methylating Phenethylamine

[psyclonnine]

what would your end product be if you were to methylate PEA with something like methyl iodide

[StonerBill]

unfortunately, probably nothing useful

[Geneity]

well considering amphetamine is alpha-methyl-phenethylamine.....amphetamine?

I THINK the alpha just refers to the methyl groups position, but I could be totally wrong.

[LSDMIKE]

if you methylate it with methyl iodide this would add a methyl group giving you N,N dimethyl-amphetamine.. not going to get you very high

[Geneity]

trimethyl-phenethylamine (lol)? Wow. How does methyl iodide add THREE methyl groups? That could probably be avoided by using less. Otherwise you'll over saturate the molecule with methyl groups it seems.

Idk.

[psyclonnine]

perfect its not a drug i'm after its a predecessor
are you sure on the N,N dimethyl-amphetamine.

[Geneity]

^ I'm no chemist but that sounds way over saturated. If anything you'd make methyl-phenethylamine. You wanna try and get that methyl group in the 'alpha' position. If it winds up in the beta position you'll be fucked.

Then again I still may have no idea what the fuck I'm talking about.

Google is pretty great. Search methylating phenethylamine. Then you should have a decent idea of what can happen.

[psyclonnine]

not much on google
in the case the methyl groop douse end up in the beta wouldn't you still have a stimulant drug
what about methylateing Dopamine

[Geneity]

well you'd end up with Diamondina (beta-methyl-phenethylamine) which is a stimulant like amphetamine with all the stimulation and none of the euphoria. That sounds quite annoying.

Methylating dopamine probably wouldn't do anything useful.

[psyclonnine]

no neat Methylenedioxy compounds then
methylating phenethylamine might be worth a try tho

[psyclonnine]

if someone wanted to be really brave what about methylating Tyramine
you might get something smiler pma

[orison319]

Fast Forward Pharmacology........
http://jpet.aspetjournals.org/cgi/content/full/321/3/1054

[psyclonnine]

thank you :)

[psyclonnine]

douse anyone know exactly what methylating Tyramine would yield

[orison319]

-phenylethylamine synthesized exclusively within dopamine neurons? ... N,N-dimethyltryptamine is synthesized from a two-step methylation reaction each .. Prolly what your looking for? but I cant access it.


get to know Spiritual Alchemy http://biologyofkundalini.com/article.php?story=supplementlist

[LSDMIKE]

http://designer-drugs.com/pte/12.162.180.114/dcd/chemistry/amphetamine.methylation.html

N,N dimethyl-phenethylamine..maybe i think so!

[Geneity]

heh Para-methoxy-amphetamine. What a nasty chemical. Would you actually take that shit?

[Geneity]

Monomethylating amphetamine? Sounds like meth to me.

[psyclonnine]

.. Prolly what your looking for? but I cant access it

Tyramine ? easy to find

[orison319]

tyramine is suspected as a possible cause of migraine headaches..

I dont want none of that stuff.. LOL.

[psyclonnine]

so could you methylate Tyramine in to pma
and PEA in to amphetamine or something like it

[Geneity]

Whatever you do stay the fuck away from PMA. Tyramine is in a lot of food and supplements. It's a basic amino acid....

[orison319]

yeah its a why I put that Spiritual Alchemy stuff..

Good mind, body and spirit in common foods.. or supplements..

[LSDMIKE]

PMA No one likes it anyway, you want sell it to the same person more than onec
that i know..

[psyclonnine]

meh i dont mind it tooo much
synthing it would be redundunt tho
i can buy it dirt cheap anyway

woulden't those 2 hydroxyl groops on the back of dopeamine methylate into a Methylenedioxy groop
if so what an easy X synth

[Geneity]

^ If they did it would have been done.

[fryingsquirrel]

so could you methylate Tyramine in to pma
and PEA in to amphetamine or something like itI've spent more time than is probably healthy researching routes to amphetamine, and I've seen absolutlely nothing like that. It's a fairly obvious route, if it were possible it seems likely it would have come up as a topic on the hive, or in Strike and Fester's books. It didn't.

[psyclonnine]

anyone know a reason it wouldent work

[Rnegade]

N,N dimethyl phenethylamine