "wouldn't" reccomend?
tonight i was planning on doing 300mg using the syrup, but i was gonna smoke weed on it for the first time... i'll be in my room alone all night, though, so i don't have have to ever worry about acting normal.
edit: i meant combine them for the first time- i've smoked weed a ton and done DXM on its own a decent amount.
MrDot
12-05-2008, 11:02 PM
I'm doing 8oz tonight, along with an eigth of bud, will I come back? I doubt it haha.
hebrewnational00
12-06-2008, 12:51 AM
did you mean "wouldn't" reccomend?
tonight i was planning on doing 300mg using the syrup, but i was gonna smoke weed on it for the first time... i'll be in my room alone all night, though, so i don't have have to ever worry about acting normal.
edit: i meant combine them for the first time- i've smoked weed a ton and done DXM on its own a decent amount.
YEAH man! i ment DONT recommend more than 260 lol, really 260 + killer weed was the most intense experience of my life, and if ur alone by urself and u dont have experience with shrooms, idk if i would even recommend it.... u should at least have a freind close by that u can call incase anything happens u know? cuz at one point of the my trip i was losing my mind and my freind that was also trippin calmed me down right away n i enjoyed the rest of my time...idk wat would happen if he wasnt there lol i might have LOST it completely:)
:cheers2:
CherokeeMist
12-06-2008, 03:18 AM
hmm... i'm more of a tripping alone kind of person anyway. all of my best times on psychedelics have been alone in this room. i can't really open up and feel the psychedelic experience with other people, even though i've known my friends for years.
i have no concerns about DXM; it has always treated me very well. my only problem is with weed... i had to stop smoking for a while because i just got panicky instead of high and it wasn't fun. i've started smoking again recently and it's been almost entirely positive, i just get high and it's actually enjoyable. still, though, i don't want to take one hit and have all that fear come rushing back on 300mg of DXM.
still not sure yet.
pedaltopedal
12-06-2008, 03:36 AM
I don't smoke weed anymore because it makes me way too anxious and even slightly paranoid at times. However, I still find it mixes well with DXM. I don't get paranoid or anxious, as it almost feels as if the DXM calms me down and quiets my inner dialogue. I feel right at home on DXM. Weed does, however, make the DXM high extremely weird in ways I cannot even begin to describe. It's strange, to put it lightly, so it might take you by surprise a little at first, but I think you're going to like it. ;)
Your experience may vary, however. Everyone is different.
If you're worried about it, then just start a little lower than you were planning just to be safe.
300mg is such a low dose. double that and then i'll know you went through an INTENSE experience... with weed of course. :D you'll definitely be couch locked then. put on the Are You Shpongled album and ur in for a real crazy night. 300mg haha, i guess it effects us all differently cuz at that low dose i just feel drunk, have u ever felt the actual dissociative effects?
Mr.Writer
12-06-2008, 03:44 AM
if you thought dxm was good wait til you try lsd or shrooms. makes dxm look like shit.
Apples and oranges :) LSD is 10/10 for me, but so is dxm/ketamine (they are virtually the same high).
CherokeeMist
12-06-2008, 04:00 AM
hmm good to know pedaltopedal... i think i may start at 250 and see how it goes.
300mg is such a low dose. double that and then i'll know you went through an INTENSE experience... with weed of course. :D you'll definitely be couch locked then. put on the Are You Shpongled album and ur in for a real crazy night. 300mg haha, i guess it effects us all differently cuz at that low dose i just feel drunk, have u ever felt the actual dissociative effects?
well i'm really small (54 kg), so 300mg is a moderate-strong second plateau dose. i've felt some interesting things at this dose (intense flanging, mostly visual, and music takes on colors, shapes, and dimensions in my eyelids. i've also felt like my nose wasn't "there", and like it was a box composed of two wind tunnels). i haven't actually fallen back into the third plateau yet, i don't think i'm ready for something that intense.
