In you're opinion, which of these drugs causes the most brain damage?

[ssj3gotenks]

I hear a lot about how pot kills brain cells and X puts holes in your brain and how meth causes a loss of dopamine but that is what i hear in school and i want to know what YOU all think, since i listen to you all more since YOU GUYS CAN BACK UP WHAT YOU SAY.

[mellow]

well first off, X does not put 'holes in your brain', that was a myth...

it hard to say, every drug has its advantages and disadvantages...The worst on that list (not in any particular order) are:

meth
heroine
crack
inhalants


I dont know why you would want to go near any of those in the first place, but hey its your choice...

I'm sure inhalants like bleach and gasoline cause some of the most negative effects, not to mention the addictive and physically destructive nature of meth, heroine, and crack.
But anyways, check Erowid for more info on health and such.

[Turn]

I am no expert but I do know this much, inhalents are the worst drugs for your brain. The things you huff give you a high because it is damaging your brain. BUT Nitrous Oxide, I belive is very safe, thats why dentists use it. Also alcahol is pretty bad for your brain too, and heroine is fine it has no long term damage.

[MagicMedicine]

dude, i dont care what X does, it will always be my abuse of choice.

[soaringeagle]

tough call there
inhalants definately, then xtc then alcahol. lsd..if really heavily used..dont know enough about dxm
i think the rest are mostly hard on your body not mind weed is definately safest

[TheMistress]

inhalents directly cause brain damage, while most of the other drugs listed cause nerve damage, and/or affect the lungs/heart.

so I say inhalents cause ultimate brain damage.....

In the words of homer simpson: "I hope I didn't brain my damage"

[Rearden Metal]

Yeah, I'd have to say that huffing glue in particular is the absolute worst thing you can do to your brain without a shotgun. While not that popular in the U.S., South American street children commonly huff glue, and it litterally makes the users mentally retarded. Very heavy nitrous use depletes certain vitamins from your body (B12 and folic acid, right?), which causes pain in the joints (Knees, elbows, etc...) but not brain damage.


Tweekers mess up their bodies real bad, but is there brain damage?

[PLyTheMan]

Well, I know technicly NO can be harmless to you brain, other inhalents and misuse of NO can definitely damage it. I didn't realize that other inhalants were covered by NO, though, so I picked DXM. I know Robotripping is bad for your kidneys and body in general, I think over use is dangerous for you brain too.

From what I've gathered, repeated LSD use is not physicaly dangerous but it will definitely fuck up your mentality and personality if overused/abused.

I really dont know about Heroin and coke, I've never really read up a whole lot on them because those are a few drugs I'm sure im never going to touch, so I dont know if they're dangerous for you head or not...

[oOflyeyesOo]

I would say inhalents, but nitrous oxide is realitivly harmless so that should be changed to like air duster or something.

But then again meth is really a fucking horrible drug, I have seen so many rotted face's and fucked up bodys from it, it makes me so sad to see it so im thinking meth might be worse.

[hippypaul]

Alcohol Number 1 by far and away - huge amount of damage - fetal alcohol syndrome - major contributor to accidents, crime, etc
Inhalants a distant number 2

[deadonceagain]

tough call there
inhalants definately, then xtc then alcahol. lsd..if really heavily used..dont know enough about dxm
i think the rest are mostly hard on your body not mind weed is definately safestlsd does not cause brain damage and DXM realy isnt studyed enough but it does cause brain damage,E as far as i know doesnt casue any brain damage,neither does heroin,N2O,or marijuana,you should realy fix your list man most of the drug on it dont damage the brain,but i would have to say meth,PCP,crack/cocaine, inhalents are by far the worst be it depends on what ones your talking about N2O doesnt cause damage and ether realy isnt that bad it was used by doctors for a long time

[synaptic aether]

i would say that inhalants do but not nitrous oxide... but that's not an option.

how i understand it, the rest are only physically harmful when used by idiots.

i also wouldn't call a lot of inhalents drugs. i mean, i suppose they can be considered a drug but then again, almost anything can be considered a drug. they seem to be as much of a drug as hitting yourself in the head really hard untill desired effects are achieved. 0.o

http://www.erowid.org/chemicals/nitrous/
http://www.erowid.org/chemicals/inhalants/

[nesta]

yeah, nitrous oxide, if used in a relatively safe manner, will do little to no long-term damage save perhaps a nearly negligable level of B12 depletion, which isn't long term and can easily be fixed as far as i know. it is not at all in the same vein as most inhalants, which generally work on the basis of asphyxiation.

of what is listed, i'd say that alcohol is probably the most common cause of brain damage, but the damage that can potentially (not definitely) be caused by DXM is probably to a more drastic degree in heavy users. the only others i would suspect would commonly cause significant brain damage would perhaps be ungodly large doses of methamphetamine and its close cousin, mdma. perhaps cocaine type drugs can be damaging as well, i wouldn't be surprised but i dont know for a fact that they do.

i chose DXM.

[Spyder]

acid everytime, cos it'll just wipe you out

[nesta]

acid causes no manner of brain damage at all.

feeling drained is different than having brain damage.

[SunshineLovePeace]

dude, i dont care what X does, it will always be my abuse of choice.
agreed.

[greengoddess]

I think meth.... I'd never do it!

[TopNotchStoner]

I tried X for the first time last night and it was great, but I can't imagine using it more than maybe once a month because it seems like it could get old pretty quick.

[ssj3gotenks]

i really have a hard time deciding between meth, E, and inhalants. First of all, the "MA" in MDMA stands for methamphetamine, which to me means that MDMA will cause the same damage as normal meth, if not, more. But that is just a stance of mine, not a fact. And i'm almost certain that longterm meth use causes a loss of either dopamine, dopamine receptors, or both. And to top that off, what makes me think this is how i see how people who use E and ice for a long time are severely depressed for days and days at a time.

I'm thinking as i'm typing this that E/ice causes brain damage like inhalents, but in different ways. As stated above, ice/E may tamper with dopamine and/or receptors, but being really depressed is different from being really stupid. I mean, i knew a guy who used inhalants numerous times and when he was off for like 2-3 months, he still couldn't even remember his own zip code!

so i guess the real answer between ice/E and inhalants is in my opinion, they cause damage, sometimes major sometimes moderate sometimes minor, but you can't say one is worse than the other because they f*** your brain up in different ways.

[StonerBill]

how about a neuroscientific approach?

alchohol has two main functions, one is as a GABA stimulator, just like benzo's. this is the neurochemical effect of alchohol, and why benzos can be used for alchohol withdrawal. this is not the dangerous part of alchohol. ethanol is a solvent. the walls of neurons are made of oils and fats, and alchohol dissolves teh outer layers, leading to imbalance of electrical signals flowing through them. if you drink too much, you destroy tirhg thtrough these walls and kill te neuron.

inhalants are solvents. however often much stronger than ethanol, and i dont think they have GABA effects (or at least teh same type), and so inhalants pretty much do all of their effects by dissolving neurons, and preventing flow of oxygen and the like.

meth and other amphetamines stimulate teh release of dopamine, and prevent the reuptake of dopamine. cocaine simply prevents the reuptake of dopamine. what this means is that extensive use of coke will lead to your brain's chemistry buggering up leading to cravings and depression etc. amphetamines however have added problems in that they flood your brain with dopamine, and too much use of meth and ice and that will actually lead to poisoning yourself with dopamine. this may kill neurons but not at the rate of solvents. excessive use however can simply lead to neurons not functioning.

overuse of opiates is not dangerous, however excessive opiate -withdrawal- may be harmful to your brain. dont know much abiout that though.

ecstacy is a risky topic. using it all teh time means flooding your brain with chemicals. if you do this too much, it will do just the same as meth, but potentially worse due to the extra effects on serotonin and not just dopamine. however.. most people dont take X nearly as much and frequently as those who are addicted to ice.
overuse of ecstacy most probably will lead to malfunctioning of neurons, but this is hard to measure and so people will still continue to believe that no matter how much X you take, youll be fine.

acid and weed wont cause brain -damage-, however, when your thoughts are exessively re-directed with drugs, the brain will start to develop in different ways, particularly when these drugs ar taken in adolescence. this brain development can be permanent, and with some brain types and genetic predispositions (which cant be detected really), this can lead to psychological diseases. in other people it can simply lead to eccentric or unusual personalities and thought patterns, but not damage to the physical brain.

one must remember however that when certain channels of the brian are opened up by drugs, the brain will try to develop more neurons on that 'channel' and eventually discard those channels that arent used. and so, when using any drug too much, it can lead to you brain merely being moulded around the use of the drug, and ability to think in terms of redundant things can deteriorate. for example, meth-heads can begin to see the world totally in measures of getting more meth, seeing other humans merely as tools or vehicles for meth, losing sense of love or compassion, since these deteriorate in favour of more accessable, instant rewards and motives of the drug.


most brain-damage?
solvents
(petrol, air-duster, glue fumes, turps, etc)

[TopNotchStoner]

how about a neuroscientific approach?

alchohol has two main functions, one is as a GABA stimulator, just like benzo's. this is the neurochemical effect of alchohol, and why benzos can be used for alchohol withdrawal. this is not the dangerous part of alchohol. ethanol is a solvent. the walls of neurons are made of oils and fats, and alchohol dissolves teh outer layers, leading to imbalance of electrical signals flowing through them. if you drink too much, you destroy tirhg thtrough these walls and kill te neuron.

inhalants are solvents. however often much stronger than ethanol, and i dont think they have GABA effects (or at least teh same type), and so inhalants pretty much do all of their effects by dissolving neurons, and preventing flow of oxygen and the like.

meth and other amphetamines stimulate teh release of dopamine, and prevent the reuptake of dopamine. cocaine simply prevents the reuptake of dopamine. what this means is that extensive use of coke will lead to your brain's chemistry buggering up leading to cravings and depression etc. amphetamines however have added problems in that they flood your brain with dopamine, and too much use of meth and ice and that will actually lead to poisoning yourself with dopamine. this may kill neurons but not at the rate of solvents. excessive use however can simply lead to neurons not functioning.

overuse of opiates is not dangerous, however excessive opiate -withdrawal- may be harmful to your brain. dont know much abiout that though.

ecstacy is a risky topic. using it all teh time means flooding your brain with chemicals. if you do this too much, it will do just the same as meth, but potentially worse due to the extra effects on serotonin and not just dopamine. however.. most people dont take X nearly as much and frequently as those who are addicted to ice.
overuse of ecstacy most probably will lead to malfunctioning of neurons, but this is hard to measure and so people will still continue to believe that no matter how much X you take, youll be fine.

acid and weed wont cause brain -damage-, however, when your thoughts are exessively re-directed with drugs, the brain will start to develop in different ways, particularly when these drugs ar taken in adolescence. this brain development can be permanent, and with some brain types and genetic predispositions (which cant be detected really), this can lead to psychological diseases. in other people it can simply lead to eccentric or unusual personalities and thought patterns, but not damage to the physical brain.

one must remember however that when certain channels of the brian are opened up by drugs, the brain will try to develop more neurons on that 'channel' and eventually discard those channels that arent used. and so, when using any drug too much, it can lead to you brain merely being moulded around the use of the drug, and ability to think in terms of redundant things can deteriorate. for example, meth-heads can begin to see the world totally in measures of getting more meth, seeing other humans merely as tools or vehicles for meth, losing sense of love or compassion, since these deteriorate in favour of more accessable, instant rewards and motives of the drug.


most brain-damage?
solvents
(petrol, air-duster, glue fumes, turps, etc)That sums up the whole thread, right there. I would also like to point out that ecstacy, more often than not, contains either coke or heroin. It's been pointed out that heroin has very few detrimental effects on the brain except through withdrawal symptoms, and coke apparently prevents the reuptake of dopamine. So my question is, what are your thoughts on cocaine and heroin based ecstacy, bill?