CoLdFuSioN167
12-06-2008, 04:42 AM
I've done acid and shrooms before but I don't think that I will ever do dxm. Just the idea of getting high of cough medicine kind of turns me off.
Anyway - glad that your trip was good. Did you happen to take lots of pics? If so, you should post them here.
hebrewnational00
12-06-2008, 05:38 PM
NOPE i wanted to film a video lol, thats why we WALKED to walmart but we freaked out when we got there so we didnt end up buy a camcorder:(
ITS CRAZY cuz gettin high on cough medicine REALLY turned me off at first but once u get high on it ur like.. WOW!! how is this not a DRUG like a street drug, u know? i can this drug being regulated as something VERY illeagal. its sooooo fuckin intense, i cant get over it.
Mr.Writer
12-06-2008, 06:34 PM
Being turned off because it's used in cough medicine is pretty retarded. That means you shouldn't ever do codeine either. Better not touch any opiates in fact, since they all supress cough mechanism, like dxm.
Oh shoot, ketamine is a tranquilizer in higher doses, better not touch that, don't wanna look dumb.
Ah crud, heroin and cocaine used to be legal and used in everthing from toothache remedies to flavouring soft drinks. Better not touch that, that's just gay.
Marijuana is used to make clothing? WTF, how retarded. I'm throwing all my weed away.
LSD was used by the CIA as an experimental truth serum? How dumb, i'm never doing acid again.
Whoa, look at that, if you judge a drug by it's legitimate use then all drugs are "stupid".
It's a good thing the legitimate use of a drug has no impact on the effects of a drug and it's inherent value recreationally.
CherokeeMist
12-06-2008, 07:42 PM
Being turned off because it's used in cough medicine is pretty retarded. That means you shouldn't ever do codeine either. Better not touch any opiates in fact, since they all supress cough mechanism, like dxm.
Oh shoot, ketamine is a tranquilizer in higher doses, better not touch that, don't wanna look dumb.
Ah crud, heroin and cocaine used to be legal and used in everthing from toothache remedies to flavouring soft drinks. Better not touch that, that's just gay.
Marijuana is used to make clothing? WTF, how retarded. I'm throwing all my weed away.
LSD was used by the CIA as an experimental truth serum? How dumb, i'm never doing acid again.
Whoa, look at that, if you judge a drug by it's legitimate use then all drugs are "stupid".
It's a good thing the legitimate use of a drug has no impact on the effects of a drug and it's inherent value recreationally.
:cheers2: very well said.
DXM is a chemical, just like any other drug. the fact that it's in cough medicine just means there's an easy, reliable way to get it- and conveniently enough, with an exact way to measure your dose. don't let the image turn you off.
hebrewnational00
12-06-2008, 09:13 PM
TRUE ^^^ that just means u can buy it easier, its legal, u know how much ur taking, and its quite frankly SAFER to take than street drugs. dont let that fool you that it is LESS intense or less potent than illegal drugs:)
salmon4me
12-07-2008, 01:55 AM
Drinkin a bottle of Robitussin is alot healthier than drinkin a beer. The day after I robotrip, it's completly a blur, I'm out of place and just need to lay down.
uh...notice anything a little off about this statement? LOL
Loki557
12-07-2008, 02:04 AM
I just think it is ironic how all the people putting DXM down just because it is a cough medicine. Are the ones that complain about others thinking all drugs are bad for you just because they are called "drugs".
I love irony.
Mr.Writer
12-07-2008, 04:22 AM
So true
"I won't do heroin, that's a hard drug."
"I won't do dxm, that's cough medicine"
lol, so self-limiting, it fills me with pity
MrDot
12-07-2008, 07:42 PM
It's a blur, that doesn't mean its hurting me lol. I don't limit myself to any drug because of what it might do, I'll do anything, why? Well you can't say jack untill you've took the ride.
hebrewnational00
12-07-2008, 09:07 PM
mrdot is smart, at least. (-_-) hahahaha :)
espfeelit
12-07-2008, 09:14 PM
do 20 robotussin gel tabs and 12 benydril tabs
MrDot
12-07-2008, 10:58 PM
mrdot is smart, at least. (-_-) hahahaha :)
Hebrew, we gotta meet somewhere inbetween man lol.
To much argueing, lets agree to disagree. :D
i0-techno
12-07-2008, 11:10 PM
Ha I wouldn't do meth, I think everyone has a choice on setting boundaries so they can trip harder next time and not be ripped and torn to shreds just because they like getting tripped on. Nothing wrong with a limit, nothing wrong with going no holds barred either. Judging what another is doing is the fucking joke on self.
MrDot
12-08-2008, 12:49 AM
Ha I wouldn't do meth, I think everyone has a choice on setting boundaries so they can trip harder next time and not be ripped and torn to shreds just because they like getting tripped on. Nothing wrong with a limit, nothing wrong with going no holds barred either. Judging what another is doing is the fucking joke on self.
Hmm, I would do meth if given the chance. It's not as addicting as everyone says, well come on, they say pot is super addicting as well. A few of my friends have tried it, disliked it, and just didn't do it anymore. Even if you do like it there is always self-control, ALWAYS!
pedaltopedal
12-08-2008, 12:55 AM
You're right... there is always self control. However, things can change after you try it the first time. I'm not saying you'll instantly be hooked, but its likely your attitude and self control towards the drug will change once you try it. It happens to people all the time who just want to "Try it only once to see what its like" and then before they know it they've fallen completely in love with the drug and get hooked.
And your parents and DARE officer were lying when they said pot was dangerous and addicting. They weren't lying when they said that about meth, though. It's too bad they don't get there facts straight... otherwise it leads to these sorts of false conclusions about drugs. So sad.
i0-techno
12-08-2008, 01:58 AM
Yea really, I work with a meth head, he is ashamed to be real with me about that shit, you can see his teeth going, but he isn't so bad yet, but it has full and utter control over his doings, I have just never seen any good shit come from it, but this body here is not touching meth, you can do whatever you like Mr. Dot.
MrDot
12-08-2008, 02:06 AM
Yea really, I work with a meth head, he is ashamed to be real with me about that shit, you can see his teeth going, but he isn't so bad yet, but it has full and utter control over his doings, I have just never seen any good shit come from it, but this body here is not touching meth, you can do whatever you like Mr. Dot.
I suppose some people just have a more addicting mind state, ever since I did DXM for the first time in a highh dose all I wanted to do is do DXM. I can see myself doing it every weekened, it probally wont happen but my mind sees it happening. I've become addicted to muscle relaxers before, can eat an anti depressant like its candy anymore, but when things got to the point where it hurt my body I said no more, and then there was NO MORE. lol I suppose some people just go to points of no return, tell your friend to look at pictures of meth mouth, should make him stop. ha.
nickers224
12-09-2008, 01:32 AM
uh sorry this is a little off-thread but what do you guys suggest as a good first dose (in mgs) of gel capsules because im thinking about trying some either this weekend or next
thanks in advance
MrDot
12-09-2008, 01:37 AM
uh sorry this is a little off-thread but what do you guys suggest as a good first dose (in mgs) of gel capsules because im thinking about trying some either this weekend or next
thanks in advance
Uhm, about 300-400mgs, just drink a 4oz bottle of robitussin that has only DXM as active ingrediant, 1 4oz bottle will do alot for you.
Stephζ
12-09-2008, 02:51 AM
You can't say that about the 4oz, Dot, unless you know how much he weighs. How much ya weigh, nickers?
hebrewnational00
12-09-2008, 05:21 AM
if ur smokin weed with it i wouldnt do more than 250mg's for ur first time.... if the weed is really good than 200 mgs should do that trick. (assumin u weigh around 135lbs)
Mr.Writer
12-09-2008, 05:38 AM
200mg? He might not feel anything . . . 400 is good for first time. My first time was with 650 and it was one of the best drug experiences of my life.