[tumbledownDNA]

that was quite a perfect way to say it. i have questions too... concerning your concept of channels being built in your brain, when you take acid do you think its possible you build multiple new channels in your brain as opposed to one? ie every time you drink its relatively the same feeling, same with speed and coke.


i mean it would make sense to me that the "brain damage" caused by lsd is really just having too many channels opened in the mind. or not so much that even, but being convinced of a reality that is too different from society's reality to be compatable

[TopNotchStoner]

i mean it would make sense to me that the "brain damage" caused by lsd is really just having too many channels opened in the mind. or not so much that even, but being convinced of a reality that is too different from society's reality to be compatable
That is almost the exact definition of schizophrenia, which, as I'm sure you already know, cannot be caused by LSD but can be potentiated by LSD. Meaning that LSD can bring symptoms of a pre-existing schizophrenic disorder or other mental disorders to the surface. LSD has been proven to have absolutely zero negative effects on mental health when used with moderation and resposibility and without a family history of mental disorders and/or pre-existing mental disorders that the person ingesting the cid may already be experiencing.

[StonerBill]

yeh but we are talkin chronic use. i read some study somewhere that talked about people who had taken lots daily for over a year... they were normal functional people on teh outside but on the inside they portrayed some.. unusual.. traits lol. but only some of the chicks got violent, when they got nervous and threatened, they lashed out apparently. but thats pretty mild.

in terms of channels, its a very simplistic view, theres lots of differnet types of channels and they work in different ways, but it works for general discussion of drug influences on mind. alchohol however doesnt work on channel things at all, if anything it just shuts them down over chronic drinkning, leading to the memory problems alchoholics have thats much worse than stoners.

however, schizophenia is an actual disease, its just the method of classing people in mental disorders uses stupid systems like using definitions like those to somehow diagnose a physical disease. its a shortcut to the problems, damn psychiatrists

as for cocaine and heroin based ecstacy.. well then it wouldnt be much different to the effects of being seperate;) though taking lots of drugs at once does have worse effects on your brain than taking them seperately.

[tumbledownDNA]

alchohol however doesnt work on channel things at all, if anything it just shuts them down over chronic drinkning, leading to the memory problems alchoholics have thats much worse than stoners.



i don't know i would say it definitely opens up a new channel, which would be one through whcih unrealieased emotions/animal instincts are released. i mean i've seen friends blackouit, and when that happens its like they are a new person. no sense of reason, blabbering, uncontrollable anger and violence. i think blacking out is an example of switching totally to this channel, to a degree that one can't use his/her resources of mind to stop themselves. like this kid seriously major personality shift when he drinks its scary

[ImSpartacus]

Inhalents are for sure number one, second would be meth, third would probably be heroin, the others would be harder to judge in order.

[nesta]

heroin doesnt cause brain damage.

i dont know why opinion has anything to do with this issue. its not a matter of opinion, its a matter of what we have scientific evidence to support. there is not a grain of evidence to suggest opiates cause any kind of brain damage, so why would heroin even be on the list? heroin is actually a fairly safe drug if used in moderation, its the patterns and styles of use that are associated with heroin that are unsafe, and even then it doesnt cause brain damage.

[synaptic aether]

and so is nitrous oxide, which does alot of damage because of free-radicals, but their are vitamins one can take to help counter the damaging effects! hmm ... like, where do you get this from? a lot of things cause a lot of free-radical "damage" but i don't know why n2o is one that you really need to consider. i know it depletes b12 but it only becomes an issue with heavy users. i gather that with light use, it's not something you need to really even consider.

peee-uhe my boots smell funky!

[Eugene]

I don't konw if this counts, but using 'needle drugs' like herion, meth, or even cocaine puts you at a great risk for a bunch of disease, primarily AIDS that have a brain-wasting tendancy.
I voted for weed because no one else did, and I'm just like that.

[synaptic aether]

if you're worried about brain damage, stop eating Doritos like a fiend.

you know you do it.



http://www.truthinlabeling.org/Dang.html



haha oh god... i never thought of the ridicule that i could inflict upon anti-drug people thanks to msg.

[2cesarewild]

Ecstasy pills never contain heroin or coke. I guess people don't really know too much about the price of any of these drugs. Ecstasy pills are cut with stuff that is CHEAPER than ecstasy. Like ephedrine, ampthetamine, methamphetamine, caffeine, etc. This is how the underground drug market works, maximize profits any way you can because there is no agency controlling what is illegal in the first place.

Like nesta pointed out, heroin doesn't cause brain damage. In fact if you were a chemist extracting morphine and then making it into high purity heroin, and you didn't stop doing it, you'd have virtually no physical health problems. The only reasons needle drugs lead to spread of disease is because people use dirty needles, and most of the time people willing to use dirty needles to get high are the type of people who live dirty lives.

[nesta]

then you have the issues of using dirty needles, using impure heroin (as most users do), snorting will cause some physical problems as well...all sorts of things.

i've got to say that heroin interests me a lot, but i'm really unsure of how addictive it REALLY honestly is compared to other opiates, plus you never know how pure it is. i wouldnt want to take it with a needle or insufflate it either, the only way i'd do it would be orally. oral opiates are more than strong enough for me as it is. either way i'm scared of heroin even though i know its a rediculous stigma (well, sort of), and i've got an addictive personality and so on, and i wouldnt be able to accurately measure out an oral dose, so, no, i'm never going to do heroin.

but thats not to say the prospect of getting pure, pharmaceutical grade heroin pills wouldn't intrigue me, i know this is never going to happen though. anyway, its for the best that i not even try. but the only way i'd do opiates other than orally would be to smoke actual opium, and even there i've never gotten anything but fake opium, so i'd have to grow my own poppies, etc. etc.

anyway, yeah, opiates dont cause brain damage, but using them in an unsafe manner CAN cause other kinds of damage, and any addictive drug, when you lose control, can damage your life in nonphysical ways.

[TopNotchStoner]

[QUOTE=2cesarewild]Ecstasy pills never contain heroin or coke. I guess people don't really know too much about the price of any of these drugs. Ecstasy pills are cut with stuff that is CHEAPER than ecstasy. Like ephedrine, ampthetamine, methamphetamine, caffeine, etc. This is how the underground drug market works, maximize profits any way you can because there is no agency controlling what is illegal in the first place.QUOTE]
Ecstasy pills often contain either coke or heroin. I've seen many an ecstasy pill tested for various subtances with the respective testing kits. With the kits, the specific substances you are testing for will show up no matter how minimal the content happens to be.

[StonerBill]

yeh some people WANT other drugs in their E and thats how they get tehre. but heroin and coke could be acuired for cheaper than E? surely.. at least heroin lol

as for alchohol and the channels, no, when people balck out its because they simply have no control over their actions, they dont think things they wouldnt normally think subconciosusly, there is just less of a buffer between conscious and unconscious thoughts directing flow. this is where the whole idea of channels in teh brain goes askew when you dont take into account whats actually going on

[psychoactive321]

stupid inhalents u find in ur garage are the worst.. ive done alot of drugs alot of which people look down upon like crack for instance.. but i wouldnt touch inhalents but if someone threw a rock at me at id have to contemplate a little bit. inhalents are just dumb and it sucks for kids that dont have access to pot and mushrooms.. things that kids should be experimenting w/ and have to resort to inhalents or or there moms otc medicinces like coriciden

[nesta]

so are you on crack now? because it would appear you can't even muster up the capability to form coherent sentences.

[psychoactive321]

so are you on crack now? because it would appear you can't even muster up the capability to form coherent sentences.
Well no i havn't smoked crack in quite some time, so i guess that can't be the reason for my incoherent sentences. Apparently the only justification i have for that is simply my own stupidity, which i am sorry if it offended you. Next time I guess it would be who of me to "muster" up a little more literacy for your sake.

[tumbledownDNA]

Next time I guess it would be who of me to "muster" up a little more literacy for your sake.
be who of me?

[2cesarewild]

The only reason people think heroin is cheap is because you only hear about garbage black tar. Raw heroin costs a serious amount of dough, as something like 10 mg's will fuck you up. Dime bags of trash have a lot more in them than dime bags of raw stuff. So you cut it and sell it to junkies and make a hell of a lot of money. Rolls are 5 dollars a pop here I mean, come on. They are not cut with heroin or coke, it is a myth. To the poster above saying he finds lots of pills cut with h or coke, sounds like complete bullshit to me. What prints were they? What part of the country did this happen in?

[TopNotchStoner]

The only reason people think heroin is cheap is because you only hear about garbage black tar. Raw heroin costs a serious amount of dough, as something like 10 mg's will fuck you up. Dime bags of trash have a lot more in them than dime bags of raw stuff. So you cut it and sell it to junkies and make a hell of a lot of money. Rolls are 5 dollars a pop here I mean, come on. They are not cut with heroin or coke, it is a myth. To the poster above saying he finds lots of pills cut with h or coke, sounds like complete bullshit to me. What prints were they? What part of the country did this happen in?
There were some Mitsubishi rolls going around Geaorgia last year that contained heroin and recently there have been some triple stack Superman rolls that contain coke. There were a few others but can't remember their names. I have have only recently had my first experience with ecstasy, but I hang out with people who have been rolling for years.

[StonerBill]

rolls cost at least 20 dollars here, and anythin of proper quality over 30. if it was bein sold for less than 20, i would be vvvvvery suspicious. i wish drugs were as cheap as they were in the us!