Stephζ
12-09-2008, 04:56 PM
I agree with mr writer. If you weigh more than 150 though then you should up it 50mg for every 10lbs.
hebrewnational00
12-09-2008, 05:07 PM
i weigh about 145lbs and i took 280mg approx... and smoked REALLY good weed, and idk what i would have done if it was anymore intense... but go for it. im just talkin from my experience.
StonerBill
12-09-2008, 05:49 PM
I think some of you need to realise that cough syrup is a dense sludge of sugars, artificial sweeteners, thickener, and preservatives. its really unhealthy to include in your diet.
as for dosages.. everyone is so different. i took 300 and had a mild buzz and 600 got me 'trippin' in whatever way you could call dxm.
ps. i loved it! thumbs up.. except for the cough syrup bit. the high is really unique.. it would be good if dealers extracted it and sold it alongside K
espfeelit
12-09-2008, 06:24 PM
extraction is very possible. if i had me 3000 mg of extracted DXM, i would be very happy, although my liver wouldnt. i heard of people i know taking extracted DXM, they say the high isnt the same.
MrDot
12-09-2008, 06:39 PM
Yeah, I considered doing this, buying alotta delsyum and extracting the DXM from it, just for the simple fact of, I'm tired of the cough syurp.
espfeelit
12-09-2008, 06:53 PM
yeah, not to mention the holes in the brain deal, doesnt sound too promising
MrDot
12-09-2008, 07:04 PM
Holes in the brain? wtf lol
espfeelit
12-09-2008, 07:06 PM
yeah, it puts them there, as does your liver suffer.
MrDot
12-09-2008, 07:14 PM
That is, if you mix it with a bunch of random shit. There is actually no true facts about what dxm alone will do to your system, personally I love it when a kid will chug a whole bottle of cough syurp with dxm and other deadly stuff combined, my buddy came over and started chugging nyquil, i laughed and let him.
espfeelit
12-09-2008, 07:15 PM
haha. true. acetometaphin, a deadly advocate of live damage
MrDot
12-09-2008, 07:20 PM
Yeah, you can get alot of DXM only cough suppressants but no one actually knows the dangers of DXM completly, it's unchartered territory. Territory i'm willing to venture into!
A question of mine is, if mixed with valiums and stuff is it possible to give you the itch? Idk, yesterday (after of weekened doing 8oz of DXM) I got itches really bad all over my body, the only thing I did was valium and DXM so I'm confused about this. Could be my body saying eat another valium though, when I do alot of muscle relaxers over a long amount of time my body breaks out into bad muscle spasms once I haven't had it. Obviously this is addiction beating the fuck outta my body.
Hippie McRaver
12-09-2008, 07:28 PM
Running Head: SIDE EFFECTS OF DEXTROMETHORPHAN ABUSE
Abstract:
The aim of this study was to investigate dextromethorphan (DXM) abuse side effects. Subjects were 53 volunteers who had consumed DXM with a mean age of 23.4 years. The mean of side effects during first day was 12.49 and during the first week was 5.57. The causes of repeated DXM abuse were psychological dependency (46.5%), recreational abuse (32.6%). Neurological and psychological symptoms were the most common of side effects in DXM abusers. (PsycINFO Database Record (c) 2008 APA, all rights reserved)(from the journal abstract)
Results:
Forty-eight males and five females participated in this study. The mean age of subjects was 23.4 years (range: 2028 years old, SD = 1.83). Nine subjects (18.9%) did not have a history of consuming DXM for any medical purpose and other subjects had used DXM for chronic cough and cold with physician's prescription.