[nesta]

most good rolls here cost at least 20-30 USD unless you buy in bulk

[2cesarewild]

most good rolls here cost at least 20-30 USD unless you buy in bulkThat sucks man I'd say try to find a new dealer though (if you're even interested in rolls but I don't think I've seen you talk about them too too much anyways), SWIM told me they're still 5-6 USD all over the place here after a recent bust of the biggest supplier with 150k of his pills. Every print that's around is that much even if you buy a single it's only ten bucks. People get laughed at trying to sell em for any higher usually. IDK E is shite to me, it's all over the place, it's not that fun, and the whole E destroying the L market bites my arse too lol... Regardless, someone in your area is getting those rolls real cheap, and if you look hard enough you might be able to find that person.

[TopNotchStoner]

I've only rolled one time, they were triple stack Green Nikes and they were $12 each.

[2cesarewild]

"Triple Stack" is a marketing ploy. But anyways, you took two or what? The first time is always sick, but every time after that just gets more and more weird and less fun if you ask me.

[synaptic aether]

n/m

[TopNotchStoner]

"Triple Stack" is a marketing ploy. But anyways, you took two or what? The first time is always sick, but every time after that just gets more and more weird and less fun if you ask me.I took 2.5 triple stacks and rolled my ass off for at least 10 hours.

[seancourt]

one time i took 7 rolls, and i rolled so fucking hard, i don't do EX very often though, maybe once every couple months, it's a nice treat for a nice weekend :-)

[nesta]

its not a matter of me finding a new dealer, caesar, its just the market price in this area. i'm not too interested in ecstacy at all, but plenty of my friends are, and i have done it a few times. however, EVERYONE i know who rolls, EVERYONE i've ever met trying to sell rolls, and so on....ALL my experience would lead me to believe that around here if you want a decent roll you're going to be expecting to pay at least about 20 bucks. you can get rolls for less, but not often and not good rolls.

its what people EXPECT to pay, its what people DO pay all the time, and its what is asked of you to pay unless you buy in larger quantities. theres no getting around it, i'm simply not likely to find a 10 dollar roll, and i am really not too interested in finding one anyway. you say a dealer would be laughed at where you are trying to sell a roll for more than 10 bucks...well here, you may well get laughed at for trying to BUY a roll for less than 15....if i dont want to pay that, theres scores of willing potential customers who will pay that type of price.

[pansy]

..

[Antimatter235]

yeah alcohol. it's not just neurotoxic it's just plain toxic, which means every single cell is damaged and some hormones too. whether you abuse it or not.
a couple bumps of meth and a good diet after the high isn't toxic at all. but binging is another thing (not eating, not sleeping, etc).

[firelip]

Meth has the best documented long-term damaging effects on the brain of commonly abused drugs. It fucks with the dopamine receptors and causes bipolar disorder that lasts for months to years after the subject quits the drug. Probably the next worst is ethanol.

Jim

[lost in smoke]

id have to say cannabis is a pretty nasty drug for some people after a wile (not smokin at the mo due to winter depression + weed being the most suck ass mixture known to me)

[lostcause]

I would have to think ether is a pretty bad one. That or oxygen. People that shove a bicycle pump up their ass to get high are fucked up.

[Mordiana]

Well, alcohol only damages in overuse, weed doesn't do any permanent damage, your brain comes back after you quit, the reason it doesn't seem so is because it stays after heavy use for up to a month in your system.

I chose heroin, for its the most addictive.
Inhalants are bad, they do a lot of damage too (I saw that on people)
Crack and cocaine do a lot of body damage, they're the worst for your body, so I guess I could have chosen that onces too.
And xtc, if taking more then 50 pills in two years; destroys some receptors in your brain, not exactely sure about that since I didn't study this (yet).

[firelip]

X does not destroy receptors, that was a bogus study that has been retracted. What they proved was that meth destroyed dopamine receptors leading to potentially increased risk of Parkinson's disease. For much the same reason, meth induces bipolar disorder.
X is a bit hard on the body, and it depletes your seratonin, but within a few days, all brain chemistry should return to normal.

Jim

[BannedInDC]

Meth, that stuff scares the shit out of me

[illuminati boy]

ALCOHOL: Probably causes some of the most notable physical changes in the brain out of the list above. A good starting reference might be found here: http://apt.allenpress.com/aptonline/?request=get-abstract&issn=0022-3069&volume=057&issue=02&page=0101 (http://apt.allenpress.com/aptonline/?request=get-abstract&issn=0022-3069&volume=057&issue=02&page=0101)



WEED (AKA Marijuana): Appears to have some impact on short-term memory and motivation. There have long been rumors of a link between marijuana and psychosis, but the causation is unclear (i.e. does marijuana ‘cause’ mental illness, or do persons with a mental illness ‘self-medicate’ with what is readily available). Here is an older article that seems to indicate that brain damage has yet to be proved: http://pharmrev.aspetjournals.org/cgi/content/abstract/38/1/1 (http://pharmrev.aspetjournals.org/cgi/content/abstract/38/1/1) Have not seen specific data on marijuana causing ‘brain damage’ par se apart from this: http://www.timesonline.co.uk/article/0,,2087-1920069,00.html (http://www.timesonline.co.uk/article/0,,2087-1920069,00.html) … in fact have seen some articles indicating a possible neuroprotective role for some of the cannabinoids http://www.erowid.org/plants/cannabis/cannabis_journal.shtml#neuroprotect (http://www.erowid.org/plants/cannabis/cannabis_journal.shtml#neuroprotect)



X (AKA MDMA): The verdict on whether ‘ecstasy’ brain damage is still out. MDMA certainly causes brain changes, but so far the evidence that this writer has seen indicates that the changes in serotonin functioning for occasional use are similar to those from say Prozac… in that they will revert to ‘normal’ after a period of time (i.e. temporary brain change no brain damage). The only studies to show actual brain damage were either retracted because the numb nuts research used megadoses of methamphetamine by ‘mistake’ or they were retrospective studies of poly-drug users and causation could not be rightfully inferred. Certainly there is an overdose risk with MDMA, but whether moderate use or therapeutic use poses a danger to cognition really is an open question. Beware though; MDA, PMA, and several other compounds that are commonly found in pills called ‘ecstasy’ these days could likely cause neuronal damage.



METHAMPHETAMINE: Bad stuff. Don’t follow the literature on this one as much. In my anecdotal experience bad stuff. Would guess that it is neurotoxic at large levels for certain as in the MDMA study that claimed clear brain damage it was methamphetamine they gave their animals by mistake. Google yielded this: http://www.kci.org/meth_info/sites/reuters_032700.htm (http://www.kci.org/meth_info/sites/reuters_032700.htm) I am not sure about low-dose methamphetamine use though. A little known fact is that methamphetamine is used in the US and elsewhere as a Rx medication for the treatment of severe ADD or obesity. Would guess that it is not drastically neurotoxic at low levels or it probably would not be available as a Rx. But again this is not an area of research that I am very familiar with.



ACID (AKA LSD): Not really aware of any indication that LSD causes any type of brain damage in recreational doses. It certainly has the ability to elicit flashbacks, so in certain persons under certain conditions, it certainly is capable of causing brain changes. Would guess that if used with appropriate precautions there is minimal concern with regard to physical safety. Albert Hoffman the first human to ingest LSD will be turning 100 in January and he has still been fairly active in recent years. Many of the other early researchers to investigate LSD (sometimes taking hundreds of thousands of doses over the course of their life) are still around and mentally and physically active into their 80’s or later. Would say that this is pretty good anecdotal evidence against any sort of serious long-term concerns related to cognition.



HEROINE: Not as familiar with the specifics here. Do know that heroine users usually take years before they become involved in the criminal justice system etc. It is possible to be a really high-functioning maintenance user. What the longer-term consequences of heroine use are may be unclear. Just browsed a few anti-drug websites and none of them mentioned ‘brain damage.’ One mentioned “poor concentration” but this was under their description of acute effects. This is not to minimize the physical dangers of use, unsafe needle practices, etc.; but from what I have found, neurocognitive deterioration is not high on the list of concerns (though again there are certainly others).



COCAINE: There are quite a number of studies showing a wide range of negative effects from cocaine. This one is from just the other day: http://www.sciencedaily.com/releases/2005/12/051214084800.htm (http://www.sciencedaily.com/releases/2005/12/051214084800.htm) this one is from a few years back at BBC: http://news.bbc.co.uk/2/hi/uk_news/scotland/3503931.stm (http://news.bbc.co.uk/2/hi/uk_news/scotland/3503931.stm) Cocaine is probably pretty bad stuff to use regularly. Not very brain or learning friendly (in addition physical health risks of course).



NITROUS OXIDE: There is little evidence that nitrous oxide causes any brain damage by itself (in commonly used amounts). It DOES NOT displace oxygen and can be coadministrated with pure oxygen as when it is used by your local dentist. So if you were breathing say a 70/30 or 80/20 mix of nitrous oxide you could probably do so for quite a while. The main risks of nitrous use are related to 1) Hypoxia and 2) B12 deficiency resulting in neuropathy. Let me break that down. Hypoxia, or lack of oxygen, can indeed cause brain damage. This is fairly easily remedied by breathing oxygen along with the nitrous oxide in sufficient quantity to allow for normal cell respiration. B12 deficiency is caused by a the nitrous oxide interfering with the bioavailability of the vitamin. Preloading with B12 and methionine will likely reduce this risk. It is not something that should be taken lightly if you are using nitrous on a fairly regular basis as some persons have developed severe neuropathy (nerve damage) resulting in tingling, loss of feeling, and some inability to control muscles. But again it is a risk that is fairly easily reduced by vitamin and methionine pre and post loading. An interesting overview of nitrous oxide can be found here: http://www.tripzine.com/print.asp?id=nitrous-gnosis (http://www.tripzine.com/print.asp?id=nitrous-gnosis)



DXM: There has been some discussion of Olney’s Lesions in relation to DXM, but this is quite questionable. Even should DXM be found to possibly cause Olney’s Lesions, there is not any evidence at present that this leads to practical behavioral of cognitive effects. If you really are concerned about this you can look at this and other articles at Erowid on the debate: http://www.erowid.org/chemicals/dxm/dxm_health2.shtml (http://www.erowid.org/chemicals/dxm/dxm_health2.shtml)

Certainly there has been no indication of brain damage from DXM when used as a cough suppressant so far as I am aware.



Ok this was rather long but hope it addresses the initial question in this topic.



I B

[MistyMountainTop]

DX-to the muthfuckin-M yo! That shit is terrible for your brain. That's what made me permanantley insane. Meth, cocaine, crack cocaine (you forgot ritalin, dexedrine, adderall, etc. that shit has the same effects on neurochemistry as meth and cocaine). Inhalants-major damage. Heroin, lots of damage. Ecstacy DOES do major brain damage. It messes up the brain's ability to release the neurotransmittor seratonin. Alcohol will only damage the brain in high doses. A few glasses of wine is actually good for the brain. Weed doesn't do any damage at all. And mushrooms are good for the brain, cause they have small amounts of penicilin in them that helps protect against diseases, including brain disease. And LSD. Gimme a break man. WHy's that even on your list? No damage at all. That stuff enhances the soul, and will "Take The mind to places where minds don't usually go". LSD freed my mind man.

[adrian nor]

lsd does not cause brain damage and DXM realy isnt studyed enough but it does cause brain damage,E as far as i know doesnt casue any brain damage,neither does heroin,N2O,or marijuana,you should realy fix your list man most of the drug on it dont damage the brain,but i would have to say meth,PCP,crack/cocaine, inhalents are by far the worst be it depends on what ones your talking about N2O doesnt cause damage and ether realy isnt that bad it was used by doctors for a long time
Yup. X can lower your brains production of serotonin and generally give you a life-time ANTI-X... http://www.hipforums.com/forums/images/smilies/humm.gif

Opiates: Not damaging. VERY addictive. Can O.D. from
N2O: Too little vitamin B12
Glue: Glue is meant to glue things together. If you huff glue, go figure what happens inside of your brain!! Go, buy some weed!
Weed: You may get SHORT-term stupid and "slow"
Alcohol: Brain-damage and STUPID behaviour. Don't do it too much!

Overall:
My favourites: Nitrous, weed, opium(http://www.hipforums.com/forums/images/smilies/embarassed.gif)

Be careful with opiates. They can and will fuck alot of people up!
Nitrous feels pretty HEALTHY actually! Opium same thing, just not as healthy and clean feeling. Weed feels a little more "slow", but is still GOOD AS HEAVEN!

[digital 3.0]

Life is the biggest trip of all, drugs in general are fucked up, so are car accidents, tramas, drama, stress and smoking, being sick, medication, hospitals and street life in general.

X doesn't cause holes in your brain
DXM who really know
Alcohol withdrawls can kill you
Opioids can stop your breathing and heart
Meth can make you test your endurance and make you think your so super until you find out your just about dead
LSD can do all kinds of stupid shit, and send you into an emotional barricade from reality for a long time

Were all on different levels, spiritually mentally, emotionally, physically
What can I really say, lifes a trip, and when you trip inside of life it makes the world spin a different way. Good or bad, or even if theres such a thing I would say that personally deep down drugs are a spiritual thing.

[sugarmagnolia590]

i think crack kills your brain more because some people that are on crack really cant think right and when they dont have any they get all weird and shit

[mushie18]

Life is the biggest trip of all, drugs in general are fucked up, so are car accidents, tramas, drama, stress and smoking, being sick, medication, hospitals and street life in general.

X doesn't cause holes in your brain
DXM who really know
Alcohol withdrawls can kill you
Opioids can stop your breathing and heart
Meth can make you test your endurance and make you think your so super until you find out your just about dead
LSD can do all kinds of stupid shit, and send you into an emotional barricade from reality for a long time

Were all on different levels, spiritually mentally, emotionally, physically
What can I really say, lifes a trip, and when you trip inside of life it makes the world spin a different way. Good or bad, or even if theres such a thing I would say that personally deep down drugs are a spiritual thing.
well said.

[PurpleGel]

MDMA: actually, MDMA does damage your brain. taking a few doses is fine (much like anything in moderation), but chronic, heavy X users have very significant cognitive problems involving, but not limited to, problems with decision making, decreased attention, increased impulsivity, paranoia, etc.

someone mentioned that the studies on MDMA are bullshit, but this is not the case in 2006. X is believed to cause most of its damage by the selective degeneration of serotonin axons, nerve terminals, and reuptake transporter proteins (especially in the cerebral cortex and hippocampus). you can google this stuff and find your own references (i don't have my articles and texts on me right now).

COKE/METH: all of the amphetamine-type drugs (meth, cocaine, etc) cause brain damage after repeated, especially heavy, use. cocaine and crack are not as different as people have made them out to be in the polls; it's a matter of snorting versus smoking the drug... anyway, everyone has heard of amphetamine-induced psychosis. it's real.

ALCOHOL: alcohol causes brain damage, especially in heavy, chronic use. however, i would say that it causes brain damage on every use, since it obviously depresses neurons to the point of death and it handicaps hippocampal neurogenesis (basically, new neurons are born dysfunctional and remain dysfunctional after their migration).

OPIATES: i've never read about them causing brain damage. i agree with nesta and 2cesarewild. opiates can do lots of horrible things to you in certain circumstances, but this thread is about brain damage, not addiction, withdrawal, or overdosing.

WEED: i can't believe someone chose weed as the drug that causes the most brain damage. this is just a result of misinformation or simple ignorance. weed is the safest drug on the list.

i don't know a lot about inhalants but i know they're harmful. doing them is obviously stupid. including nitrous oxide in this category, however, is not really fair. nitrous is not the same as freon or industrial solvents. nitrous, as far as i know, is relatively safe, at least in mild/moderate administration like at the dentist's office. the only problem is when taking nitrous in large doses to get a strong 30-second high. some people may not take in enough oxygen, which can be damaging to the brain. but that's not the nitrous--that's the user. it does affect B-12, but i don't think this is significant unless you're getting high on nitrous everyday.

over all, i think the poll is on the right track: meth, cocaine/crack, and alcohol are the highest, excluding the inhalants category which is unclear.

peace.

[polymer]

cocaine and meth alter brain chemistry but don't necessarily "damage" the brain with even moderate use.
*nods @ StonerBill* Inhalants are solvents, and do more damage, especially the fat soluble, non-polar ones like toluene and benzene. alcohol is also a solvent, which has been shown through PET/CAT scans to shrink the brain inward (the outer part of the brain is GABA-laden, which ethanol modulates), but this occurs after years of heavy use.

MDMA has been shown to erode axon sheaths by oxidation, but no holes in the brain. Even the "olney Lesion" hypothesis of dissociatives like PCP, DXM, and Ketamine is inconclusive.

the really damaging drug isn't listed, it's MPTP; a very neurotoxic by-product of incomplete meperidine synthesis. One dose may be enough to produce irreversible parkinsonian-like symptoms; it actually kills dopamine receptors by free-radical oxidation.

out of the ones listed, inhalants for sure. nitrous oxide shouldn't even be listed as an inhalant, it's relatively benign in comparison.

[MeatWagon499]

meth, then crack, then coke, then dxm, then X,

acid does not cause brain damage whoever voted acid is a dumb mother fucker

nitrous is the only inhalant that does not cause brain damage, how funny
but all the other ones fuck you up hardcore

chemicals man, they'll FUCK you up

[WanderingSoul]

Pot does NOT kill brain cells. That is a myth. Pot makes you smarter. Even though it messes up your short term memory, it makes your long term better. It can even dredge up old memories. A new study shows that it makes your long term function longer, which prevents alzheimers. It does not contain the same carcinogens and tars as tobacco. That's a lie, too. Smoking it is actually good for your lungs, and it helps asthmatics breathe better. Let's just face it: pot is GOOD for you. It's like medicine that makes you feel good. Stick with pot. It's just healthier.

[PurpleGel]

careful; that appeal is a bit misrepresented....

[WanderingSoul]

What do you mean? I have no idea what you're talking about.

[Shaman420]

inhalents then meth.

[Eeso]

Polymer hit on this in his last post.
In the context of the question - how do you define "damage"?
Remember that we're talking specifically about damage to the brain as an organ. Not damage to a persons psyce.

And as someone else said - it's not really a matter of opinion, it's about science and evidence.

There's alot of bullshit floating around this thread sadly, though I must say there's a few here that have their science hats on.
kudos

[Shaman420]

Damage to your brain: inhalents minus nitrous oxide are the worst. That is a fact. The high you get from huffing is your brain cells being slaughtered.

2nd worst... amphetamines.. in comparison to everything else there is too much of a toll on your body specifically your brain because of the side affects alone (chronic insomnia, poor appetite, etc.) much less the fact that most amphetamines are nuerotoxins.

[Eeso]

Yea inhalants are probably on the top of 'the list'

But not all amphetamines have been shown to be neurotoxic, and said neurotoxic effects have been shown to be in most cases at least partially reversible.

[WanderingSoul]

Polymer hit on this in his last post.
In the context of the question - how do you define "damage"?
Remember that we're talking specifically about damage to the brain as an organ. Not damage to a persons psyce.

And as someone else said - it's not really a matter of opinion, it's about science and evidence.
I agree

[Duck]

I would say meth and inhalants

but it's hard to say, it's all so variable
how much do you use? how often?

hard to compare fairly

[Duck]

whoever said weed needs smacked

[MeatWagon499]

fuck i did meth last night :(

[UXnIHAOnUXbmUXn]

meth and alcohol do the most direct damage IMO.

cocaine and ecstasy can also fuck up your head if you stay on them for an extended period.

[moe.ron]

e in no way shape or form will ever put a hole in someones brain..ignorance about drugs really pisses me off..but anyways yea probably inhalents..i mean cleaning solvents wtf! no one gets high off of them, all they do is cut off the oxygen to your brain.DXM and meth are really bad too

[Echelon]

Jimson weed is bad, but that wasn't a choice so I picked "nitrous oxide (inhalants)". And to all the people that picked DXM, where's the evidence that it fucks up your brain? Many of my friends and I have done massive amounts of DXM and we didn't end up like Terri Schiavo.

[Eeso]

yea nitrous shouldn't' be lumped in with ''inhalants"

[Duck]

yea nitrous shouldn't' be lumped in with ''inhalants"why not? it's an inhalant...

[Eeso]

true, but usually "inhalants" is used to refer to such things as propane, gasoline, starter fluid (benzine/ether) and the like.

Nitrous is an exception. The only known adverse affects from such is a depletion of vitamin b12 and a decrese in the methioine synthesis process.

[Duck]

true, but usually "inhalants" is used to refer to such things as propane, gasoline, starter fluid (benzine/ether) and the like.

Nitrous is an exception. The only known adverse affects from such is a depletion of vitamin b12 and a decrese in the methioine synthesis process.HAH
I've heard much worse things about it
and whether that was propoganda or not (which I doubt in this case) it is still known (just not necessarily known correctly :tongue: )

from what I understand/have seen, that shit makes you drop brain cells worse than when your mom smoked crack with you kicking inside of her

[moe.ron]

DXM caused olneys lesions http://www.erowid.org/chemicals/dxm/dxm_health1.shtml disociatives really fuck with your head.