Twenty-nine subjects (54.7%) abused DXM more than 10 times and twenty-eight subjects (52.8%) had history of DXM abuse for more than 3 years. The mean of frequency of DXM abuse was 25.5 (range: 1200, SD = 41.09) and the mean of first and last dosage of DXM abuse in our subjects was 336.3 (751125) and 623.5 (902700) mg, respectively. Fifty-one people (92.5%) reported history of other illicit drug without any addiction criteria (according to DSM-IV). The most common illicit substances which were abused by our subjects are listed in Table 1.
Table 1.
The most common illicit substances which were abused by our subjects
Illicit substances Frequency (%)
Alcohol 51 (96.2)
Marijuana 47 (88.7)
Sedatives 38 (71.7)
LSD 36 (67.9)
Morphine 29 (54.7)
Ecstasy 28 (52.8)
Cocaine 16 (30.2)
Heroin 13 (24.5)
Phencyclidine 11 (20.7)
Special K (Ketamine) 11 (20.7)
Others 13 (24.5)
Full-size table
View Within Article
According to participants, 3.8% had history depression and anxiety in the last year which they did not receive any treatment. In this study, all subjects experienced minimally 3 adverse effects during the first day and 51 subjects experienced minimally 1 adverse effect during the first week. The mean of side effects during the first day was 12.49 (range: 328, SD = 5.71) and during the first week was 5.57 (range: 014, SD = 3.38). Table 2 shows the adverse effect of DXM and frequency of everyone during the first day and first week (17 days) after the last abusing dose of subjects. All of the subjects had 3 side effects at least, although no emergency care was needed in them.
Table 2.
Adverse effect of DXM reported by research subjects
Autonomic side effects
Sweating
Tachycardia
Fatigue
Tachypnea
Flushing
Cool feeling
Gastrointestinal side effects
Nausea
Vomiting
Diarrhea
Constipation
Neurological side effects
Dyskinesia
Speech disorder
Dizziness
Mydriasis and photophobia
Blurred vision
Diplopia
Imbalance
Dysaphia
Tremor
Psychological side effects
Euphoria
Trance
Apathy
Laughing
Tongue biting
Auditory hallucination
Visual hallucination
Insomnia
Nightmare
Anhedonia
Dysmnesia
Hyper vigilance
Attention deficit
Learning impairment
Flash back
Panic disorder
Hyperactivity and inclination to dance
Sexual side effects
Increased libido
Decreased libido
Inclination to make love 16
Others
Itching
Fatigue
Urticaria
Myalgia
Icterus
Facial edema
Reinforcement
The causes of repeated DXM abuse were psychological dependency 46.5% (20 subjects), recreational abuse in 32.6% (14 subjects) and physiological dependency in 2.3% (one subject).
4. Discussion
Our purpose in this study was to assess adverse effect of DXM in young adult abusers. DXM is absorbed quickly from the gastrointestinal tract; (within 30 min) and its duration of effects is about 36 h (half-life of about 24 h) (Shaul, Wandell, & Robertson, 1977). So after DXM abuse, many side effects especially gastrointestinal adverse effect are seen during a few hours and it is more common than in the future days. Despite frequent consumption of DXM by our patients, they did not have to refer to emergency care at the time of abuse. It can be due to low half-life of DXM.
Dextrophan acts as phencyclidine (PCP) in the brain and the toxic effects of PCP and DXM are similar together (Jahng et al., 2001, Sharp, 1997 and Wolfe & Caravati, 1995).
In this study, there was no death and any adverse effect in patients that needed medical support, although there are some people who are at increased risk of side effects of DXM with its normal dosage like those who take it along with MAO inhibitors and serotonin reuptake inhibitor drug use or those with P450-2D6 enzyme polymorphism (Sharp, 1997).
Euphoria, altered time perception, feeling of floating, visual disturbance, tactile, visual and auditory hallucination, disorientation and increased perceptual awareness are primary psychological symptoms that were identified by Krenzelok (1990), Miller and Gold (1991), Wolfe and Caravati (1995). In our study, hallucination and flash back prevalence were 50.9% and 52.8%, respectively and our subjects abused DXM for these reasons. Hallucination states that are seen in DXM abuse, is similar to LSD, PCP abusers and MDMA (Ecstasy) (Wolfe & Caravati, 1995 and Yoo et al., 1996).
DXM is available in various combinations with other medications, and approachability of this drug in Iran is not controlled. For these reasons, DXM abuse is being increased every day.
Jasinski (2000), Liu et al. (2003) and Zapata et al. (2003) showed DXM reduced withdrawal symptoms and attenuates the behavioral or toxic effects of cocaine by reduction in opiate substance requirements and it is one of the causes of DXM abuse in addicted people. It also prevents hyperthermia in amphetamine drug abusers such as Ecstasy (Farfel & Seiden, 1995).
According to Jones, Gallagher, and McFalls (1988), drug abuse can be classified into two categories: licit and illicit psychoactive drugs. Also, there are five forms of abuse including: experimental use, social recreational use, circumstantial, intensified and compulsive use. Murray and Brewerton (1993) believed DXM is a nonaddictive licit drug that does not have physiological or psychological dependency, although produces a substance dependence syndrome. In this study, although 18 subjects had to abuse DXM again, it is probably abused in circumstantial or intensified forms and others abuse DXM recreationally. According to Momodou (1996), DXM is abused because it is more readily available, cheaper and more socially acceptable than other licit substances. It is not associated with any widely known effects and its physiopsychological implications are not fully established or known to the potential abuser population.
Conclusion:
Dextromethorphan abuse is a potential social problem in the future and availability of DXM over the counter to all age groups must be revised.
References:
Andaloro et al., 1998 V.J. Andaloro, D.T. Monaghan and T.H. Rosenquist, Dextromethorphan and other N-Methyl d-Asparate receptor antagonists are tratogenic in the avian embryo model, International Pediatrics Research Foundation 43 (1998) (1), pp. 17. View Record in Scopus | Cited By in Scopus (27)
Bem & Peck, 1992 J.L. Bem and R. Peck, Dextromethorphan. An overview of safety issues, Drug-Safety 7 (1992) (3), pp. 190199. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (117)
Bidaga et al., 1997 A. Bidaga, P. Gianelli and P. Popik, Opiate withdrawal with dextromethorphan, American Journal of Psychiatry 9 (1997), pp. 413425.
Cranston & Yoast, 1999 J.W. Cranston and R. Yoast, Abuse of dextromethorphan, Archives of Family Medicine 8 (1999) (2), pp. 99100. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (22)
Darboe et al., 1996 M.N. Darboe, S.R. Keenan and T.K. Richards, The abuse of dextromethorphan-based cough syrup: A pilot study of the community of Waynesboro, Pennsylvania, Adolescence 31 (1996), pp. 633644. View Record in Scopus | Cited By in Scopus (24)
Farfel & Seiden, 1995 G.M. Farfel and L.S. Seiden, Role of hypothermia in the mechanism of protection against serotonergic toxicity: II. Experiments with methamphetamine, p-chloroamphetamine, fenfluramine, dizocilpine and dextromethorphan, Journal of Pharmacology and Experimental Therapeutics 272 (1995) (2), pp. 868875. View Record in Scopus | Cited By in Scopus (76)
Jahng et al., 2001 J.W. Jahng, T.Y. Zhang, S. Lee and D.G. Kim, Effect of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rates, European Journal of Pharmacology 431 (2001), pp. 4752. Article | PDF (180 K) | View Record in Scopus | Cited By in Scopus (6)
Jasinski, 2000 D.R. Jasinski, Abuse potential of morphine/dextromethorphan combinations, Journal of Pain and Symptom Management 19 (2000) (1 Suppl.), pp. S26S30.
Jones et al., 1988 B.J. Jones, B.J. Gallagher and J.A. McFalls, Social problems: Issues, opinions and solutions, McGrawhill, New York (1988).