[Eeso]

There is no published evidence currently to support the theory that Olney's Lesions can occur in humans.

What have you heard about N2O?

Definitions of known; on the Web:

apprehended with certainty; a known quantity; the limits of the known world; ;a musician known throughout the world...
wordnet.princeton.edu/perl/webwn

the Force of science, reason, and the rational world. Governed by Mercury, Patron of Discovery.
woodelf.dyndns.org/alfresco/gloss.html (http://www.google.com/url?sa=X&start=1&oi=define&q=http://woodelf.dyndns.org/alfresco/gloss.html&usg=__KdmgzxDjz-9ci259g5Ooa1FUja0=)

[ergotoxine]

I picked alchohol, but I suppose inhalants are just as bad.
As far as brain damage goes-
Heroin will not cause any unless you overdose and lose oxygen to the brain.
LSD, mushrooms, etc.. do not cause any brain damage (technically) although they affect the chemical balances in the brain and this can fuck you up.

[kidsmoke]

Dissociatives in general are the worst as far as brain damage goes. PCP being the worst, ketamine being the 'best' and DXM being somewhere in the middle. Nitrous is technically in that category too, but I'm not sure how it ranks in there.

[iThroPooAtYou]

first inhalents
then dxm, nitrous (most dissassoc. are suspected of causing physical brain damage, though there is debate if this damage is organic, and if the brain can heal from it)

I don't know that other's like meth, crack, heroine cause physical 'brain damage', but they definitely cause psychological problems

[uplink]

#1: Inhalants (Aerosol, Glue, Lighter Fluid, Paint Thinner etc. NOT NITROUS!)
#2: Deliriants (datura, belladonna, benedryll, nutmeg and antihistamines)
#3: Methamphetamine / Crack Cocaine
#4: Heroin

In Peru glue is the drug of choice because it's cheap and it takes away the hunger pains (they are all starving).

[BeaverKoffi]

lol.... UPLINK where did u hear that datura causes brain damage lol ?? even more harmful than crack or heroin LOL.... and these people even give advices....

[supahdude]

id say X

i got HPPD from X after 5 uses.

i <3 lsd and pot

[WayfaringStranger]

i took a diferent approach. although heroin dosent really kill as many cells in the brain, i think it changes your whole personality more drastically than any other. maybe not outwardly as noticeable, but your motivations and values are changed the most drasticaly for the longest amount of time. sure most of the others will burn a cavern in your brain faster and more noticably,but i voted heroin.

[WhisperingWoods]

Hahah if you think nitrous does so much brain damage, you better never get a cavity.

[uplink]

lol.... UPLINK where did u hear that datura causes brain damage lol ?? even more harmful than crack or heroin LOL.... and these people even give advices....Actually it does... and worse.

I found this warning about atropine online:

DIPHENOXYLATE HCl AND ATROPINE SULFATE IS NOT AN INNOCUOUS DRUG AND DOSAGE RECOMMENDATIONS SHOULD BE STRICTLY ADHERED TO, ESPECIALLY IN CHILDREN. DIPHENOXYLATE HCl AND ATROPINE SULFATE IS NOT RECOMMENDED FOR CHILDREN UNDER 2 YEARS OF AGE. OVERDOSAGE MAY RESULT IN SEVERE RESPIRATORY DEPRESSION AND COMA, POSSIBLY LEADING TO PERMANENT BRAIN DAMAGE OR DEATH (SEE OVERDOSAGE). THEREFORE, KEEP THIS MEDICATION OUT OF THE REACH OF CHILDREN. THE USE OF DIPHENOXYLATE HCl AND ATROPINE SULFATE SHOULD BE ACCOMPANIED BY APPROPRIATE FLUID AND ELECTROLYTE THERAPY, WHEN INDICATED. IF SEVERE DEHYDRATION OR ELECTROLYTE IMBALANCE IS PRESENT, DIPHENOXYLATE HCl AND ATROPINE SULFATE SHOULD BE WITHHELD UNTIL APPROPRIATE CORRECTIVE THERAPY HAS BEEN INITIATED. DRUG-INDUCED INHIBITION OF PERISTALSIS MAY RESULT IN FLUID RETENTION IN THE INTESTINE, WHICH MAY FURTHER AGGRAVATE DEHYDRATION AND ELECTROLYTE IMBALANCE.

DIPHENOXYLATE HCl AND ATROPINE SULFATE SHOULD BE USED WITH SPECIAL CAUTION IN YOUNG CHILDREN BECAUSE THIS AGE GROUP MAY BE PREDISPOSED TO DELAY DIPHENOXYLATE TOXICITY AND BECAUSE OF THE GREATER VARIABILITY OF RESPONSE IN THIS AGE GROUP.

[Geneity]

Datura contains poison. You aren't tripping of off psychoactive compounds you're tripping off poison. Such a horrible plant. Why did people ever start using this recreationally.

I personally think Inhalants are far more dangerous then street drugs. Inhalants are simply suffocating yourself and destroying sensory receptors to get high. The chemistry behind things used as inhalants isn't pretty. Computer Duster can do a hell of a lot of damage, and can kill you because you're too stupid to know when to stop. Nitrous is generally harmless though, as long as you aren't binging. If you use it a lot though, it's highly suggested you take multivitamins or B12 complex because it depletes B12 pretty bad.

I thought Meth was more physically damaging then mentally. Sure the cravings can cause someone to be pretty insane, but that isn't destruction of your brain. Meth binges, however, can produce serious mental damage. Like Amphetamine Psychosis and just really horrible things in general.

Heroin can change someone's personality because of the extreme depletion of Seretonin in the brain, but I don't think thats permanent, although it can take years to heal.

Acid, I think, can cause psychological damage, but whether or not any of that is because of physical brain damage is beyond me.

I voted DXM because high doses have been proven to make tiny scars on the brain. Dissociatives in general are highly dangerous to the brain. I think enough DXM usage can severely and forever damage one's brain. I've noticed my temper is much worse and easier to trigger since I started heavily using DXM. I've cut it down to only using once a month or so.

[StayLoose1011]

Oh my God, the amount of misinformation in this thread is absurd... I don't have time to post about now, but until I do, people, please don't believe anything on here, because a ton of it is pulled out of someone's ass.

[Geneity]

Oh my God, the amount of misinformation in this thread is absurd... I don't have time to post about now, but until I do, people, please don't believe anything on here, because a ton of it is pulled out of someone's ass.I don't think mine is =(

[Peacey]

meth messes you up bad i heard

[archduke]

Aerosol, gasoline, other inhalents in general do a lot more than any of those.

As far as Ecstasy putting holes in your brain...
http://thedea.org/neurotoxicity.html#holes

[PsychMyke]

[QUOTE=2cesarewild]Ecstasy pills never contain heroin or coke. I guess people don't really know too much about the price of any of these drugs. Ecstasy pills are cut with stuff that is CHEAPER than ecstasy. Like ephedrine, ampthetamine, methamphetamine, caffeine, etc. This is how the underground drug market works, maximize profits any way you can because there is no agency controlling what is illegal in the first place.QUOTE]
Ecstasy pills often contain either coke or heroin. I've seen many an ecstasy pill tested for various subtances with the respective testing kits. With the kits, the specific substances you are testing for will show up no matter how minimal the content happens to be.
thats wrong dude...ive eaten hundreds of e pills and i have never ever seen it, all my beans were tested except a very select few...nor has my roll tard friend seen it whos eaten over a thousand beans who owned the testing kit who sold me all the beans ive ever eaten. They never contain coke or heroin...ever, people need to get that straight, it's a MYTH, it makes no sense...

People think that because the roll is dopey it has heroin....nope....pure mdma is dopey as fuck, very mellow, very chill and trippy as hell....the more slow and dopey they are, the more pure they are...doesnt mean they have heroin in them. Do you know how many people would die if heroin were in E pills. Its like speedballing..E is a psychostimulant. Not only is your brain loaded with serotonin, but your heart is racin because it releases dopamine just like coke and just like meth (not to the extent meth does tho)

People think that because a roll is speedy it has coke...wrong...that would defeat the purpose of cutting it, why wouldnt they just add all mdma, coke is worth much more then mdma...plus the amount of coke you could fit in a pill with a good amount of mdma and fillers would get you high for 45 minutes....an hour tops....speedyness in beans is meth, and other cheap stimulants...usually meth because the high lasts for hours as opposed to minutes....

there are NO heroin or coke is street pills...im not saying that there arnt rare cases were it hasnt happened...obviously the myth originated from some fact...but its so rare i garentee no one in here has ever seen it with a tester with there own eyes...if you have then lemmie know...but its been proven time and time again its a myth. Ironically enough people who support the myth have eaten like 10 rolls in their entire life and think they are experts on the subject


On the subject of my roll tard friend whos eaten over a thousand....when you abuse E like that...its BY FAR the most harmful drug....hes fucked for life, i watched his mental state deteriorate and no one could slow down his use no matter who tried to intervene...its was a horrible thing to witness. He can hardly read anymore. At least with meth, your brain recovers from the damage, E fucks you for life.

[PsychMyke]

Pot does NOT kill brain cells. That is a myth. Pot makes you smarter. Even though it messes up your short term memory, it makes your long term better. It can even dredge up old memories. A new study shows that it makes your long term function longer, which prevents alzheimers. It does not contain the same carcinogens and tars as tobacco. That's a lie, too. Smoking it is actually good for your lungs, and it helps asthmatics breathe better. Let's just face it: pot is GOOD for you. It's like medicine that makes you feel good. Stick with pot. It's just healthier.are you serious bro...

when i was smoking i was blazing a quarter a day and my lungs were sooooo fucked up. I was coughing up chunks of black, even spots of blood at one point. I was hawkin up phlem all day for years. And Ive never smoked cigarettes. While weed doesnt have as many carcinogens like cigarettes, it contains about 5x the tar that tobacco has. And weed doesnt make you smarter...it does prevent alzheimers but your glamorizing the effect like theres no tomorrow. Preventing alzheimers has nothing to do with gaining intelligence. People who smoke weed chronically have a horrible short term memory and they are slow on the draw mentally, they have no motivation and they eat way too much food. Not like thats a bad thing, i was a pothead for a long time, and its great...i love weed. But saying its HEALTHY is stretchin it man. It might be safe in drug standards, but its definatly not healthy. Eating vegetables is healthy...blazing weed all day is not.