Krenzelok, 1990 E.P. Krenzelok, Non-prescription cough medicine abuse, Clinical Toxicology Forum 2 (1990), p. 5.
Liu et al., 2003 Y. Liu, L. Qin, G. Li, W. Zhang, L. An and B. Liu et al., Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation, Journal of Pharmacology and Experimental Therapeutics 305 (2003) (1), pp. 212218. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (65)
Miller & Gold, 1991 N.S. Miller and M.S. Gold, Organic solvent and aerosol abuse, American Family Medicine 44 (1991) (1), pp. 183189. View Record in Scopus | Cited By in Scopus (8)
Momodou, 1996 D.N. Momodou, Abuse of dextromethorphan-based cough syrup as a substitute for licit and illicit drug: A theoretical framework, Adolescences 31 (1996) (121), pp. 239245.
Murray & Brewerton, 1993 S. Murray and T. Brewerton, Abuse of over-the-counter dextromethorphan by teenagers, Southern Medical Journal 86 (1993) (10), pp. 11511153. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (29)
Roberge et al., 1999 R.J. Roberge, K.H. Hirani, P.L. Rowland, R. Brekeley and E.P. Krenzelok, Dextromethorphan and pseudoephedrine induced agitated psychosis and ataxia: Case report, Journal of Emergency Medicine 17 (1999) (2), pp. 285288. Article | PDF (59 K) | View Record in Scopus | Cited By in Scopus (20)
Sharp, 1997 J.W. Sharp, Phencyclidine PCP acts at sigma sites to induce c-fos gene expression, Brain Research 758 (1997), pp. 5158. Article | PDF (1616 K) | View Record in Scopus | Cited By in Scopus (29)
Shaul et al., 1977 W.L. Shaul, M. Wandell and W.O. Robertson, Dextromethorphan toxicity: Reversal by naloxone, Pediatrics 59 (1977) (1), pp. 117118. View Record in Scopus | Cited By in Scopus (11)
Wolfe & Caravati, 1995 T.R. Wolfe and E.M. Caravati, Massive dextromethorphan ingestion and abuse, American Journal of Emergency Medicine 13 (1995) (2), pp. 174176. Article | PDF (360 K) | View Record in Scopus | Cited By in Scopus (41)
Yoo et al., 1996 Y. Yoo, H. Chung, E. Kim and M. Kim, Fatal zipeprol and dextromethorphan poisonings in Korea, Journal of Analytical Toxicology 20 (1996), pp. 155158. View Record in Scopus | Cited By in Scopus (13)
Zapata et al., 2003 A. Zapata, M. Gasior, D.B. Geter, F.C. Tortella, A.H. Newman and J.M. Witkin, Attenuation of the stimulant and convulsant effects of cocaine by 17-substituted-3-hydroxy and 3-alkoxy derivatives of dextromethorphan, Pharmacology, Biochemistry and Behavior 74 (2003) (2), pp. 313323. Article | PDF (217 K) | View Record in Scopus | Cited By in Scopus (3)
Ziaee et al., in press Ziaee, V., Akbari, H.E., Hoshmand, A., & Saman, K. (in press). Abuse of dextromethorphan: Review and a case report. International Journal of Pharmacology, 1(4) (in press).
retrieved from PsychINFO, from EBSCO database found at UMass Dartmouth
MrDot
12-09-2008, 07:33 PM
That kinda fails man, considering they had past experience with drug abuse.
espfeelit
12-09-2008, 07:35 PM
dont forget good ol psychosis.
espfeelit
12-09-2008, 07:39 PM
http://en.wikipedia.org/wiki/Olney%27s_Lesions
MrDot
12-09-2008, 07:54 PM
Hmm, if it kills me or puts a hole in my brain, SO WHAT? Atleast I can look back and say to others, "Hey I lived my life, I did what I wanted, I felt what it was like to live."
espfeelit
12-09-2008, 08:58 PM
true. i am happy without a dissociative.
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