[HoodHop]

nitrous oxide (inhalants)

[seanydizzle]

are you serious bro...

when i was smoking i was blazing a quarter a day and my lungs were sooooo fucked up. I was coughing up chunks of black, even spots of blood at one point. I was hawkin up phlem all day for years. And Ive never smoked cigarettes. While weed doesnt have as many carcinogens like cigarettes, it contains about 5x the tar that tobacco has. And weed doesnt make you smarter...it does prevent alzheimers but your glamorizing the effect like theres no tomorrow. Preventing alzheimers has nothing to do with gaining intelligence. People who smoke weed chronically have a horrible short term memory and they are slow on the draw mentally, they have no motivation and they eat way too much food. Not like thats a bad thing, i was a pothead for a long time, and its great...i love weed. But saying its HEALTHY is stretchin it man. It might be safe in drug standards, but its definatly not healthy. Eating vegetables is healthy...blazing weed all day is not.

smoking weed on occasion actually does help with asthma, i used to be asthmetic, but ever since i started smoking once or twice a month it went away (and it still away even though i dont smoke anymore). on top of that, my grandma used to give my aunt weed when she was aobut 6 because she had asthma, it cleared up (that was advice from her doctor). as for smoking it everyday, its obviously going to mess up your lungs.

[mr.mescalito]

I dont like this poll, you shouldn't of put *nitrous oxide (inhalants)*, now people get the image that nitrous causes brain damage. Nitrous is very harmless if you take it smartly and don't keep a mask strapped around your face or forget to breathe oxygen. The only reason it can be considered harmful is for people who take about a can of canisters per day because it'll create a B12 deficit. Other than that, its all about abuse.
If you consider this poll , "which of these drugs, taken only ONCE, causes the most brain damage?" I would say LSD, not for physical brain damage, but mostly for intense change in psychological perception, if physical brain damage, probably meth.

[freediver]

I'm not sure why meth gets such a bad name seeing as how its a VERY close analogue of amphetamine(adderoll) and probably exerts itself in almost the exact mechanism. sure if u take a high dose that can cause damage maybe as can tons of legal prescrip drugs. and street shit has so many carcinogens, very acidic contents, and harmful byproducts from makers that these things are probably a big source. I have never touched the shit but just saying.\

Exatacy given in high doeses to rats was show to cause changes in the neurons shape not sure if this was while still on the drug or long afterward. But these changes we not observed in the same doses when mdma was followed with prozac. Once again all the impurities in mdma tabs are whats making studies on "xtc" users brains not representative.

The sad truth is that we don't know alot about drug effects on our brains. With the technology we have nowdays we could know alot more if studies get done but nobody does, probably because it will come out that certain drugs don't cause any problems

[Share the Warmth]

Weed is one of the safest drugs you can put in you. Safer than aspirin. A HUNDRED times safer than alcohol, which you can actually overdose on and quite easily too.

Anyone who tells you that pot will damage your brain is trying to scare you. Why? Because the system wants them to. And why does the system want people afraid of pot?

Because people who smoke pot have a better chance of realizing what a crock of shit all of this is. The system would prefer for you to drink booze and smoke cigarettes. Keeps you satiated, dumb, and weak.

[otb01]

A tie between meth, coke and crack.

[otb01]

Btw, that pill testing website has found pills with coke. http://www.ecstasydata.org/results.php?A=SearchAll&Start=0&S=cocaine&OldSort=DTD&NewSort=&SField=Substance

5 to be precise.

And one with Heroin

http://www.ecstasydata.org/results.php?A=SearchAll&Start=0&S=heroin&OldSort=DTD&NewSort=&SField=Substance

Two with fentanyl

http://www.ecstasydata.org/results.php?A=SearchAll&Start=0&S=fentanyl&OldSort=DTD&NewSort=&SField=Substance

Ex is cut a lot of the time. Btw, testing with a reagent doesn't always prove that there arent impurities. Even dancesafe says that just because the reagent will give a positive for MDMA it does not mean that there isnt any other stuff in there.

[Lecarick]

Brain damage with X is not as profound as people think. However, the damage that does occur happens when your body runs out of serotonin and fills those receptor sites with dopamine, which damages them. So, if you take E and roll a few times a year, it likely won't be a noticeable effect. However, if you roll twice a month or more, you are damaging your brains ability to propperly use the chemical it needs to make you feel happy... so, understand doing E every weekend or for multiple days in a row, is leading you toward a permanant depression and serotonin problem (because you can make it, but now your brain can't utilize it)

That being said, I do love a good roll every now and then. I suggest combining with a healthy amount of 5-htp and if you also have it, try with Ghb, as it does seem to totally negate the hangover the next day, and boost the roll (I suspect it has charactersistics that promote the production of serotonin)

[bandbeyondescription]

if you get confused listen to the music play yeah i dont know much either but inhalants are the worst. :) ;)

[Colimon]

Meth will completely obliterate your brain. Will all those things you're inhaling when you're doing it, it really jsut messes your head up. I think it's the most dangerous and mind changing drug out there.

[Share the Warmth]

are you serious bro...

when i was smoking i was blazing a quarter a day and my lungs were sooooo fucked up. I was coughing up chunks of black, even spots of blood at one point. I was hawkin up phlem all day for years. And Ive never smoked cigarettes. While weed doesnt have as many carcinogens like cigarettes, it contains about 5x the tar that tobacco has. And weed doesnt make you smarter...it does prevent alzheimers but your glamorizing the effect like theres no tomorrow. Preventing alzheimers has nothing to do with gaining intelligence. People who smoke weed chronically have a horrible short term memory and they are slow on the draw mentally, they have no motivation and they eat way too much food. Not like thats a bad thing, i was a pothead for a long time, and its great...i love weed. But saying its HEALTHY is stretchin it man. It might be safe in drug standards, but its definatly not healthy. Eating vegetables is healthy...blazing weed all day is not.

When I say smoking, I don't mean a quarter a day, I mean a few times a week. Anything can be taken to excess, even smoking pot.

But lemme tell you, if you were drinking as much as you were smoking, or taking that much aspirin, or pretty much any other drug, you would have serious permanent ailments because of it. Weed will not mess you up permanently, even if you do smoke every day (granted a lifetime of smoking every day will eventually take its toll on your lungs of course). It can take over your life and screw up your short term memory of course, which is why I use it in moderation.

I mean I smoke ocassionally and I am one of the most observant, quickest thinking people I know. And I have become more observant and perceptive after starting pot than I ever was before. Smoking taught me to really focus and tune in to my surroundings in a way I didn't even know I could do. It's helped me to conquer my fear of heights, gave me a better sense of muscle awareness, and has rekindled my burning desire to learn. Every time I blaze up (once a week usually) I learn something new about myself or my surroundings.

Pot can really help you if you use it correctly.

[Share the Warmth]

are you serious bro...

when i was smoking i was blazing a quarter a day and my lungs were sooooo fucked up. I was coughing up chunks of black, even spots of blood at one point. I was hawkin up phlem all day for years. And Ive never smoked cigarettes. While weed doesnt have as many carcinogens like cigarettes, it contains about 5x the tar that tobacco has. And weed doesnt make you smarter...it does prevent alzheimers but your glamorizing the effect like theres no tomorrow. Preventing alzheimers has nothing to do with gaining intelligence. People who smoke weed chronically have a horrible short term memory and they are slow on the draw mentally, they have no motivation and they eat way too much food. Not like thats a bad thing, i was a pothead for a long time, and its great...i love weed. But saying its HEALTHY is stretchin it man. It might be safe in drug standards, but its definatly not healthy. Eating vegetables is healthy...blazing weed all day is not.

When I say smoking, I don't mean a quarter a day, I mean a few times a week. Anything can be taken to excess, even smoking pot.

But lemme tell you, if you were drinking as much as you were smoking, or taking that much aspirin, or pretty much any other drug, you would have serious permanent ailments because of it. Weed will not mess you up permanently, even if you do smoke every day (granted a lifetime of smoking every day will eventually take its toll on your lungs of course). It can take over your life and screw up your short term memory of course, which is why I use it in moderation.

I mean I smoke ocassionally and I am one of the most observant, quickest thinking people I know. And I have become more observant and perceptive after starting pot than I ever was before. Smoking taught me to really focus and tune in to my surroundings in a way I didn't even know I could do. It's helped me to conquer my fear of heights, gave me a better sense of muscle awareness, and has rekindled my burning desire to learn. Every time I blaze up (once a week usually) I learn something new about myself or my surroundings.

Pot can really help you if you use it correctly.

[StayLoose1011]

Pot can also really hurt you if you use it incorrectly. And guess what, 99.9% of people who smoke pot are going to tell you they use it correctly.

None of us knows shit about this topic. I can be confident of this because no one on Earth knows shit about this topic. It's obvious that some drugs - alcohol, coke, meth, X, LSD - cause serious brain damage when abused. Others - weed, namely - are not so obvious. But, I think for anyone to talk with any sort of authority on this subject only makes one look ridiculous. No one knows the real answer to this. I hate to break it to you, but we don't even know how the brain works.

What am I adding to this thread? I don't know. I guess not much. But yeah, whatever, maybe we will know the real answers some day.

[J.C]

meth puts holes in your brain. So I'd say that one causes the most damage, but then agian there isn't a whole lot of evedence to back it up do to a law the makes it hard to research.

J.C

[Jimmy420]

This one is not on th list but i believe it causes a lot of brain damage.
television

[StayLoose1011]

Excellent point, Jimmy420.

[Share the Warmth]

I agree with you on how little we actually know. That is the one constant truth for me. No one knows, we can only sense, interpret for ourselves, and then act. I do believe in universal truths, and I think we all have access to these truths on some level, regardless of one's level of consciousness. So I think we all decide for ourselves how much truth we want in our lives.

But on the subject of brain damage and drugs, I think we know when we're going too far in that direction by the mean level of appreciation and joy we feel when we're sober. If we're miserable and bored most times when not using a substance, it may be time to get clean.

So I agree, most people who use substances to achieve an altered state swear they're doing so in a safe manner. They say it, but it's how they feel and think about it that matters.

So I think we DO know inside that what we're doing is safe, harmful, or even beneficial, though that knowledge may be contrary to what we tell others.

[Can I Live???]

meth
heroine
crack
inhalants


I dont know why you would want to go near any of those in the first place, but hey its your choice...
To get high ofcourse haha

[StayLoose1011]

I agree with your post, Share the Warmth. It's hard to be honest with ourselves, much less each other, when it comes to the decisions we make about what we ingest (including food, drink, etc.).

[Whiskers123]

How could people choose weed?

[highflyer]

I think some people must be retarded because inhalants are definatley the worst for your brain they get you high because they kill brain cells by cutting oxygen to your head! DONT INHALE SHIT!

[StayLoose1011]

Yeah, I agree. Choosing weed over inhalents is objectively wrong. Damage per use... it's no contest.

[Jemima Truffles]

I don't know about anything scientific, but X has fucked my brain up!

I used to be a highly intelligent functioning woman.......I am still functioning, but I am nowhere near as intelligent as I used to be.....I'm just scattered and all over the place all the time.

Also Meth probably contributed to that in some way. Lots of my friends have drug induced pschyosis (sp?) as a result of excessive X and Meth consumption.

[Whiskers123]

X can be almost anything... its so rare that its pure MDMA. Around half the time there is no MDMA even in it.

So doing X could really mess you up. Most pills are not even 1 drug, so your always mixing drugs and you never really know what with what.

[StayLoose1011]

I responded to this thread before and I can't remember what I said - I think something along the lines of any drug having the potential for serious damage if abused, with the possible exception of weed, and I feel like it still messes you up a little, at least for a while - but upon further reflection, I feel like ecstasy has to take the cake fairly comfortably. I can't think of any other drug (well, maybe LSD) where a weeklong binge could mess you up for life. Alcohol, coke, meth... they will fuck you up, but you've gotta abuse it for a while. I think someone can take X without abusing it and still end up with a lot of fried neurons.

[maddhatter]

^i definatly don't think a weeklong binge of LSD will 'mess you up for life.' it has the potential to change the way you do a lot of things, and usually it's for the better, not for worse. i picked meth but woulda picked inhalants, but thought it just included nitrous oxide. meth is just all around a scary drug. the ingredients are household products that will easily fuck you up on their own, and lots of people can make it in their basement or whatever, i'd just never want to even be around it.

[StayLoose1011]

Well, plenty of people have been messed up for life after taking LSD one time, so, I think you're wrong.

[itsthebig8]

meth: quite shitty for you. Highly addictive, messes up all parts of the body. I find it to be a dirty, nasty, trailer trash drug and would never touch the stuff.

inhalants: everyone has said it, but besides the N2O being not particularly awful for you, the high from household inhalants is directly caused by nerve damage. Fucked up to say the least...

crack/cocaine: cracks more addictive, both are pretty bad for you. Sorry if my science is completely flawed but I'm pretty sure that brain damage isn't the main cause of concern from these drugs. The addiction (although some claim it is only a physiological one) is a large problem, but I truly don't know the specific things it damages. Needless to say, they're not great for you.

LSD: Some say it is completely harmless, some say its seriously damaging to the mind. What I'd say is, saying any street drug is completely harmless is foolish, any mind altering substance when abused can cause damage. Thats not to say that it can be used progressively and responsibly.

THC: A "mostly harmless" drug; it can slow you down, make you less motivated, dumbs you down somewhat when used in absurd quantities. Smoking anything is bad for your lungs, there's no denying it. Its fairly safe though, and the positives massively outweigh the negatives. As with anything, excessive use is dumb.

Alcohol: Its funny how the only legal substance on this list is one of the most dangerous. I guarantee that it kills more people than any drug there is. In moderation, its probably fine. The addictive qualities, and availability make it abused so much that its absolutely one of the most dangerous drugs there is.

X: From what I know, the stuff is fairly safe when taken reasonably. Once in awhile use if perfectly fine, but excessive use is very dangerous. Don't be an idiot.

DXM: Like X (although they are completely different substances), when used in once in a while, it can be safe. People dexin every weekend, or every day for a matter of fact will be affected very negatively. Cut it down to once a month, or less, and it should be okay for you. Moderation is the key word with all drugs.

Opioids: Very little negative effects on your body/brain, but the addiction is what is dangerous. If one gets their fix, their body can function perfectly fine, but withdrawal is very dangerous, and the lifestyle caused by an addiction is not a healthy one.

in terms of medical damage this is my list

inhalants
meth

after that its all down to dosage. Way to much x will be worse for you than coke, but moderate amounts of both, coke will probably be worse.

alcohol
crack
coke
x
dxm
acid
weed
opioids (this is because they do little damage to the brain when the addiction is fulfilled. therefor the absence of this drug is more harmful than the use, and that is not this issue at hand)

[maddhatter]

Well, plenty of people have been messed up for life after taking LSD one time, so, I think you're wrong.i never said that's not true, but the population that would fuck up their life after taking LSD just once is a very very small percent. i'm saying most people have a better outlook on life after taking it than a worse outlook.

[sm0key42o8]

This thread is great! I dont think when it comes to brain damage I wanna take an opinion-think I will stick to facts.

[sm0key42o8]

And by the way NOS by itself does not cause brain damage-its the lack of oxygen from breathing in and out of a ballon

[scratcho]

I didn't see conservatism on the list.That shit's worse than anything listed.It'll rot your brain quicker than anything else.

[heartsnotfarts]

I didn't see conservatism on the list.That shit's worse than anything listed.It'll rot your brain quicker than anything else.
That made my day

[heartsnotfarts]

okay, who were the five people who voted weed?

[Deech]

lol hearts... u gonna go kick there ass or just call em stupid... actually i hear weed doesnt even kill braincells...

is it true that weed doesn't kill braincells it just numbs them for awhile and eventually they all come back and thats also why u have bad memory while your high

[framesh1ft]

I didn't vote because I wanted to vote for inhalants but didn't think it was proper to
generalize, since nitrous can obviously be used safely. Any of these drugs can cause short term brain dysfunction. Inhalants and highly lipophhillic fluids can damage things including your brain almost instantly.

Alcohol is a terrible drug to use to get high and to strongly agonize GABAergic pathways. It is toxic to the nervous system and liver. There are several drugs that are not as easy to obtain (i.e. conditionally illicit) that are much less toxic.

Weed I can say with confidence, does not cause brain damage, since any adverse effects on the mind are probably reversible in almost all users.

Meth, Heroin are highly addictive and strongly induce dependence. Heroin related brain dysfunction is more likely reversible than that of high dose methamphetamine. It may also be the case that amphetamines cause more general damage than the opioids or DXM /PCP/ K. Dissociatives are not as strongly reinforcing as opiates or stimulants. Cocaine perhaps is more cardiotoxic than neurotoxic, or it may be that most users are not on constantly, and thus do not present long-term neuro damage.

Looking at the poll I am somewhat surprised that for once the population more or less is in agreement with my view.

[polymer]

inhalants with paint thinning solvents, and it's not even close. MPP+ does instant damage also...hell, any free radical intermediate will do some damage. alcohol is a GABA modulator, and a fairly polar solvent, which erodes the phospho-layers of cell membranes over time.
and anything that hypermodulates glutamate, will induce excitotoxicity and neuron death.
you might as well have a stroke.

[Jimmy420]

Ecstasy because theres a bunch of different shit in there we don't know about, pure mdma on the other hand, thats a different story, but yea ecstasy in general in my opion

[Whiskers123]

I can't think of any other drug (well, maybe LSD) where a weeklong binge could mess you up for life

LSD wont mess anybody up for life. It can trigger mental illnesses a person already had, however it wont cause mental illness. 1/1000 people (who do LSD) have mental illness triggered from a LSD trip however no study has been able to show that a person who has done LSD is more likely to develop mental illness in there lifetime. I would assume LSD helps as many before they get mental illness than it actually makes it worse but I have no facts to back that up.

On the contrary, people who have smoked marijuana are 8-12% more likely to develop mental illness (probably because some people smoke to much weed and become shut ins and stop socializing with the outside world) and people who have drank Alcohol are over 50% more likely to develop mental illness.

I can say with strong confidence that Alcohol is much worse for your brain than LSD.

[floydianslip6]

the only one up there that HANDS DOWN kills brain cells is nitrous and other inhalants. Meth fucks up your body for sure, and lots of drugs up there can be harmful. But the act of doing an inhalant actually replaces/deprives your brain of oxygen, killing brain cells.

[haggoluc]

alcohol wins by far

[Geneity]

Four people voted.....weed.

lol

[somenerdyfreak]

short-term, inhalants. overall, alcohol.

[rollontheground]

pcp?

[.Xen.]

That sums up the whole thread, right there. I would also like to point out that ecstacy, more often than not, contains either coke or heroin. It's been pointed out that heroin has very few detrimental effects on the brain except through withdrawal symptoms, and coke apparently prevents the reuptake of dopamine. So my question is, what are your thoughts on cocaine and heroin based ecstacy, bill?no it doesnt.. by adding coke and heroin you are adding drugs that are more expensive than the original drug... its bullshit.. that and coke counteracts the effects of ecstasy by temporarlly blocking the recepters that the MDMA acts on... thats why when you do a line of coke when ur rolling balls you start being able to think again! lol. i know this from personal experience... also.

im REALLY sick of that myth... the only things they ever really cut pills with (unless they are retarded) is Meth b/c it prolongs your roll segnifigantly.. anyone that has done molly knows what im talking about.. pure mdma is like a 4 hour high MAYBE! but bombs can last you anywhere from 4 to 8 hours depending on how much meth there is in the bomb. \

i have had pills cut with ketamine... that is prolly where the heroin myth got started...

and about the cocaine thing again, have you ever snorted a bomb and had it go numb? b/c i havent.

[.Xen.]

thats wrong dude...ive eaten hundreds of e pills and i have never ever seen it, all my beans were tested except a very select few...nor has my roll tard friend seen it whos eaten over a thousand beans who owned the testing kit who sold me all the beans ive ever eaten. They never contain coke or heroin...ever, people need to get that straight, it's a MYTH, it makes no sense...

People think that because the roll is dopey it has heroin....nope....pure mdma is dopey as fuck, very mellow, very chill and trippy as hell....the more slow and dopey they are, the more pure they are...doesnt mean they have heroin in them. Do you know how many people would die if heroin were in E pills. Its like speedballing..E is a psychostimulant. Not only is your brain loaded with serotonin, but your heart is racin because it releases dopamine just like coke and just like meth (not to the extent meth does tho)

People think that because a roll is speedy it has coke...wrong...that would defeat the purpose of cutting it, why wouldnt they just add all mdma, coke is worth much more then mdma...plus the amount of coke you could fit in a pill with a good amount of mdma and fillers would get you high for 45 minutes....an hour tops....speedyness in beans is meth, and other cheap stimulants...usually meth because the high lasts for hours as opposed to minutes....

there are NO heroin or coke is street pills...im not saying that there arnt rare cases were it hasnt happened...obviously the myth originated from some fact...but its so rare i garentee no one in here has ever seen it with a tester with there own eyes...if you have then lemmie know...but its been proven time and time again its a myth. Ironically enough people who support the myth have eaten like 10 rolls in their entire life and think they are experts on the subject


On the subject of my roll tard friend whos eaten over a thousand....when you abuse E like that...its BY FAR the most harmful drug....hes fucked for life, i watched his mental state deteriorate and no one could slow down his use no matter who tried to intervene...its was a horrible thing to witness. He can hardly read anymore. At least with meth, your brain recovers from the damage, E fucks you for life.m so glad someone said something.. i was doing bomb every weekend... at least 2 of them... more like 4 and sometimes twice a week for nearly a year and a half... some people might say thats not that much but i forgot how to do algebra... among many other things.. i could LITERALLY tell that my brain was NOT functioning as well... as far as PURE MDMA im sure it is much less damaging but there is something about skittles that fuck your shit up.. I really believe that the hang over is a direct result of damage to your body and brain.. not just with MDMA but also with alcohol and co2...

you guys can say that "ecstasy" isnt damaging all you want but it doesnt change my experiance with it.. i think you all just wanna believe that its not bad for you so you can keep doing it all the time and not feel guilty... here you take 4 skittles and dance ur ass off all night and tell me how you feel the next day..

also, i believe the damage caused by ecstasy has a LOT to do with it heating you up... when your temp is too high for too long it is PROVEN to cause brain damage.. it also causes damage to your organs... even if its only a degree or 2, sustained rise in temp with undoubtedly lead to some tissue damage.

[.Xen.]

the biggest problem with this question is that "brain damage" is not a good measurement for how hard a drug is on you... you should take into accout bodily damage and psychological damage as well... when you account for all of it the truth really comes out as to what is not good for you and what will kill you. lol.
In order from most damaging to least damaging.


alcohol: has way too good a reputation... Its bad for you in every way AND Its legal... yes alcohol every now and then in small amounts is some what beneficial but the line between use and abuse is very fine. the majority of people that drink do it excessively... i know when i drink i usually do it excessively... Alcohol abuse leads to brain damage as in damaged or destroyed cells, and if you are a seriously excessive user you can develop water on the brain... basically all the alcohol pickles your brain, my mother's boss has a son that is 45-ish and has developed the condition... they think hes got maybe 5 more years to live if he keeps drinking. as far as physically there is liver damage... people know all about that, also some kidney damage... and psychologically it makes you stupid, it messes with your response impulses, it turns calm friendly people into raging assholes. and its more addictive than most other drugs as well... all and all it pisses me off that this shit is legal when its one of the most highly toxic of the recrational drugs. I voted alcohol b/c its legal and ruins WAY more lives than heroin, crack, and meth combined.

meth/coke etc.: I am in no way supporting the use of any of these drugs but i do think they have a little more hype than they deserve. Meth ruins families, homes, people, teeth... as far as brain damage goes Fried receptors are never good but no one mentioned that excessive use can lead to a loss of ability to feel physical pleasure and chronic depression. physically it depletes your body of EVERY MAJOR NUTRIENT that it needs... it eats you alive causing muscle problems, skin problems, loss of hair speed bumps, and TMJ... not to mention serious heart issues and overdose leads to heart attacks and strokes. pretty much if your an excessive meth user you probably look like a strung out anorexic... which is pretty much what you are. and psychologically, this is where it gets really bad.. have you ever met a REALLY strung out tweaker? b/c i have known a few.. amphetamine psychosis is not pretty... i had a run in with it briefly about 2 years ago at a party i thru... i was on a 5 day meth binge with a lot of ecstasy in between... by the end of the 5 days i was delirious... i kept hallucinating that there were cops following me on the road and that there were creepy crawlies everywhere... and everytime i tried to eat i got super sick. thats shit is fucked up in everyway i can think of...
Cocaine I think has a really bad rep and it people should lay off it a little. its bad for you in excessive amounts like everything else but if you use it occasionally and maybe mixed with something and only used as an accent drug then its really not all that bad... i would just tell you about coke and crack but i would rather just redirect you to this site... http://www.cocaine.org/
Crack causes some pretty serious psychosis but NOTHING like a really bad tweaker.

inhalants: I dont need to go into detail.. you guys pretty much covered it... dont suffocate ur brain cells.. its just not nice.

Ecstasy: as in skittles... not pure mdma or mda... i dont care what you all say.. it may not put holes in ur brain but it sure does make you fucking stupid. i have mostly shared my views on ecstasy already but i'll run over it again i suppose. as far as brain damage goes i know they havent pin pointed what makes you stupid but something most deffiantly does. fried seritonin receptors obviously, and issues producing seritonin. physically it can really take its tole, i mean im sure most of you have been cracked out before... not to mention TMJ which i developed because of popping skittles. damaged teeth, and organ damage due to your incressed temp, and mild kidney damage. psychologically it obviously can cause depression, and is highly emotionally addictive... i have known many people that years later are still taking ecstasy everyweekend and buying 100 or 200 pills at a time for personal use. i know there cheep but damn. Molly on the other hand has less that a quarter of the negative effects. you dont get cracked out, you dont grind, you dont feel as over heated. i dont know what it is about skittles but there bad news.

heroin: And or opiates and opioids... heroin may not be heavily brain damaging but thats not what makes it bad... the physical effects for example. It Detriorates your body, muscle wasting, vitamin depletion, rotting teeth, brittle bones, and if its taken introveniously it can wear on your circulatory system and lead to heart problems.. its causes kidney and liver damage as well. and psychologically it totally changes who you are... addiction takes hold and that becomes all that matters. heroin may not cause much brain damage but the extent to which it ruins everything else is unforgivable...

dxm: you can all fuck off.. there is no evidence that Dex actually causes you any harm when taken by it self... specially if ur not stupid and you actually extract it like we did... i never had ANY adverse effects from doing dex... the only effects i had was my first taste of chemically induced enlightenment. Dex can be an AMAZING tool if used properly, people just cant seem to get past its stigma of being a drug for 12 yearolds that cant find real drugs... get over it. its just like any other dissociative... you can just buy it at walmart for 2.94$ a dose.

LSD:... I have NO idea why hallucinogens have such a bad rep... is it the government or something? b/c as far as i know LSD has absolutely no measurable adverse physical brain damage. as for physical effects there are none besides an odd body high and slight fatigue the next day and psychologically, Yes... it has been linked the the triggering of latent psychosis, however if it does trigger psychosis you were prolly gonna get it eventually anyway... from my personal experience the use of LSD has done nothing but make Me, my fiance, my sister, my parents, my room mate my best friends I--, c---, a----, f---, j-, r----, j------- (names removed for obvious reasons, i must have been hella stoned when i wrote this) and many more nothing but better people i have never met anyone that went crazy from lsd... for me its turned me into a VERY stable person.. To all of you who have said LSD can fuck you up forever... have you ever even done it? i mean really? b/c i found that all the damage ecstasy did to my brain was more or less repaired by the acid... i can do algebra again and remember words better and generally am just a much better person... and i learn everything much faster. wanna go over some LSD myths? the only one i have found to be true is that LSD damages your chromosomes. apparently in ridiculously high doses it can cause some genetic abnormalities that have lead to mutations in lab animals that were given LSD-50 (not LSD-25) other than that, it doesnt store in your spine from more than 72 hours tops... it doesnt cause your brain to bleed, and if you freak out you will most likely come back from it... the odds of you "getting fucked up" by LSD are about the same as you getting fucked up from vitamin c.. if not less likely than vitamin c.

weed: haha... sometimes when i smoke my lungs swell a little and make it a little harder to breathe... and i cant remember shit.. haha... oh well, stoners rule anyway.

[weedwhacker]

why is marijuana even on this list?

[get_up_stand_up]

That sums up the whole thread, right there. I would also like to point out that ecstacy, more often than not, contains either coke or heroin. It's been pointed out that heroin has very few detrimental effects on the brain except through withdrawal symptoms, and coke apparently prevents the reuptake of dopamine. So my question is, what are your thoughts on cocaine and heroin based ecstacy, bill?With all due respect, heroin/coke based pills is just a myth. Check out pillreports.com or ecstacy data, or erowid.

[krainaoz]

meth meth meth meth the worst shit ever discovered :( it destroys your precios small shiny brain cells and they go grey and say adios 4ever!

[evil i 13]

nitrous, or any inhalant for obvious reasons. It may not be near as addictive as meth, but hit for hit it does FAR more damage, because it's keeping oxygen out of the brain, thus deadening sections of it.

[The Mushroom Man]

Inhalants (not n20) are the only things on this list that will do major shit to your brain the first time you use them, so therefore they should be deemed most hazardous.

[The Backyard Stoner]

True, but you can't get addicted to inhalants but you can become addicted to meth and when you are addicted to it you will smoke every day so in the long run, meth would cause the most brain damage.

[The Mushroom Man]

Backyard, we know at least one person who did inhalants for i dunno about 3 weeks, maybe less, and was already feeling noticeably stupider. I know it's only one case, but inhalants can do more damage in a shorter amount of time than any of the other drugs. Bad shit, cept the N. Oh heavenly, lovely N!

[iamthewalrus22]

Yeah, im my opinion nitrous doesnt do anywhere nearr the damage the other ones do (gasoline, glue, duster) though they all are fun.

[Gooseman]

My best friend and one of the most beautiful girls in the world got hooked on meth, within 6 months i couldn't even recognize her.

Meth, Hands down

[Aldousage]

I think the primary reason meth is doing so well on this list is that "Faces of Meth" video. Most people receive their knowledge (or "knowledge") from television/video, and the style of that video is very effective.

Not that meth shouldn't be near the top of this list. As vague as "inhalants" is, I have to vote for it. Nitrous oxide isn't particularly bad, but breathing in, for example, cyanide gas, can't be good for the old grey matter.

Seriously though, Inhalants, then alcohol, meth and crack.

It's silly that weed and heroin are options. It goes to show the power of suggestion/propaganda. "Heroin" is a dirty word in the public eye, so a poll like this comes along and many people immediately click the naughtiest word.

As for fact vs. opinion, the data available (from sensationalist videos of goofy-looking meth-heads to serious university, government and private studies) is very often conflicting. There is almost always a definite bias held by the data-collectors and/or - more to the point - their employers. Opinion must, necessarily, enter into any given response to this poll.

Peacelove,
Aldousage

[rightside]

mdma can mess up yer mind, cant imagine crack bein too good for it. But there`s not a noticeable crack problem where i come from, so i dunno.
I clicked heroin coz its a filthy thing that destroys people.

LSD like anything cant be good too often but if you take it too often you kind of deserve brain damage. For me LSD and shrooms have been the most positive thing in my life next to my kids. In fact i was bad with bi polar affective disorder till 2006 when I had a year of psychedelic enlightenments. Now I understand God and the self and the universe, and I kid you not I have shrugged bi polar off completly.